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  1. Grazia Grazzini1,
  2. Marco Zappa2,
  3. Leonardo Ventura2,
  4. Tiziana Rubeca3,
  5. Stephen P Halloran4
  1. 1Screening Department, Cancer Prevention and Research Institute (ISPO), Florence, Italy
  2. 2Clinical and Descriptive Epidemiology Department, Cancer Prevention and Research Institute (ISPO), Florence, Italy
  3. 3Bio-molecular and Analytical Cytology Laboratory, Cancer Prevention and Research Institute (ISPO), Florence, Italy
  4. 4Bowel Cancer Screening Southern Programme Hub, Postgraduate Medical School, University of Surrey, Guildford, Surrey GU2 7WG, UK
  1. Correspondence to Grazia Grazzini, Department of Screening, ISPO Cancer Prevention and Research Institute, Viale A. Volta 171, 50131 Firenze, Italy; g.grazzini{at}ispo.toscana.it

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It is likely that Dr Guittet and colleagues are correct in their assertion that a reduction in haemoglobin (Hb) concentration due to in vitro degradation will have a disproportionately large effect on the detection of the small bleeds characteristic of intermediate and high-risk adenomas.1 2

As the impetus for worldwide population screening …

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