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  1. Daniel E Stange1,2,
  2. Bernhard Radlwimmer1
  1. 1Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany
  2. 2Department of Surgery, University of Heidelberg, Heidelberg, Germany
  1. Correspondence to Dr B Radlwimmer, Division of Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; b.radlwimmer{at}dkfz.de

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We would like to thank Mr Adrian Jubb and his colleagues for sharing their interesting findings.1 In our opinion their data provide additional support for our study2 but fall short of sufficiently addressing the question of the correlation between 11p15.5 DNA copy number gain and ASCL2 expression in liver metastases of colorectal cancer.

Consistent with our findings, Jubb et al did not detect copy number aberrations on chromosome band 11p15.5 in two additional sets of primary colorectal cancers (pCRC). Nevertheless, over-expression of ASCL2 RNA was …

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