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Letter
Several aspects in study design need further consideration
  1. Cheng-Bei Zhou,
  2. Jing-Yuan Fang
  1. Division of Gastroenterology and Hepatology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Gene, Shanghai Institute of Digestive Disease, Shanghai, China
  1. Correspondence to Dr Jing-Yuan Fang, Division of Gastroenterology and Hepatology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Gene, Shanghai Institute of Digestive Disease, Shanghai, 200001, China; jingyuanfang{at}sjtu.edu.cn

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We read with interest the work by Cheung et al1 describing that patients with prior Helicobacter pylori eradication therapy receiving long-term proton pump inhibitors (PPIs) therapy are still at enhanced risk of gastric cancer development, particularly for non-cardia cancer. As the current consensus report stated, long-term treatment with PPIs in H. pylori-positive patients accelerates the process of loss of specialised glands, leading to atrophic gastritis. Hence, it is recommended that eradication of H. pylori heals gastritis in patients …

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