Article Text

other Versions

PDF
Predicting future disease course in Crohn’s disease by colonoscopy or magnetic resonance: which is the crystal ball?
  1. Silvio Danese1,
  2. Laurent Peyrin-Biroulet2,
  3. Gionata Fiorino1
  1. 1Department of Gastroenterology, IBD Center, Humanitas Research Hospital, Rozzano, Milan, Italy
  2. 2Inserm, U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy, Université de Lorraine, Vandoeuvre-lès-Nancy, France
  1. Correspondence to Dr Silvio Danese, IBD Center, Department of Gastroenterology, Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy; sdanese{at}hotmail.com

Statistics from Altmetric.com

Crohn's disease (CD) is a chronic and progressive condition leading to cumulative bowel damage overtime, mainly related to stricturing or penetrating lesions. About half of patients with CD require surgical intestinal resection 10 years after diagnosis.1 Importantly, the development of disease complications (stricture, fistula and/or abscess) is known to be the main indication for surgery in these patients.1 The identification of factors associated with a higher need for surgery for CD is a prerequisite to the development of therapeutic strategies potentially altering disease course, with the final aim of preventing undertreatment and avoiding overtreatment with biologics.

Clinical risk factors are insufficient to predict disease course,2 and there is a well-known disconnect between clinical symptoms and endoscopic disease activity.3 Hence, we need to look beyond clinical symptoms. Accumulating evidence indicates that mucosal healing may change the natural course of the disease by decreasing the need for surgery and reducing hospitalisation rates in CD.4 However, no controlled trials addressed this question and only indirect evidence is available. Furthermore, CD is a transmural disease, and endoscopy, which is still the gold standard for assessing disease activity in CD, cannot detect the presence of bowel damage. Over the last decade, cross-sectional imaging techniques, such as MRI, CT and ultrasound, have …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles