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Tracing PAKs from GI inflammation to cancer
  1. Kyle Dammann,
  2. Vineeta Khare,
  3. Christoph Gasche
  1. Department of Medicine III, Division of Gastroenterology and Hepatology and Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Medical University of Vienna, Vienna, Austria
  1. Correspondence to Professor Christoph Gasche, Division of Gastroenterology and Hepatology, Medical University of Vienna, Währinger Gürtel 18-20A-1090, Vienna A-1090, Austria; christoph.gasche{at}meduniwien.ac.at

Abstract

P-21 activated kinases (PAKs) are effectors of Rac1/Cdc42 which coordinate signals from the cell membrane to the nucleus. Activation of PAKs drive important signalling pathways including mitogen activated protein kinase, phospoinositide 3-kinase (PI3K/AKT), NF-κB and Wnt/β-catenin. Intestinal PAK1 expression increases with inflammation and malignant transformation, although the biological relevance of PAKs in the development and progression of GI disease is only incompletely understood. This review highlights the importance of altered PAK activation within GI inflammation, emphasises its effect on oncogenic signalling and discusses PAKs as therapeutic targets of chemoprevention.

  • INFLAMMATORY BOWEL DISEASE
  • COLON CARCINOGENESIS
  • GASTROINTESTINAL CANCER

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