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High prevalence of hepatitis E virus in semen of infertile male and causes testis damage

https://doi.org/10.1136/gutjnl-2017-314884

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    Footnotes

    • FH, FL, WY, JS and LF contributed equally.

    • Contributors FH conceived and supervised the study. JS and FY performed all the HEV detection experiments, analyzed data and wrote a draft of the paper. WY and ZH performed rhesus macaque inoculation and collected tissues. LF and HD collected these clinical samples and performed semen and hormone analysis. JS, CY, YL, FY and DW performed histopathology and immunohistochemistry experiments.

    • Funding This study was supported by National Natural Science Foundation of China (31360619, 81660338 and 31572525), Natural Science Foundation of Yunnan Province (2011FZ068, 2013FB032 and 2017FA036), Fundamental Research Funds for the Central Universities (20162X310179-3) and PUMC youth fund (2017310038).

    • Competing interests None declared.

    • Ethics approval Kunming University of Science and Technology.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Author note We added DW’s contribution.