Article Text

PDF
Letter
Role of thiopurines as disease-modifying agents in Crohn’s disease
  1. Jonathan Blackwell1,
  2. Sonia Saxena2,
  3. Richard C Pollok1
  1. 1Department of Gastroenterology, St George’s NHS Foundation Trust, London, UK
  2. 2Department of Primary Care and Public Health, Imperial College, London, UK
  1. Correspondence to Dr Jonathan Blackwell, Department of Gastroenterology, St George’s NHS Foundation Trust, St George’s Hospital, London, SW17 0QT, UK; jonnyblackwell{at}gmail.com

Statistics from Altmetric.com

We agree with Danese et al1 that prospective studies to evaluate the disease-modifying action of antitumour necrosis factor (anti-TNF) drugs are overdue. As a counterpoint to this informative review, we would like to highlight some additional evidence for the role of thiopurines as disease-modifying agents in Crohn’s disease. A cohort study by Magro et al2 supports a role for thiopurines in delaying phenotype progression from an inflammatory (B1) to a stricturing/penetrating (B2/B3) disease (HR 0.15, 95% CI 0.11 to 0.19). A meta-analysis of 10 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.