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Community and personal risk factors for hepatitis C virus infection: a survey of 23 820 residents in Taiwan in 1991–2
  1. Mei-Hsuan Lee1,
  2. Hwai-I Yang1,
  3. Chin-Lan Jen1,
  4. Sheng-Nan Lu2,
  5. Shiou-Hwei Yeh3,
  6. Chun-Jen Liu4,
  7. San-Lin You1,
  8. Chien-An Sun5,
  9. Li-Yu Wang6,
  10. Wei J Chen7,
  11. Chien-Jen Chen1,7,
  12. for the R.E.V.E.A.L.–HCV Study Group*
  1. 1Genomics Research Center, Academia Sinica, Taipei, Taiwan
  2. 2Department of Gastroenterology, Kaohsiung Chang-Gung Memorial Hospital, Kaohsiung, Taiwan
  3. 3Department of Microbiology, National Taiwan University, Taipei, Taiwan
  4. 4Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
  5. 5School of Public Health, Fu-Jen Catholic University, Taipei, Taiwan
  6. 6MacKay Medical College, Taipei, Taiwan
  7. 7Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
  1. Correspondence to Professor Chien-Jen Chen, Genomics Research Center, Academia Sinica, 128 Academia Road Section 2, Nankang, Taipei 11529, Taiwan; cjchen{at}ntu.edu.tw

Abstract

Aim The aim of this study was to explore the community-level risk factors, such as high hepatitis C viruse (HCV)-RNA positive rate and limited medical resources in a township, for HCV infection, one major cause of liver cirrhosis and hepatocellular carcinoma.

Methods This study enrolled 23 820 residents living in 155 villages of seven townships in Taiwan in 1991–2 to explore both individual and community risk factors for HCV infection. Antibodies against HCV (anti-HCV), HCV-RNA and HCV genotype in serum samples were determined by enzyme immunoassay, PCR and melting curve analysis, respectively.

Results The overall anti-HCV seroprevalence was 5.5%, HCV-RNA was detectable in 68.1% of the seropositives of anti-HCV, and genotype 1 was the most prevalent genotype (54.6%). Personal risk factors for the seropositivity of anti-HCV included older age, female gender, low educational level and history of blood transfusion. Based on the multilevel analysis, persons living in villages with high HCV-RNA-positive rates and limited healthcare resources had an increased seroprevalence of anti-HCV after adjustment for individual risk factors. The multivariate-adjusted prevalence OR (95% CI) was 3.49 (1.80 to 6.76) and 8.48 (5.07 to 14.20) for villages with medium and high HCV-RNA positive rate, respectively. The multivariate-adjusted OR (95% CI) was was 1.75 (0.76 to 4.01) and 3.91 (2.25 to 6.80), respectively, for villages with medium and poor healthcare resources.

Conclusions This study suggests that community risk factors contribute significantly to the variation in anti-HCV seroprevalence. It implies both the adequacy of healthcare resources and the treatment of patients positive for HCV-RNA may prevent individual residents from the acquisition of HCV infection from the community.

  • Community survey
  • epidemiology
  • geographical variation
  • HCV RNA
  • hepatitis C
  • multilevel analysis

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Footnotes

  • * Other members of the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer–Hepatitis C Virus (REVEAL–HCV) study are listed in the appendix.

  • Funding This study was supported by research grants from Department of Health, Executive Yuan, Taipei, Taiwan; Bristol-Myers Squibb Co, USA; Academia Sinica, Taipei, Taiwan; and National Health Research Institutes (NHRI-EX98-9806PI), Chunan, Taiwan.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the institutional review board of the College of Public Health at National Taiwan University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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