Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have been proposed, but most ultimately failed in phase III trials. This manuscript targets therapeutic advances and most burning issues. Expert key point summaries and urgent research agenda are provided regarding risk factors, including microbiota, need for prognostic and predictive biomarkers and the equivocal role of liver biopsy. Therapeutic topics highlighted are locoregional techniques, combination therapies and the potential of immunotherapy. Finally the manuscript provides a critical evaluation of novel targets and strategies for personalized treatment of HCC.
- hepatocellular carcinoma
- clinical trials
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Contributors All authors were involved in drafting and reviewing the manuscript and had approval of the final version submitted.
Competing interests J-FD Advisory committees: Abbvie, Bayer, BMS, Falk, Genfit, GileadScience, Intercept, Lilly, Merck, Novartis. Speaking and teaching: Abbvie, Bayer, BMS, Genfit, Gilead Science, Novartis. Unrestricted research grant: Bayer. JB Consultancy for Abbvie, Arqule, Bayer, BMS, Boehringer Ingelheim BTG, Eisai,Gilead, Kowa, Novartis, Onxeo, Roche, Sirtex andTerumo. Research contract with Bayer. M P-R Investigator: Abbott, Arqle-Daiichi, Bayer, BMS, Boehringer-Ingelheim, Gilead, Imclone, Novartis, Roche. Speaker, Advisor: Abbott, Bayer, BMS, Boehringer-Ingelheim, Gilead, MSD, Roche. Grant Support: Abbott, Bayer, Gilead, MSD, Roche. DSMB: Lilly-Imclone, ONXEO. RS Advisor to Bayer, BTG, Terumo, Merit, Cook. PRG Honoraria for lecturing and participation in advisory boards from Bayer, Lilly, Sirtex, Sillajen, BMS, MSD.
Provenance and peer review Not commissioned; externally peer reviewed.
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