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Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS
  1. Peter Holland-Fischer1,
  2. Henning Grønbæk1,
  3. Thomas Damgaard Sandahl1,
  4. Søren K Moestrup2,3,
  5. Oliviero Riggio4,
  6. Lorenzo Ridola4,
  7. Niels Kristian Aagaard1,
  8. Holger Jon Møller2,
  9. Hendrik Vilstrup1
  1. 1Department of Medicine V (Hepato-Gastroenterology), Aarhus University Hospital, Aarhus, Denmark
  2. 2Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
  3. 3Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
  4. 4Department of Clinical Medicine, University of Rome “La Sapienza”, Rome, Italy
  1. Correspondence to Dr Peter Holland-Fischer, Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark; phf{at}
  • Kupffer cells
  • macrophages
  • portal venous pressure gradient
  • bacterial translocation
  • liver cirrhosis
  • portal hypertension

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  • Funding This study was supported by grants from the Beckett Foundation; Clinical Institute, Aarhus University; the Danish Agency for Science, Technology and Innovation; the Lundbeck Foundation; the NOVO Nordic Foundation; and the A.P. Møller Foundation for the Advancement of Medical Science.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Central Denmark Region Committees on Biomedical Research Ethics and by the ethics committee and research committee of the University of Rome “La Sapienza”.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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