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Liver stiffness measurement by transient elastography predicts early recovery from acute hepatitis
  1. Vito Di Marco1,
  2. Vincenza Calvaruso1,
  3. Alessandra Iacò1,
  4. Fabrizio Bronte1,
  5. Luciano Biasi2,
  6. Katiela Prestini2,
  7. Paolo Sacchi3,
  8. Giuliana Amaddeo4,
  9. Giovanni Squadrito4,
  10. Raffaele Bruno3,
  11. Massimo Puoti2,
  12. Antonio Craxì1
  1. 1Sezione di Gastroenterologia e Epatologia (Di.Bi.M.I.S.), University of Palermo, Italy
  2. 2Unità complessa di Malattie Infettive, AO Niguarda-Cà Granda, Milano Dipartimento di Malattie Infettive, University of Brescia, Italy
  3. 3Divisione di Malattie Infettive, University di Pavia, Italy
  4. 4Unità di Epatologia Clinica e Biomolecolare, University of Messina, Italy
  1. Correspondence to Vito Di Marco, Dipartimento Biomedico di Medicina Interna e Specialistica, (Di.Bi.M.I.S.), University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy; vito.dimarco{at}tin.it

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We read with interest the lead article by Casterà and Pinzani,1 particularly the comment regarding the role of transient elastography (TE) in the context of acute hepatitis (AH).

The assumption that liver stiffness is determined exclusively by hepatic fibrosis has been challenged by evidence that patients with AH can have high values of liver stiffness measurement (LSM) by TE.2 AH is a suitable model for studying the kinetics of LSM, since inflammation and necrosis increase rapidly and sometimes massively, but may revert with equal speed.

We evaluated 92 consecutive patients (mean age 41.8±16.3 years, 71.7% males) with symptomatic AH to assess how LSM was influenced by aetiology, and whether LSM kinetics correlated with the clinical course of AH. Twelve patients (13%) had …

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