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Hepatology
Original article
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

Authors

  • Maria J Perugorria Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain IKERBASQUE, Basque Foundation for Science, Bilbao, Spain CIBERehd, Instituto de Salud Carlos III, San Sebastián, Spain PubMed articlesGoogle scholar articles
  • Aitor Esparza-Baquer Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain PubMed articlesGoogle scholar articles
  • Fiona Oakley Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Ibone Labiano Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain PubMed articlesGoogle scholar articles
  • Ana Korosec CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria PubMed articlesGoogle scholar articles
  • Alexander Jais Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria PubMed articlesGoogle scholar articles
  • Jelena Mann Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Dina Tiniakos Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  • Alvaro Santos-Laso Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain PubMed articlesGoogle scholar articles
  • Ander Arbelaiz Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain PubMed articlesGoogle scholar articles
  • Riem Gawish CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria PubMed articlesGoogle scholar articles
  • Ana Sampedro Hepatology Programme, CIMA, University of Navarra, Pamplona, Spain PubMed articlesGoogle scholar articles
  • Antonio Fontanellas Hepatology Programme, CIMA, University of Navarra, Pamplona, Spain PubMed articlesGoogle scholar articles
  • Elizabeth Hijona Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain CIBERehd, Instituto de Salud Carlos III, San Sebastián, Spain PubMed articlesGoogle scholar articles
  • Raul Jimenez-Agüero Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain PubMed articlesGoogle scholar articles
  • Harald Esterbauer Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria PubMed articlesGoogle scholar articles
  • Dagmar Stoiber Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria PubMed articlesGoogle scholar articles
  • Luis Bujanda Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain CIBERehd, Instituto de Salud Carlos III, San Sebastián, Spain PubMed articlesGoogle scholar articles
  • Jesus María Banales Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), San Sebastian, Spain IKERBASQUE, Basque Foundation for Science, Bilbao, Spain CIBERehd, Instituto de Salud Carlos III, San Sebastián, Spain PubMed articlesGoogle scholar articles
  • Sylvia Knapp CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria PubMed articlesGoogle scholar articles
  • Omar Sharif CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria PubMed articlesGoogle scholar articles
  • Derek A Mann Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Maria J Perugorria, Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), CIBERehd, 20014 San Sebastian, Spain; matxus.perugorria{at}biodonostia.org, Dr Omar Sharif, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Department of Medicine I, Laboratory of Infection Biology, Medical University of Vienna, and Ludwig Boltzmann Institute for Cancer Research, 1090 Vienna, Austria ; Omar.Sharif{at}lbicr.lbg.ac.at and Prof Derek A Mann, Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, 4th Floor, William Leech Building, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK; derek.mann{at}newcastle.ac.uk
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Citation

Perugorria MJ, Esparza-Baquer A, Oakley F, et al
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage
Gut 2019;68:533-546.

Publication history

  • Received March 7, 2017
  • Revised December 26, 2017
  • Accepted December 28, 2017
  • First published January 27, 2018.
Online issue publication 
March 19, 2019

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.