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Plexitis as Predictive Factor of Early Postoperative Clinical Recurrence in Crohn’s Disease
  1. Harry Sokol (sokol_harry{at}yahoo.fr)
  1. APHP, France
    1. Vanessa Polin
    1. APHP, France
      1. Anne Lavergne-Slove
      1. APHP, France
        1. Yves Panis
        1. APHP, France
          1. Xavier Treton
          1. APHP, France
            1. Xavier Dray
            1. APHP, France
              1. Yoram Bouhnik
              1. APHP, France
                1. Patrice Valleur
                1. APHP, France
                  1. Philippe Marteau
                  1. APHP, France

                    Abstract

                    Background and aims: A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn's disease (CD). Our aim was to assess the predictive value of plexitis for early clinical CD recurrence.

                    Methods: All consecutive patients with ileocolonic or ileal resection for active CD in Lariboisière hospital (Paris) between 1995 and 2006 were included. Clinical, surgical, histological and follow up data were extracted from medical charts. Early clinical recurrence was defined as the reappearance of CD clinical manifestations requiring a specific treatment within two years post surgery. Proximal resection margin was analyzed using haematein eosin saffron (HES) staining and immunochemistry targeting mastocytes (anti-CD117 antibody) and lymphocytes (anti-CD3 antibody). Eosinophils were detected by HES staining. Ten cases of ileocolonic resections for cecal carcinoma served as controls.

                    Results: Data were available from 171 postoperative follow up periods in 164 patients with CD. Early clinical recurrence of CD occurred in 28.1%. In multivariate analysis, factors associated with post operative recurrence were active smoking (HR= 1.94; IC95% [1.06; 3.60] ; p= 0.033), submucosal plexitis with ≥3 mastocytes (HR= 1.87; IC95% [1.00; 3.46] ; p= 0.048) and a disease-free resection margin < 5 cm (HR= 0.52; IC95% [0.27; 1.02] ; p= 0.059).

                    Conclusions: Submucosal plexitis is associated with early clinical recurrence and could be taken into account in studies searching for new treatments strategies in the immediate postoperative period.

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