Article Text

other Versions

PDF
House dust mite: a new player in intestinal inflammation?
  1. Manon E Wildenberg,
  2. Gijs R van den Brink
  1. Department of Gastroenterology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
  1. Correspondence to Dr Manon E Wildenberg, Department of Gastroenterology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69-71, Amsterdam 1105 BK, The Netherlands; m.e.wildenberg{at}amc.nl

Statistics from Altmetric.com

Over the past decades, incidence rates of immune-mediated inflammatory diseases including asthma and IBDs have been rising steadily in both Western and low/middle-income countries.1 The cause of this increase has been a topic of intense investigation, and a variety of factors such as diet, hygiene and pollution have been implicated. One of the most clear correlations between disease and environment is that between exposure to house dust mite (HDM) and asthma exacerbations.2 HDM contains several antigens, including Der p1, a cysteine protease that damages the airway epithelium thus allowing antigens to pass into the pulmonary tissue.3 In atopic individuals, this results in a potent IgE-mediated specific anti-Der …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles