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Hepatology
Original article
ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis

Authors

  • Abdo Mahli Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Michael Saugspier Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany PubMed articlesGoogle scholar articles
  • Andreas Koch Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Judith Sommer Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Peter Dietrich Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Seren Lee Biobank o.b. HTCR, Department of General Visceral- and Transplantation Surgery, Ludwig-Maximilians-University Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Reinhard Thasler Biobank o.b. HTCR, Department of General Visceral- and Transplantation Surgery, Ludwig-Maximilians-University Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Jan Schulze-Luehrmann Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Anja Luehrmann Mikrobiologisches Institut – Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Wolfgang Erwin Thasler Biobank o.b. HTCR, Department of General Visceral- and Transplantation Surgery, Ludwig-Maximilians-University Munich, Munich, Germany PubMed articlesGoogle scholar articles
  • Martina Müller Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany PubMed articlesGoogle scholar articles
  • Anja Bosserhoff Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany Comprehensive Cancer Center Erlangen, CCC Erlangen-EMN, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Claus Hellerbrand Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany Institute of Biochemistry (Emil-Fischer Zentrum), Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Claus Hellerbrand, Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen D-91054, Germany; claus.hellerbrand{at}fau.de
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Citation

Mahli A, Saugspier M, Koch A, et al
ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis
Gut 2018;67:746-756.

Publication history

  • Received June 22, 2016
  • Revised December 7, 2016
  • Accepted December 8, 2016
  • First published January 4, 2017.
Online issue publication 
July 25, 2018

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