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Germline variation of circadian pathway genes and prognosis of gastric cancer patients
  1. Senthilkumar Rajendran1,
  2. Clara Benna1,
  3. Halenya Monticelli1,
  4. Giovanna Spiro1,
  5. Chiara Menin2,
  6. Simone Mocellin1,2
  1. 1Department of Surgery Oncology and Gastroenterology, University of Padova, Padova, Italy
  2. 2Surgical Oncology Unit, Istituto Oncologico Veneto (IOV-IRCCS), Padova, Italy
  1. Correspondence to Professor Simone Mocellin, Department of Surgery Oncology and Gastroenterology, University of Padova, Via Giustiniani 2, Padova 35128, Italy; simone.mocellin{at}unipd.it

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As we have summarised in this journal,1 germline DNA variation has been long recognised as a key component of the risk to develop to gastric carcinoma, the discovery pace being greatly accelerated by genome-wide association studies.2 More recently, growing evidence is accumulating also on the association between genetic variation and prognosis of patients with gastric cancer.3 4 Furthermore, investigators have demonstrated that alterations of the circadian rhythm can predispose to a variety of illnesses, including different types of malignancies and gastrointestinal diseases.5 6

Putting together these observations, we studied the relationship between circadian genes germline variation and the overall survival of 460 patients with TNM stage I to IV gastric carcinoma. We considered 21 single nucleotide polymorphisms (SNPs) of 14 circadian pathway genes. Genotyping was performed with real-time quantitative PCR using patient peripheral blood samples. Expression quantitative trait locus (eQTL) analysis was employed to …

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