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We have reviewed the letter to the editor by Janse et al1 sent in response to Fishbein et al2 in Gut 2008. Our paper reported an association of NOD2 gene polymorphisms with immunologic complications of intestinal transplantation. It was a prospective study in which all sample tissues were uniformly collected, analysed by one method and an extensive clinical outcomes database was prospectively set up to monitor outcomes. It also included significant mechanistic studies demonstrating that the antimicrobial sensing system was …
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