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Risk of all-cause and cardiovascular mortality in patients with chronic liver disease
  1. Giovanni Targher1,
  2. Giacomo Zoppini1,
  3. Christopher P Day2
  1. 1Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy
  2. 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
  1. Correspondence to Dr Giovanni Targher, Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani 1, 37126 Verona, Italy; giovanni.targher{at}univr.it

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We read with interest the article by Stepanova et al in a recent issue of Gut. These authors used death certificate data from the third National Health and Nutrition Examination survey (NHANES-III 1988–1994) in order to assess the impact of metabolic syndrome components on all-cause and cause-specific mortality in patients with chronic liver disease (CLD).1 They concluded that components of the metabolic syndrome are independently associated with overall and liver-related mortality in patients with CLD (principally among those with viral hepatitis C, alcohol-related liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD)).1

Overall, the article is well written and the authors have discussed their results cautiously and in a balanced way, given the well-recognised limitations of using the NHANES-III dataset …

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