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Genetic variants of lipase activity in chronic pancreatitis
  1. Holger Kirsten1,2,
  2. Markus Scholz1,2,
  3. Peter Kovacs3,
  4. Harald Grallert4,5,6,
  5. Annette Peters5,6,7,
  6. Konstantin Strauch8,9,
  7. Josef Frank10,
  8. Marcella Rietschel10,
  9. Markus M Nöthen11,12,
  10. Heiko Witt13,
  11. Jonas Rosendahl14
  1. 1Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
  2. 2LIFE—Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
  3. 3Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany
  4. 4Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany
  5. 5Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany
  6. 6German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
  7. 7DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
  8. 8Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany
  9. 9Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
  10. 10Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany
  11. 11Department of Genomics, Life & Brain Centre, University of Bonn, Bonn, Germany
  12. 12Institute of Human Genetics, University of Bonn, Bonn, Germany
  13. 13Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Zentralinstitut für Ernährungs- und Lebensmittelforschung (ZIEL) & Paediatric Nutritional Medicine, Technische Universität München (TUM), Munich, Germany
  14. 14Division of Gastroenterology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany
  1. Correspondence to Dr Jonas Rosendahl, Division of Gastroenterology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Liebigstraße 20, Leipzig 04103, Germany; jonas.rosendahl{at}medizin.uni-leipzig.de

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We read with great interest the article by Weiss et al1 reporting genetic associations of rs632111 (fucosyltransferase 2; FUT2), rs8176693 (ABO) and rs889512 (chymotrypsinogen B2; CTRB2) with lipase levels. Weiss et al also claimed that the variants at the FUT2 and ABO loci were associated with chronic pancreatitis (CP). No association with CP was observed for the CTRB2 locus. Elevated lipase levels are a diagnostic criterion for acute pancreatitis and might mirror subclinical pancreatic injury in patients without severe complaints. Hence, variants associated with elevated serum lipase levels might also be associated with CP risk. In a recent genome-wide association study, genetic variants of CP risk were identified in PRSS1 and CLDN2-MORC4.2 A large European replication study refined these associations to alcohol-related CP.3 However, no associations were revealed at FUT2 and ABO in the former genome-wide association study.2

Given the relatively moderate association of genetic variants with CP in the paper by Weiss et al, we analysed the above-mentioned FUT2 and ABO single nucleotide polymorphism (SNPs) regarding association with CP in a German cohort of 1458 cases (non-alcohol-related CP n=584; …

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