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  • Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

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Pancreas
Original article
Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

Authors

  • Yaqing Zhang Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Ashley Velez-Delgado Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Esha Mathew Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Dongjun Li Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Flor M Mendez Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Kevin Flannagan Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Andrew D Rhim Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Diane M Simeone Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  • Gregory L Beatty Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, Philadelphia, Pennsylvania, USA Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Marina Pasca di Magliano Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Marina Pasca di Magliano, PhD, Department of Surgery and Department of Cell and Developmental Biology, University of Michigan Medical School, 1500 E Medical Center Drive, Cancer Center 4304, Ann Arbor, MI 48109-5936, USA; marinapa{at}umich.edu
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Citation

Zhang Y, Velez-Delgado A, Mathew E, et al
Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer
Gut 2017;66:124-136.

Publication history

  • Received April 15, 2016
  • Revised May 26, 2016
  • Accepted June 10, 2016
  • First published July 8, 2016.
Online issue publication 
July 07, 2018

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/