Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals

Malcolm G Dunlop; Albert Tenesa; Susan M Farrington; Stephane Ballereau; David H Brewster; Thibaud Koessler; Paul Pharoah; Clemens Schafmayer; Jochen Hampe; Henry Völzke; Jenny Chang-Claude; Michael Hoffmeister; Hermann Brenner; Susanna von Holst; Simone Picelli; Annika Lindblom; Mark A Jenkins; John L Hopper; Graham Casey; David Duggan; Polly A Newcomb; Anna Abulí; Xavier Bessa; Clara Ruiz-Ponte; Sergi Castellví-Bel; Iina Niittymäki; Sari Tuupanen; Auli Karhu; Lauri Aaltonen; Brent Zanke; Tom Hudson; Steven Gallinger; Ella Barclay; Lynn Martin; Maggie Gorman; Luis Carvajal-Carmona; Axel Walther; David Kerr; Steven Lubbe; Peter Broderick; Ian Chandler; Alan Pittman; Steven Penegar; Harry Campbell; Ian Tomlinson; Richard S Houlston

doi:10.1136/gutjnl-2011-300537

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Original article

Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals

Authors

Malcolm G Dunlop Colon Cancer Genetics Group, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Albert Tenesa The Roslin Institute, University of Edinburgh, Roslin, UK PubMed articles Google scholar articles
Susan M Farrington Colon Cancer Genetics Group, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Stephane Ballereau Colon Cancer Genetics Group, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
David H Brewster Scottish Cancer Registry, Information Services Division, NHS National Services Scotland, Edinburgh, UK PubMed articles Google scholar articles
Thibaud Koessler Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Paul Pharoah Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Clemens Schafmayer POPGEN Biobank, University Hospital Schleswig-Holstein, Kiel, Germany PubMed articles Google scholar articles
Jochen Hampe Department of General Internal Medicine, University Hospital, Schleswig-Holstein, Kiel, Germany PubMed articles Google scholar articles
Henry Völzke Institut fuer Community Medicine, University Hospital Greifswald, Greifswald, Germany PubMed articles Google scholar articles
Jenny Chang-Claude Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Michael Hoffmeister Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Hermann Brenner Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Susanna von Holst Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Simone Picelli Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Annika Lindblom Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Mark A Jenkins Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Parkville, Victoria, Australia PubMed articles Google scholar articles
John L Hopper Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Parkville, Victoria, Australia PubMed articles Google scholar articles
Graham Casey Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA PubMed articles Google scholar articles
David Duggan Translational Genomics Research Institute (TGen), Phoenix, Arizona, USA PubMed articles Google scholar articles
Polly A Newcomb Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articles Google scholar articles
Anna Abulí Department of Gastroenterology, Hospital del Mar, Institut Municipal d'Investigació Mèdica (IMIM), Pompeu Fabra University, Barcelona, Catalonia, Spain PubMed articles Google scholar articles
Xavier Bessa Department of Gastroenterology, Hospital del Mar, Institut Municipal d'Investigació Mèdica (IMIM), Pompeu Fabra University, Barcelona, Catalonia, Spain PubMed articles Google scholar articles
Clara Ruiz-Ponte Fundación Pública Galega de Medicina Xenómica (FPGMX), CIBERER, Genomic Medicine Group, University of Santiago de Compostela, Santiago de Compostela, Galicia, Spain PubMed articles Google scholar articles
Sergi Castellví-Bel Department of Gastroenterology, Hospital Clínic, CIBERehd, IDIBAPS, University of Barcelona, Catalonia, Spain PubMed articles Google scholar articles
Iina Niittymäki Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland PubMed articles Google scholar articles
Sari Tuupanen Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland PubMed articles Google scholar articles
Auli Karhu Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland PubMed articles Google scholar articles
Lauri Aaltonen Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland PubMed articles Google scholar articles
Brent Zanke Cancer Care Ontario, Toronto, Ontario, Canada PubMed articles Google scholar articles
Tom Hudson Ontario Institute for Cancer Research, Toronto, Ontario, Canada PubMed articles Google scholar articles
Steven Gallinger Samuel Lunenfeld Research Institute, Mount Sinai Hospital and University of Toronto, Toronto Ontario, Canada PubMed articles Google scholar articles
Ella Barclay Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Lynn Martin Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Maggie Gorman Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Luis Carvajal-Carmona Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Axel Walther Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK PubMed articles Google scholar articles
David Kerr Department of Clinical Pharmacology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Steven Lubbe Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK PubMed articles Google scholar articles
Peter Broderick Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK PubMed articles Google scholar articles
Ian Chandler Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK PubMed articles Google scholar articles
Alan Pittman Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK PubMed articles Google scholar articles
Steven Penegar Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK PubMed articles Google scholar articles
Harry Campbell Public Health Sciences, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Ian Tomlinson Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Richard S Houlston Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK PubMed articles Google scholar articles

Correspondence to Professor Malcolm G Dunlop, Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK; malcolm.dunlop{at}igmm.ed.ac.uk

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Citation

Dunlop MG, Tenesa A, Farrington SM, et al

Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals

Gut 2013;62:871-881.

Publication history

Revised March 1, 2012
Accepted March 4, 2012
First published April 5, 2012.

Online issue publication

April 18, 2016

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