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Observations suggesting bioactive Fgf15 is not present in mouse blood
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I read with interest the paper by Uriarte et al,1 in which the authors conclude that ‘Fgf15 is a key mediator of the liver growth-promoting effects of bile acids.’
There are reasons to question the conclusions drawn in this paper. Due to space limit I forward three issues.
(1) Fgf15 exerts its effects via FGFR4 as mentioned. The authors have not recognised a report by Yu et al 2 showing that deletion of FGFR4 does not alter the ability of the liver to regenerate after partial hepatectomy.
How can …