Gut doi:10.1136/gutjnl-2012-302311
  • Inflammatory bowel disease
  • Original article

Work disability in inflammatory bowel disease patients 10 years after disease onset: results from the IBSEN Study

  1. IBSEN Group
  1. 1Division of Medicine, Department of Gastroenterology, Oslo University Hospital, Oslo, Norway
  2. 2Department of Internal Medicine, Østfold Hospital, Fredrikstad, Norway
  3. 3Department of Biostatistics, University of Oslo, Oslo, Norway
  4. 4Research and Development Department, Telemark Hospital HF, Skien, Norway
  1. Correspondence to Dr Marte Lie Høivik, Division of Medicine, Department of Gastroenterology, Oslo University Hospital, Aker, P.O Box 4959 Nydalen, 0424 Oslo, Norway; marte.hoivik{at}
  1. Contributors Study concept and design: all authors, Acquisition of data: BM, ICS, TB and MH, Statistical analysis: MLH and MC, Interpretation of data: all authors. Drafting of manuscript: MLH. Critical revision of the manuscript for important intellectual content: all authors. Final approvement of the submitted manuscript: all authors.

  • Revised 16 May 2012
  • Accepted 17 May 2012
  • Published Online First 20 June 2012


Objective To compare the work disability (WD) rate in inflammatory bowel disease (IBD) patients 10 years after disease onset, with the WD rate in the background population,and to assess whether clinical or demographic factors in the early disease course could predict WD after 10 years disease.

Design A large, population-based inception cohort (the Inflammatory Bowel in South Eastern Norway cohort) was prospectively followed up at 1, 5 and 10 years after diagnosis. At the 10-year follow-up data on WD were collected. Data on disability pension (DP) in the background population were retrieved from public databases. We calculated overall and age-standardised relative risks (RR) for DP. Logistic regression analysis was used to examine predictive factors.

Results A total of 518 patients completed the 10-year follow-up (response rate 83.5%). The overall disability rate in the IBD population was 18.8%, and the RR was 1.8 (95% CI 1.4 to 2.3) for ulcerative colitis (UC) and 2.0 (95% CI 1.4 to 2.7) for Crohn's disease (CD). The RR for DP was highest in patients aged below 40 years while patients aged over 60 years had no increased RR. Steroid treatment at the 1-year follow-up predicted WD after 10 years disease in both CD and UC. In UC, increased C-reactive protein (CRP) or erythrocyte sedimentation rate (ESR) at diagnosis, early colectomy, and more than two relapses during the first year of the disease also predicted WD.

Conclusion Ten years after disease onset IBD patients had an increased RR for DP as compared with the background population. The youngest patients had the highest RR. Markers of severe disease course predicted WD.


  • Funding Marte Lie Høivik was supported by South-Eastern Norway Regional Health Authority with a full-time research grant.

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the Regional Ethichs Comitee of the South-Eastern Norway Regional Health Authorities.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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