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Direction of the brain–gut pathway in functional gastrointestinal disorders
  1. Heather J Whitehouse1,
  2. Alexander C Ford1,2
  1. 1Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK
  2. 2Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
  1. Correspondence to Dr Alexander C Ford, Leeds Gastroenterology Institute, Room 125, 4th Floor, Bexley Wing, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK; alexf12399{at}yahoo.com

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We read the paper by Koloski and colleagues with interest.1 The authors are to be congratulated for conducting a study in >1000 individuals from the general population over such a long period of time. Their finding that the brain–gut axis appears to be bidirectional in functional gastrointestinal (GI) disorders is both important and novel.

In another longitudinal survey with a similar design, but with 10 years of follow-up, poor quality …

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