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In 1991 Wotherspoon et al1 showed a close association between Helicobacter pylori infection and gastric mucosa-associated lymphoid tissue (MALT) lymphoma (GML) with the organism present in 92% of cases. Other studies have shown this association to be varying between 42% and 100%. In vitro studies at that time showed that lymphoma cell proliferation was associated with the presence of H. pylori mediated through specific tumour infiltrating T cells in a contact dependant manner. In the light of this finding Wotherspoon et al1 were able to demonstrate that eradication of H. pylori induced lymphoma regression.
In a recent Gut article, Nakamura et al2 demonstrated that H. pylori eradication therapy can result in durable lymphoma regression in the majority of cases. However, absence of H. pylori infection is a known predictive factor for eradication resistance.3
Prevalence of H. pylori has shown signs of decrease especially among Western populations. A decline in the number of GML H. pylori-positive has also been reported.4–7 To address these issues, we performed a retrospective review to analyse the H. pylori infection status …