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Blood group B is associated with azathioprine-induced acute pancreatitis in patients with IBD
  1. Niels Teich1,
  2. Bernd Bokemeyer2,
  3. Wolfgang Mohl3,
  4. Jens Walldorf4,
  5. Tony Bruns5,
  6. Carsten Schmidt5,
  7. Andreas Stallmach5
  8. on behalf of the German IBD Study Group
  1. 1Internistische Gemeinschaftspraxis, Leipzig, Germany
  2. 2Gastroenterologische Gemeinschaftspraxis, Minden, Germany
  3. 3Gemeinschaftspraxis—Endoskopiezentrum, Saarbrücken, Germany
  4. 4Universitätsklinikum Halle, Universitätsklinik und Poliklinik für Innere Medizin I, Halle, Germany
  5. 5Universitätsklinikum Jena, Klinik für Innere Medizin IV, Jena, Germany
  1. Correspondence to Dr Niels Teich, Internistische Gemeinschaftspraxis für Verdauungs-und Stoffwechselkrankheiten, Nordstr. 21, Leipzig D-04105, Germany; teich{at}igvs.de

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In a recently published study of asymptomatic volunteers from a population-based study (n=3966) and healthy blood donors (n=1444), genetic polymorphisms that determine the fucosyltransferase-2 non-secretor status and the ABO blood type B were significantly associated with increased serum lipase activities.1 Furthermore, the study was the first one to identify the inherited Lewis and ABO blood group systems as relevant factors for the development of pancreatitis, that is, blood group B carriers displayed 1.69-fold odds of developing chronic pancreatitis.1 Little is known about the pathogenesis of azathioprine-induced acute pancreatitis (AIAP) in patients with inflammatory bowel diseases (IBDs). In a first prospective multicentre study on the incidence of AIAP in patients with thiopurine-naive IBD, we were able to identify smoking at the time of azathioprine induction as the strongest and dose-dependent risk factor.2 Stimulated by the findings of Weiss et al,1 we have this time investigated whether patients with IBD who …

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