Article Text

other Versions

PDF
Feeding the microbiota: transducer of nutrient signals for the host
  1. Fergus Shanahan,
  2. Douwe van Sinderen,
  3. Paul W O’Toole,
  4. Catherine Stanton
  1. Departments of Medicine and Microbiology, APC Microbiome Institute and Schools of Medicine and Microbiology, University College Cork, National University of Ireland and Teagasc, Cork, Ireland
  1. Correspondence to Professor Fergus Shanahan, APC Microbiome Institute and Schools of Medicine and Microbiology, University College Cork, National University of Ireland and Teagasc, Cork, Ireland; f.shanahan{at}ucc.ie

Abstract

Advances in microbiome science cast light on traditional concepts on nutritional science, and are poised for clinical translation. Epidemiologic observations which linked lifestyle factors to risk of disease are being re-interpreted with mechanistic insight based on improved understanding of the microbiota. Examples include the role of dietary fibre in disease prevention, the deleterious effects of highly restricted diets, and the contribution of the microbiota to over- and undernutrition. While the microbiota transduces nutrient signals for the host, food and habitual diet shape the composition of the gut microbiota at every stage of life. The composition and diversity of food intake determines which microbes will colonise, flourish, persist, or become extinct. Disruption of the developing microbiota in infancy contributes to the risk of immune and metabolic disease in later life, whereas loss of microbes in the elderly due to monotonous diets has been linked with unhealthy ageing and frailty. This should influence modern dietary advice regarding prevention and management of chronic non-communicable inflammatory and metabolic disorders, and will inform the design of infant and future food formula. The microbiota profile is also emerging as a biomarker to predict responsiveness to dietary interventions and promises to make personalised nutrition a reality.

  • food
  • microbiome
  • microbiota
  • nutrition

Statistics from Altmetric.com

Footnotes

  • Contributors All authors contributed to the content of the manuscript.

  • Competing interests FS is a co-founder, shareholder in Atlantia Food Clinical Trials, 4D Pharma Cork, Alimentary Health. He is the director of the APC Microbiome Institute, a research centre funded in part by Science Foundation Ireland (APC/SFI/12/RC/2273) and which is/has recently been in receipt of research grants from Abvie, Alimentary Health, Cremo, Danone, Janssen, Friesland Campina, General Mills, Kerry, MeadJohnson, Nutricia, 4D Pharma and Second Genome, and Sigmoid Pharma.

  • Provenance and peer review Commissioned; internally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.