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Original article
An evidence-based treatment algorithm for colorectal polyp cancers: results from the Scottish Screen-detected Polyp Cancer Study (SSPoCS)
  1. CH Richards1,
  2. NT Ventham2,
  3. D Mansouri3,
  4. M Wilson4,
  5. G Ramsay1,
  6. CD Mackay1,
  7. CN Parnaby5,
  8. D Smith1,
  9. J On1,
  10. D Speake6,
  11. G McFarlane7,
  12. YN Neo4,
  13. E Aitken3,
  14. C Forrest3,
  15. K Knight3,
  16. A McKay3,
  17. H Nair2,
  18. C Mulholland2,
  19. JH Robertson8,
  20. FA Carey9,
  21. RJC Steele10
  22. on behalf of The Scottish Surgical Research Group
  1. 1General Surgery Training Programme, North of Scotland Deanery, UK
  2. 2General Surgery Training Programme, South-East of Scotland Deanery, UK
  3. 3General Surgery Training Programme, West of Scotland Deanery, UK
  4. 4General Surgery Training Programme, East of Scotland Deanery, UK
  5. 5Department of Surgery, Aberdeen Royal Infirmary, Aberdeen, UK
  6. 6Department of Colorectal Surgery, Western General Hospital, Edinburgh, UK
  7. 7Department of Surgery, Gilbert Bain Hospital, Lerwick, UK
  8. 8Department of Surgery, Victoria Hospital, Kirkcaldy, UK
  9. 9University Department of Pathology, Ninewells Hospital, Dundee, UK
  10. 10University Department of Surgery, Ninewells Hospital, Dundee, UK
  1. Correspondence to CH Richards, University Department of Surgery, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN, UK; colinhrichards{at}hotmail.com

Abstract

Objectives Colorectal polyp cancers present clinicians with a treatment dilemma. Decisions regarding whether to offer segmental resection or endoscopic surveillance are often taken without reference to good quality evidence. The aim of this study was to develop a treatment algorithm for patients with screen-detected polyp cancers.

Design This national cohort study included all patients with a polyp cancer identified through the Scottish Bowel Screening Programme between 2000 and 2012. Multivariate regression analysis was used to assess the impact of clinical, endoscopic and pathological variables on the rate of adverse events (residual tumour in patients undergoing segmental resection or cancer-related death or disease recurrence in any patient). These data were used to develop a clinically relevant treatment algorithm.

Results 485 patients with polyp cancers were included. 186/485 (38%) underwent segmental resection and residual tumour was identified in 41/186 (22%). The only factor associated with an increased risk of residual tumour in the bowel wall was incomplete excision of the original polyp (OR 5.61, p=0.001), while only lymphovascular invasion was associated with an increased risk of lymph node metastases (OR 5.95, p=0.002). When patients undergoing segmental resection or endoscopic surveillance were considered together, the risk of adverse events was significantly higher in patients with incomplete excision (OR 10.23, p<0.001) or lymphovascular invasion (OR 2.65, p=0.023).

Conclusion A policy of surveillance is adequate for the majority of patients with screen-detected colorectal polyp cancers. Consideration of segmental resection should be reserved for those with incomplete excision or evidence of lymphovascular invasion.

  • POLYP
  • CANCER
  • COLORECTAL CANCER SCREENING
  • SURVEILLANCE

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Footnotes

  • Collaborators The Scottish Surgical Research Group.

  • Contributors RJCS and FAC proposed the project to the Scottish Surgical Research Group, a trainee-led research collaborative. GR was responsible for the relevant ethical approvals and liased with the Scottish Bowel Screening Programme. CHR coordinated data collection in the North of Scotland Deanery, NTV in the South West of Scotland, DM in the West of Scotland and MW in the East of Scotland. All other authors extracted, collected and assimilated data from their relevant geographical area. These data were analysed by CHR and NTV. CHR wrote the manuscript, which was revised and edited by RJCS, FAC, NTV, DM, MW, GR and CDM. All other authors provided advice, intellectual input and approved the final manuscript.

  • Competing interests None.

  • Ethics approval National Caldicott Guardian for Scotland.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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