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Bacterial lipopolyshaccaride inhibits CB2 receptor expression in human monocytic cells

https://doi.org/10.1136/gutjnl-2012-303662

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    Footnotes

    • Contributors VR Carried out the main part of the experimental work and designed most of the experiments. JML participated in the experimental procedures with human samples. JR contributed in the cell experimental culture designs and procedures, GC participated in the data analysis. MN kindly provided the human serum samples. GFV aided with the molecular experiments. MMR gave conceptual advice and revised the manuscript. WJ directed the research and wrote the manuscript.

    • Funding This work was supported by grants from Dirección General de Investigación Científica y Técnica (SAF09-08839) and from the Agència de Gestió d'Ajuts Universitaris i de Recerca (SGR 2009/1496). CIBERehd is funded by the Instituto de Salud Carlos III (Spain).

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval The study was performed according to the criteria of the Investigation and Ethics Committee of the Hospital Clínic Universitari.

    • Provenance and peer review Not commissioned; externally peer reviewed.