Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts

Weronica E Ek; Anna Reznichenko; Stephan Ripke; Beate Niesler; Marco Zucchelli; Natalia V Rivera; Peter T Schmidt; Nancy L Pedersen; Patrik Magnusson; Nicholas J Talley; Elizabeth G Holliday; Lesley Houghton; Maria Gazouli; George Karamanolis; Gudrun Rappold; Barbara Burwinkel; Harald Surowy; Joseph Rafter; Ghazaleh Assadi; Ling Li; Evangelia Papadaki; Dario Gambaccini; Santino Marchi; Rocchina Colucci; Corrado Blandizzi; Raffaella Barbaro; Pontus Karling; Susanna Walter; Bodil Ohlsson; Hans Tornblom; Francesca Bresso; Anna Andreasson; Aldona Dlugosz; Magnus Simren; Lars Agreus; Greger Lindberg; Guy Boeckxstaens; Massimo Bellini; Vincenzo Stanghellini; Giovanni Barbara; Mark J Daly; Michael Camilleri; Mira M Wouters; Mauro D'Amato

doi:10.1136/gutjnl-2014-307997

Article info

Neurogastroenterology

Original article

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts

Authors

Weronica E Ek Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Anna Reznichenko Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Stephan Ripke Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Beate Niesler Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Marco Zucchelli Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Natalia V Rivera Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Peter T Schmidt Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Nancy L Pedersen Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Patrik Magnusson Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Nicholas J Talley Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia PubMed articles Google scholar articles
Elizabeth G Holliday Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia PubMed articles Google scholar articles
Lesley Houghton Faculty of Medical and Human Sciences, Institute of Inflammation and Repair, University of Manchester, Manchester, UK Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA PubMed articles Google scholar articles
Maria Gazouli Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece PubMed articles Google scholar articles
George Karamanolis Academic Department of Gastroenterology, School of Medicine, University of Athens, Athens, Greece PubMed articles Google scholar articles
Gudrun Rappold Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Barbara Burwinkel Molecular Epidemiology Group, German Cancer Research Centre (DKFZ) Heidelberg, Heidelberg, Germany Division of Molecular Biology of Breast Cancer, Department of Gynaecology and Obstetrics, University Women's Clinic, University Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Harald Surowy Molecular Epidemiology Group, German Cancer Research Centre (DKFZ) Heidelberg, Heidelberg, Germany Division of Molecular Biology of Breast Cancer, Department of Gynaecology and Obstetrics, University Women's Clinic, University Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Joseph Rafter Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Ghazaleh Assadi Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Ling Li Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Evangelia Papadaki Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Dario Gambaccini Gastroenterology Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Santino Marchi Gastroenterology Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Rocchina Colucci Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Corrado Blandizzi Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Raffaella Barbaro Department of Medical and Surgical Sciences, University of Bologna, St. Orsola—Malpighi Hospital, Bologna, Italy PubMed articles Google scholar articles
Pontus Karling Department of Medicine, Umeå, University, Umeå, Sweden PubMed articles Google scholar articles
Susanna Walter Division of Gastroenterology, Institution of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden PubMed articles Google scholar articles
Bodil Ohlsson Department of Clinical Sciences, Skånes University Hospital, Malmoe, Sweden PubMed articles Google scholar articles
Hans Tornblom Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden PubMed articles Google scholar articles
Francesca Bresso Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Anna Andreasson Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Stress Research Institute, Stockholm University, Stockholm, Sweden PubMed articles Google scholar articles
Aldona Dlugosz Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Magnus Simren Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden PubMed articles Google scholar articles
Lars Agreus Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Greger Lindberg Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Guy Boeckxstaens Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium PubMed articles Google scholar articles
Massimo Bellini Gastroenterology Unit, Department of Gastroenterology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Vincenzo Stanghellini Department of Medical and Surgical Sciences, University of Bologna, St. Orsola—Malpighi Hospital, Bologna, Italy PubMed articles Google scholar articles
Giovanni Barbara Department of Medical and Surgical Sciences, University of Bologna, St. Orsola—Malpighi Hospital, Bologna, Italy PubMed articles Google scholar articles
Mark J Daly Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Michael Camilleri Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Mira M Wouters Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium PubMed articles Google scholar articles
Mauro D'Amato Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles

Correspondence to Dr Mauro D'Amato, Department of Biosciences and Nutrition, Karolinska Institutet, Halsovag 7-9, Stockholm SE-14183, Sweden; mauro.damato{at}ki.se

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Citation

Ek WE, Reznichenko A, Ripke S, et al

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts

Gut 2015;64:1774-1782.

Publication history

Received July 8, 2014
Revised August 20, 2014
Accepted August 21, 2014
First published September 23, 2014.

Online issue publication

October 26, 2017

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