Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis

C Coquerelle; G Oldenhove; V Acolty; J Denoeud; G Vansanten; J-M Verdebout; A Mellor; J A Bluestone; M Moser

doi:10.1136/gut.2008.162842

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Inflammatory bowel disease

Anti-CTLA-4 treatment induces IL-10-producing ICOS⁺ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis

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	Abstract	Full	Pdf
Jun 2009	67	0	197
Jul 2009	49	0	67
Aug 2009	23	0	48
Sep 2009	179	77	109
Oct 2009	106	60	77
Nov 2009	44	41	42
Dec 2009	51	19	30
Jan 2010	46	38	31
Feb 2010	33	21	33
Mar 2010	25	37	31
Apr 2010	54	33	26
May 2010	68	26	15
Jun 2010	90	19	24
Jul 2010	42	17	20
Aug 2010	190	27	26
Sep 2010	63	7	13
Oct 2010	33	25	14
Nov 2010	36	19	20
Dec 2010	22	9	10
Jan 2011	30	24	31
Feb 2011	33	7	5
Mar 2011	34	7	9
Apr 2011	40	13	9
May 2011	23	14	12
Jun 2011	31	8	16
Jul 2011	34	5	7
Aug 2011	25	6	9
Sep 2011	31	11	8
Oct 2011	37	10	13
Nov 2011	59	4	17
Dec 2011	40	6	10
Jan 2012	40	1	7
Feb 2012	27	4	17
Mar 2012	53	5	12
Apr 2012	35	6	4
May 2012	33	2	4
Jun 2012	32	4	7
Jul 2012	23	9	6
Aug 2012	24	6	4
Sep 2012	24	1	2
Oct 2012	24	5	2
Nov 2012	41	4	3
Dec 2012	18	7	5
Jan 2013	27	9	8
Feb 2013	30	7	8
Mar 2013	17	4	4
Apr 2013	17	3	4
May 2013	32	2	0
Jun 2013	14	6	2
Jul 2013	16	6	2
Aug 2013	17	4	5
Sep 2013	7	4	5
Oct 2013	19	2	3
Nov 2013	19	1	4
Dec 2013	30	2	3
Jan 2014	20	1	3
Feb 2014	8	1	1
Mar 2014	30	5	7
Apr 2014	13	8	6
May 2014	25	6	7
Jun 2014	18	3	3
Jul 2014	28	3	3
Aug 2014	18	4	5
Sep 2014	26	1	2
Oct 2014	17	2	1
Nov 2014	12	4	1
Dec 2014	24	1	5
Jan 2015	9	1	2
Feb 2015	7	6	8
Mar 2015	16	3	3
Apr 2015	11	2	2
May 2015	10	3	4
Jun 2015	28	3	9
Jul 2015	5	2	4
Aug 2015	18	1	2
Sep 2015	23	2	2
Oct 2015	8	1	3
Nov 2015	11	0	0
Dec 2015	25	4	3
Jan 2016	29	6	8
Feb 2016	13	2	2
Mar 2016	17	1	3
Apr 2016	14	2	0
May 2016	23	1	3
Jun 2016	12	5	1
Jul 2016	35	5	23
Aug 2016	11	6	4
Sep 2016	36	2	1
Oct 2016	27	1	2
Nov 2016	19	0	1
Dec 2016	13	0	0
Jan 2017	22	6	3
Feb 2017	14	2	1
Mar 2017	21	5	5
Apr 2017	24	2	2
May 2017	21	2	3
Jun 2017	39	5	4
Jul 2017	50	3	2
Aug 2017	62	2	4
Sep 2017	80	5	6
Oct 2017	75	4	7
Nov 2017	63	4	6
Dec 2017	45	4	4
Jan 2018	63	2	3
Feb 2018	64	5	8
Mar 2018	73	2	5
Apr 2018	39	3	1
May 2018	29	0	2
Jun 2018	72	6	4
Jul 2018	43	1	1
Aug 2018	52	1	2
Sep 2018	61	2	4
Oct 2018	59	3	7
Nov 2018	48	2	5
Dec 2018	43	4	2
Jan 2019	71	8	5
Feb 2019	51	3	5
Mar 2019	28	3	2
Apr 2019	36	2	3
May 2019	93	7	3
Jun 2019	49	2	2
Jul 2019	39	2	1
Aug 2019	7	1	2
Sep 2019	18	2	0
Oct 2019	17	1	3
Nov 2019	41	3	6
Dec 2019	17	3	2
Jan 2020	20	4	1
Feb 2020	30	2	0
Mar 2020	26	3	2
Apr 2020	28	2	1
May 2020	41	0	0
Jun 2020	112	4	0
Jul 2020	16	2	3
Aug 2020	22	0	1
Sep 2020	46	1	0
Oct 2020	55	3	3
Nov 2020	54	3	3
Dec 2020	28	2	3
Jan 2021	17	2	4
Feb 2021	27	4	0
Mar 2021	25	1	1
Apr 2021	8	2	3
May 2021	12	2	0
Jun 2021	5	5	0
Jul 2021	8	8	1
Aug 2021	3	2	0
Sep 2021	5	4	2
Oct 2021	20	3	0
Nov 2021	29	2	1
Dec 2021	34	4	1
Jan 2022	29	1	0
Feb 2022	14	0	0
Mar 2022	29	1	0
Apr 2022	34	0	1
May 2022	58	4	0
Jun 2022	58	4	1
Jul 2022	22	2	1
Aug 2022	63	3	0
Sep 2022	33	1	0
Oct 2022	139	3	2
Nov 2022	20	4	1
Dec 2022	42	1	0
Jan 2023	35	0	0
Feb 2023	78	1	1
Mar 2023	33	2	0
Apr 2023	16	2	1
May 2023	40	4	0
Jun 2023	4	0	0
Jul 2023	34	1	0
Aug 2023	36	1	0
Sep 2023	29	1	0
Oct 2023	24	1	1
Nov 2023	25	3	2
Dec 2023	48	0	5
Jan 2024	23	0	0
Feb 2024	25	1	0
Mar 2024	18	2	2
Total	6225	1012	1407

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