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We read with great interest the comprehensive study by Mocellin and colleagues1 who developed a quantitative summary of candidate genetic variants for gastric cancer susceptibility. Based on different tumour sites, the authors conducted a subgroup analysis for cardia cancer (CC) and non-cardia cancer (NCC). It is well established that CC has distinctive characteristics compared with NCC, but shares some common risk factors and pathogenesis with oesophageal cancer (OSC). In addition, there are some different genetic factors such as genetic variants between patients with CC and NCC. There is an argument that CC, located at oesophago-gastric junction, belongs to oesophageal more than gastric cancer.
According to the results of subgroup analysis, Mocellin and colleagues1 found several variants showing different results with CC and NCC risk. However, only PLCE1 rs2274223 was reported to be significantly associated with CC but not NCC risk with high credibility …