Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

Tobias Schwerd; Sumeet Pandey; Huei-Ting Yang; Katrin Bagola; Elisabeth Jameson; Jonathan Jung; Robin H Lachmann; Neil Shah; Smita Y Patel; Claire Booth; Heiko Runz; Gesche Düker; Ruth Bettels; Marianne Rohrbach; Subra Kugathasan; Helen Chapel; Satish Keshav; Abdul Elkadri; Nick Platt; Alexio M Muise; Sibylle Koletzko; Ramnik J Xavier; Thorsten Marquardt; Fiona Powrie; James E Wraith; Mads Gyrd-Hansen; Frances M Platt; Holm H Uhlig

doi:10.1136/gutjnl-2015-310382

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Inflammatory bowel disease

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Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

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Tobias Schwerd Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Sumeet Pandey Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Huei-Ting Yang Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Katrin Bagola Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Elisabeth Jameson Willink Biochemical Genetics Unit, Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Manchester, UK PubMed articles Google scholar articles
Jonathan Jung Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Robin H Lachmann National Hospital for Neurology and Neurosurgery, London, UK PubMed articles Google scholar articles
Neil Shah Great Ormond Street Hospital, London, UK PubMed articles Google scholar articles
Smita Y Patel NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Claire Booth Department of Clinical Immunology, Great Ormond Street Hospital, London, UK PubMed articles Google scholar articles
Heiko Runz University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Gesche Düker University Children's Hospital Bonn, Bonn, Germany PubMed articles Google scholar articles
Ruth Bettels Children's Hospital Münster, Münster, Germany PubMed articles Google scholar articles
Marianne Rohrbach Children's Research Centre Zurich, University Children's Hospital, Zurich, Switzerland PubMed articles Google scholar articles
Subra Kugathasan Division of Pediatric Gastroenterology, Emory University School of Medicine, Atlanta, Georgia, USA PubMed articles Google scholar articles
Helen Chapel NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Satish Keshav Translational Gastroenterology Unit, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Abdul Elkadri SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Nick Platt Department of Pharmacology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Alexio M Muise SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
Sibylle Koletzko Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany PubMed articles Google scholar articles
Ramnik J Xavier Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Thorsten Marquardt Children's Hospital Münster, Münster, Germany PubMed articles Google scholar articles
Fiona Powrie Translational Gastroenterology Unit, University of Oxford, Oxford, UK Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
James E Wraith Willink Biochemical Genetics Unit, Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Manchester, UK PubMed articles Google scholar articles
Mads Gyrd-Hansen Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Frances M Platt Department of Pharmacology, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Holm H Uhlig Translational Gastroenterology Unit, University of Oxford, Oxford, UK Department of Pediatrics, University of Oxford, Oxford, UK PubMed articles Google scholar articles

Correspondence to Dr Holm H Uhlig, Translational Gastroenterology Unit, Experimental Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK; holm.uhlig{at}ndm.ox.ac.uk

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Citation

Schwerd T, Pandey S, Yang H, et al

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

Gut 2017;66:1060-1073.

Publication history

Received July 16, 2015
Revised January 6, 2016
Accepted January 14, 2016
First published March 7, 2016.

Online issue publication

June 12, 2017

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