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Letter
Coeliac biopsies: numbers are valid, alphabets not
  1. Kamran Rostami1,
  2. Arzu Ensari2,
  3. Carolina Ciacci3,
  4. Amitabh Srivastava4,
  5. Umberto Volta5,
  6. Vincenzo Villanacci6,
  7. Michael N Marsh7,8
  1. 1Department of Gastroenterology, Milton Keynes Hospital NHS Foundation Trust, Milton Keynes, UK
  2. 2Department of Pathology, Ankara University Medical School, Ankara, Turkey
  3. 3Department of Medicine and Surgery, Scuola Medica Salernitana, University of Salerno, Salerno, Italy
  4. 4Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
  5. 5Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
  6. 6Department of Pathology, Institute of Pathology Spedali Civili, Brescia, Italy
  7. 7Department of Gastroenterology, Luton and Dunstable University Hospital, Luton, UK
  8. 8Wolfson College, University of Oxford, Oxford, United Kingdom
  1. Correspondence to Dr Kamran Rostami, Department of Gastroenterology, Milton Keynes University Hospital, Standing Way, Eaglestone, Milton Keynes MK6 5LD, UK; kamran.rostami{at}nhs.net

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We thank Gut for requesting responses to this letter from Oberhuber and colleagues.1 We were amazed that they chose to dismiss our intraepithelial lymphocytes (IEL) data as invalid2 on grounds of not being age/gender matched with controls. But this disregards all the other data of clinicians and pathologists in the field, and the rigorous reviewing processes that our article went through before publication in Gut. This dismissal reflects an aberrant viewpoint1 lacking widespread support. In real life, pathologists do sign off biopsies, while diagnoses are rendered without full clinical details, although with appropriately worded caveats.

We aimed, specifically, to reduce the enormous …

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