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In a recently published study of asymptomatic volunteers from a population-based study (n=3966) and healthy blood donors (n=1444), genetic polymorphisms that determine the fucosyltransferase-2 non-secretor status and the ABO blood type B were significantly associated with increased serum lipase activities.1 Furthermore, the study was the first one to identify the inherited Lewis and ABO blood group systems as relevant factors for the development of pancreatitis, that is, blood group B carriers displayed 1.69-fold odds of developing chronic pancreatitis.1 Little is known about the pathogenesis of azathioprine-induced acute pancreatitis (AIAP) in patients with inflammatory bowel diseases (IBDs). In a first prospective multicentre study on the incidence of AIAP in patients with thiopurine-naive IBD, we were able to identify smoking at the time of azathioprine induction as the strongest and dose-dependent risk factor.2 Stimulated by the findings of Weiss et al,1 we have this time investigated whether patients with IBD who …
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