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Cumulative incidence of metachronous colorectal cancer risk for mismatch repair gene mutation carriers is overestimated
  1. Andrew G Renehan
  1. Correspondence to Dr Andrew Renehan, Department of Surgery, University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK; arenehan{at}

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Parry and colleagues1 described the long-term follow-up in a large cohort of mismatch repair (MMR) gene mutation carriers and estimated that among the 332 subjects who had segmental resections, the risk of metachronous colorectal cancer (CRC) was 62% at 30 years after segmental colectomy. In this setting, the appropriate estimate of the probability of failure (ie, metachronous CRC) is cumulative incidence, but as illustrated by Gooley et al,2 the complement of a Kaplan–Meier estimate (1-KM), as used in this paper, is often inappropriately used. In using 1-KM, the failures from a competing event (eg, …

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