BMP-9 interferes with liver regeneration and promotes liver fibrosis

Katja Breitkopf-Heinlein; Christoph Meyer; Courtney König; Haristi Gaitantzi; Annalisa Addante; Maria Thomas; Eliza Wiercinska; Chen Cai; Qi Li; Fengqi Wan; Claus Hellerbrand; Nektarios A Valous; Maximilian Hahnel; Christian Ehlting; Johannes G Bode; Stephanie Müller-Bohl; Ursula Klingmüller; Jutta Altenöder; Iryna Ilkavets; Marie-José Goumans; Lukas J A C Hawinkels; Se-Jin Lee; Matthias Wieland; Carolin Mogler; Matthias P Ebert; Blanca Herrera; Hellmut Augustin; Aránzazu Sánchez; Steven Dooley; Peter ten Dijke

doi:10.1136/gutjnl-2016-313314

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Hepatology

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BMP-9 interferes with liver regeneration and promotes liver fibrosis

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Katja Breitkopf-Heinlein Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Christoph Meyer Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Courtney König Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany PubMed articles Google scholar articles
Haristi Gaitantzi Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Annalisa Addante Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University of Madrid, San Carlos Clinical Hospital Health Research Institute (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Maria Thomas Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany PubMed articles Google scholar articles
Eliza Wiercinska German Red Cross Blood Service Baden-Württemberg-Hessen and Institute for Transfusion Medicine and Immunohaematology, Goethe University, Frankfurt, Germany PubMed articles Google scholar articles
Chen Cai Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Qi Li Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany Department of Gastroenterology and Hepatology, Beijing You'an Hospital, Affiliated with Capital Medical University, Beijing, China PubMed articles Google scholar articles
Fengqi Wan Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Claus Hellerbrand Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany PubMed articles Google scholar articles
Nektarios A Valous Applied Tumor Immunity Clinical Cooperation Unit, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany PubMed articles Google scholar articles
Maximilian Hahnel University Hospital of the Heinrich-Heine University, Duesseldorf, Germany PubMed articles Google scholar articles
Christian Ehlting University Hospital of the Heinrich-Heine University, Duesseldorf, Germany PubMed articles Google scholar articles
Johannes G Bode University Hospital of the Heinrich-Heine University, Duesseldorf, Germany PubMed articles Google scholar articles
Stephanie Müller-Bohl Division Systems Biology of Signal Transduction, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Ursula Klingmüller Division Systems Biology of Signal Transduction, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Jutta Altenöder Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Iryna Ilkavets Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Marie-José Goumans Department of Molecular Cell Biology and Centre for Cancer Genomics, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Lukas J A C Hawinkels Department of Molecular Cell Biology and Centre for Cancer Genomics, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Se-Jin Lee Johns Hopkins University School of Medicine, Molecular Biology and Genetics, Baltimore, USA PubMed articles Google scholar articles
Matthias Wieland Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany PubMed articles Google scholar articles
Carolin Mogler Institute of Pathology, Technical University of Munich, München, Germany PubMed articles Google scholar articles
Matthias P Ebert Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Blanca Herrera Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University of Madrid, San Carlos Clinical Hospital Health Research Institute (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Hellmut Augustin Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany German Cancer Consortium, Heidelberg, Germany PubMed articles Google scholar articles
Aránzazu Sánchez Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University of Madrid, San Carlos Clinical Hospital Health Research Institute (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Steven Dooley Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany PubMed articles Google scholar articles
Peter ten Dijke Department of Molecular Cell Biology and Centre for Cancer Genomics, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles

Correspondence to Dr Katja Breitkopf-Heinlein, Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim D-68167, Germany; katja.breitkopf{at}medma.uni-heidelberg.de

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Citation

Breitkopf-Heinlein K, Meyer C, König C, et al

BMP-9 interferes with liver regeneration and promotes liver fibrosis

Gut 2017;66:939-954.

Publication history

Received October 28, 2016
Revised February 22, 2017
Accepted March 2, 2017
First published March 23, 2017.

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October 26, 2017

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