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Levofloxacin in first-line eradication regimens for Helicobacter pylori: better test antibiotic susceptibility before treating
  1. Javier Molina-Infante1,
  2. Javier P Gisbert2
  1. 1Department of Gastroenterology, Hospital San Pedro de Alcantara, Caceres, Spain
  2. 2Department of Gastroenterology Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain
  1. Correspondence to Dr Javier Molina-Infante, Department of Gastroenterology, Hospital San Pedro de Alcanatara, Caceres, Avda Pablo Naranjo s/n, Caceres 100003, Spain; xavi_molina{at}hotmail.com

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We sincerely congratulate Romano et al1 for their recent manuscript in Gut showing that levofloxacin-containing sequential therapy can overcome suboptimal cure rates of clarithromycin-containing sequential therapy (≤80% in the intention-to-treat analysis), in a setting with a high clarithromycin resistance rate (20%) but a low levofloxacin resistance rate (3%). Interestingly, we failed to replicate their results in a prior trial with quite a similar design, …

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    Marco Romano Gerardo Nardone