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Association between proton pump inhibitors use and risk of gastric cancer in patients with GERD
  1. Yen-Chun Peng1,2,
  2. Lam-Ru Huang3,
  3. Cheng-Li Lin4,5,
  4. Wan-Yun Hsu6,
  5. Chi-Sen Chang1,
  6. Hong-Zen Yeh1,2,
  7. Chia-Hung Kao7,8,9
  1. 1Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
  2. 2National Yang-Ming University, Taipei, Taiwan
  3. 3Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
  4. 4Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
  5. 5College of Medicine, China Medical University, Taichung, Taiwan
  6. 6Department of Nursing, Taichung Veterans General Hospital, Taichung, Taiwan
  7. 7Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
  8. 8Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
  9. 9Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan
  1. Correspondence to Professor Chia-Hung Kao, Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University,Taichung 404, Taiwan; d10040{at}mail.cmuh.org.tw

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We read with interest the study by Cheung et al confirming the risk of proton pump inhibitors (PPIs) for gastric cancer regarding the patients after Helicobacter pylori (H. pylori) eradication with long-term PPIs use.1 Most concerns about the safety of PPIs pertain to the increased risk for enteric infections, fractures and nutritional deficiencies.2 To date, the association of PPIs use and risk of gastric cancer is still controversial in patients with gastro-oesophageal reflux diseases (GERD).

For GERD, PPIs are the mainstay of treatment in the management of patients with acid-related disorders.3 Thus, patients with GERD usually take long-term PPIs,and possibly carry the risk of gastric cancer. In the present study, we performed a case–control study to investigate the association of PPIs use and risk of gastric cancer using data from a nationwide population database, the National Health Insurance Research Database (NHIRD) in Taiwan.4

This study also used a subdataset of the NHIRD, which comprises one million randomly sampled beneficiaries enrolled in the NHI programme in 2000 (Longitudinal Health Insurance Database …

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