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Bacterial lipopolyshaccaride inhibits CB2 receptor expression in human monocytic cells
  1. Vedrana Reichenbach1,
  2. Javier Muñoz-Luque1,
  3. Josefa Ros1,
  4. Gregori Casals1,
  5. Miguel Navasa2,3,
  6. Guillermo Fernández-Varo1,3,4,
  7. Manuel Morales-Ruiz1,3,
  8. Wladimiro Jiménez1,3,4
  1. 1Service of Biochemistry and Molecular Genetics, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  2. 2Liver Unit, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  3. 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  4. 4Department of Physiological Sciences I, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  1. Correspondence to Dr Wladimiro Jiménez, Servicio de Bioquímica y Genética Molecular, Hospital Clinic Universitari, Villarroel 170, Barcelona 08036, Spain; wjimenez{at}clinic.ub.es

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We read with interest the recent review by Wiest et al1 on spontaneous bacterial peritonitis (SBP), and would like to point out a new mechanism involved in the pathogenesis of this phenomenon. Cirrhotic patients have altered host-defence response mechanisms and increased susceptibility to bacterial infections, which seem to be related to alterations in the intestinal barrier and/or bacterial translocation from the mucosa to the mesenteric lymph nodes and the intestinal circulation. For this reason, a better understanding on the causes underlying this infection is important for effective future therapies. Both liver cirrhosis and lipopolyshaccaride (LPS)-induced sepsis have been associated with increased activity of endogenous cannabinoids.2 ,3 Our study aims to expand the knowledge on the relationship between Cannabinoid receptor 2 (CB2) receptors and SBP. We analysed the mRNA expression of CB2 in cirrhotic patients with or without SBP, with a mean age of 61±12 years. The aetiology of cirrhosis was alcohol-induced in 5 subjects, 3 with hepatitis B or C, 3 with both …

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