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Authors’ response: Bile acids are important in the pathophysiology of IBS
  1. Antal Bajor1,
  2. Hans Törnblom1,2,
  3. Mats Rudling3,4,
  4. Kjell-Arne Ung5,
  5. Magnus Simrén1,2
  1. 1Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  2. 2University of Gothenburg Centre for Person-Centred Care (GPCC), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  3. 3Department of Medicine, Metabolism Unit, Center for Endocrinology, Metabolism, and Diabetes, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
  4. 4Molecular Nutrition Unit, Department of Biosciences and Nutrition, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
  5. 5Department of Internal Medicine, Medicine and R&D Unit, Skaraborgs Hospital, Skövde, Sweden
  1. Correspondence to Professor Magnus Simrén, Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden; magnus.simren{at}medicine.gu.se

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We thank Dr Aziz et al1 for expressing their interest in our recent paper, where we demonstrate that bile acids entering the colon may be an important factor for generation of part of the symptoms in patients who fulfil current diagnostic criteria for IBS.2 We agree with their comment that clinicians managing patients with IBS should be aware of the fact that an abnormal 75Se-labelled homocholic acid-taurine (75SeHCAT) test is quite a common finding in patients with non-constipated IBS, and that treating patients with IBS and an abnormal 75SeHCAT test with a bile acid binding agent may improve some of the key symptoms in these patients, especially diarrhoeal …

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