Article Text

other Versions

PDF
Letter
Comparison of the in vitro susceptibility of rifaximin versus norfloxacin against multidrug resistant bacteria in a hospital setting. A proof-of-concept study for use in advanced cirrhosis
  1. J M Ramos1,2,
  2. I Vidal3,
  3. P Bellot4,5,
  4. I Gómez-Hurtado5,
  5. P Zapater5,6,
  6. J Such5,7
  1. 1Department of Clinical Medicine, Miguel Hernández University, Elche, Alicante, Spain
  2. 2Departments of Internal Medicine, Hospital General Universitario, Alicante, Spain
  3. 3Departments of Microbiology, Hospital General Universitario, Alicante, Spain
  4. 4Liver Unit, Hospital General Universitario, Alicante, Spain
  5. 5CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
  6. 6Department of Clinical Pharmacology, Hospital General Universitario, Alicante, Spain
  7. 7Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE
  1. Correspondence to J M Ramos, Department of Internal Medicine, Hospital General Universitario, Alicante, Pintor Alonso, 12, Alicante 03010, Spain; jramosrincon{at}yahoo.es

Statistics from Altmetric.com

We read with interest the recent letter to the editor from Waidmann et al1 investigating the effect of multidrug resistant (MDR) bacteria intestinal colonisation on the prognosis of patients with cirrhosis. The authors concluded that infections due to MDR bacteria and asymptomatic intestinal colonisation with MDR bacteria are a risk factor for mortality in cirrhosis. That information expands the relevance of preventing and treating infections due to MDR bacteria in patients with cirrhosis.

Infections due to MDR bacteria are mostly nosocomial in origin and represent an increasing threat in decompensated cirrhosis, due to the high requirement of changing antibiotics and its associated mortality.2 According to the actual pathogenic hypothesis of spontaneous infections in cirrhosis, a nosocomial spontaneous infection due to MDR bacteria should be preceded by its colonisation of the intestinal lumen and …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.