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October 1998 (Volume 43, 4). [Index by author]

	(Expand the cover)	LEADING ARTICLES COMMENTARIES SCIENCE ALERTS OESOPHAGUS STOMACH SMALL INTESTINE COELIAC DISEASE AND DERMATITIS HERPETIFORMIS INFLAMMATION AND INFLAMMATORY BOWEL DISEASE MOLECULAR GASTROENTEROLOGY MOTILITY COLORECTAL CANCER PANCREAS AND BILIARY TRACT CASE REPORTS REVIEWS LETTERS TO THE EDITOR BOOK REVIEWS

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LEADING ARTICLES

Can immunotherapy by gene transfer tip the balance against colorectal cancer?
S M TODRYK, H CHONG, R G VILE, H PANDHA, and N R LEMOINE
Gut 1998; 43: 445-449. doi:10.1136/gut.43.4.445 [Abstract] [Full text] [PDF] [Request Permissions]

COMMENTARIES

Genetic instability in colorectal cancer
H J W THOMAS
Gut 1998; 43: 450-451. doi:10.1136/gut.43.4.450 [Extract] [Full text] [PDF] [Request Permissions]

Appendicectomy and childhood hygiene: different sides of the same coin?
A EKBOM
Gut 1998; 43: 451. doi:10.1136/gut.43.4.451 [Extract] [Full text] [Request Permissions]

AFAP: variety is the spice of life
H T LYNCH and P WATSON
Gut 1998; 43: 451. doi:10.1136/gut.43.4.451a [Extract] [Full text] [Request Permissions]

Swallowing is a precarious business
J A WILSON
Gut 1998; 43: 453-454. doi:10.1136/gut.43.4.453 [Extract] [Full text] [Request Permissions]

Cholecystokinin infusion: assessing a rather provocative test
D AL-MUSAWI and R C N WILLIAMSON
Gut 1998; 43: 454-455. doi:10.1136/gut.43.4.454 [Extract] [Full text] [Request Permissions]

SCIENCE ALERTS

The medium is the messenger
A D PHILLIPS
Gut 1998; 43: 456-457. doi:10.1136/gut.43.4.456 [Extract] [Full text] [PDF] [Request Permissions]

OESOPHAGUS

Erosive oesophagitis: outcome of repeated long term maintenance treatment with low dose omeprazole 10 mg or placebo
K D Bardhan, P Cherian, A Vaishnavi, R B Jones, M Thompson, P Morris, A Brooks, J D'Silva, K R W Gillon, C Wason, J Patterson, J Polak, and A Bishop
Gut 1998; 43: 458-464. doi:10.1136/gut.43.4.458 [Abstract] [Full text] [PDF] [Request Permissions]

STOMACH

Age and Helicobacter pylori decrease gastric mucosal surface hydrophobicity independently
A Hackelsberger, U Platzer, M Nilius, V Schultze, T Günther, J E Dominguez-Muñoz, and P Malfertheiner
Gut 1998; 43: 465-469. doi:10.1136/gut.43.4.465 [Abstract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised
J L Newton, N Jordan, L Oliver, V Strugala, J Pearson, O F W James, and A Allen
Gut 1998; 43: 470-475. doi:10.1136/gut.43.4.470 [Abstract] [Full text] [PDF] [Request Permissions]

Gastric involvement in AIDS associated cryptosporidiosis
P Rossi, F Rivasi, M Codeluppi, A Catania, A Tamburrini, E Righi, and E Pozio
Gut 1998; 43: 476-477. doi:10.1136/gut.43.4.476 [Abstract] [Full text] [PDF] [Request Permissions]

SMALL INTESTINE

The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection
P B Jeppesen and P B Mortensen
Gut 1998; 43: 478-483. doi:10.1136/gut.43.4.478 [Abstract] [Full text] [PDF] [Request Permissions]

COELIAC DISEASE AND DERMATITIS HERPETIFORMIS

Gliadin activates mucosal cell mediated immunity in cultured rectal mucosa from coeliac patients and a subset of their siblings
R Troncone, G Mazzarella, N Leone, M Mayer, M De Vincenzi, L Greco, and S Auricchio
Gut 1998; 43: 484-489. doi:10.1136/gut.43.4.484 [Abstract] [Full text] [PDF] [Request Permissions]

Tolerance to oats in dermatitis herpetiformis
T Reunala, P Collin, K Holm, P Pikkarainen, A Miettinen, N Vuolteenaho, and M Mäki
Gut 1998; 43: 490-493. doi:10.1136/gut.43.4.490 [Abstract] [Full text] [PDF] [Request Permissions]

INFLAMMATION AND INFLAMMATORY BOWEL DISEASE

Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: a case control study
A E Duggan, I Usmani, K R Neal, and R F A Logan
Gut 1998; 43: 494-498. doi:10.1136/gut.43.4.494 [Abstract] [Full text] [PDF] [Request Permissions]

Increased state of activation of CD4 positive T cells and elevated interferon $gamma$ production in pouchitis
A Stallmach, F Schäfer, S Hoffmann, S Weber, I Müller-Molaian, T Schneider, G Köhne, K-W Ecker, G Feifel, and M Zeitz
Gut 1998; 43: 499-505. doi:10.1136/gut.43.4.499 [Abstract] [Full text] [PDF] [Request Permissions]

Intestinal permeability and inflammation in patients on NSAIDs
G Sigthorsson, J Tibble, J Hayllar, I Menzies, A Macpherson, R Moots, D Scott, M J Gumpel, and I Bjarnason
Gut 1998; 43: 506-511. doi:10.1136/gut.43.4.506 [Abstract] [Full text] [PDF] [Request Permissions]

Hyperbaric oxygen: a novel modality to ameliorate experimental colitis
D Rachmilewitz, F Karmeli, E Okon, I Rubenstein, and O S Better
Gut 1998; 43: 512-518. doi:10.1136/gut.43.4.512 [Abstract] [Full text] [PDF] [Request Permissions]

MOLECULAR GASTROENTEROLOGY

Mucin gene expression in human embryonic and fetal intestine
M P Buisine, L Devisme, T C Savidge, C Gespach, B Gosselin, N Porchet, and J P Aubert
Gut 1998; 43: 519-524. doi:10.1136/gut.43.4.519 [Abstract] [Full text] [PDF] [Request Permissions]

Expression of basic fibroblast growth factor in intact and ulcerated human gastric mucosa
M A Hull, J L Brough, D G Powe, G I Carter, D Jenkins, and C J Hawkey
Gut 1998; 43: 525-536. doi:10.1136/gut.43.4.525 [Abstract] [Full text] [PDF] [Request Permissions]

MOTILITY

Effect of chronic and acute cigarette smoking on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow
K Dua, E Bardan, J Ren, Z Sui, and R Shaker
Gut 1998; 43: 537-541. doi:10.1136/gut.43.4.537 [Abstract] [Full text] [PDF] [Request Permissions]

Oncological implications of RET gene mutations in Hirschsprung's disease
R H Sijmons, R M W Hofstra, F A Wijburg, T P Links, R P Zwierstra, A Vermey, D C Aronson, G Tan-Sindhunata, G J Brouwers-Smalbraak, S M Maas, and C H C M Buys
Gut 1998; 43: 542-547. doi:10.1136/gut.43.4.542 [Abstract] [Full text] [PDF] [Request Permissions]

COLORECTAL CANCER

Variable phenotype of familial adenomatous polyposis in pedigrees with 3' mutation in the APC gene
J D Brensinger, S J Laken, M C Luce, S M Powell, G H Vance, D J Ahnen, G M Petersen, S R Hamilton, and F M Giardiello
Gut 1998; 43: 548-552. doi:10.1136/gut.43.4.548 [Abstract] [Full text] [PDF] [Request Permissions]

Frequency of replication errors in colorectal cancer and their association with family history
S R Brown, P J Finan, L Cawkwell, P Quirke, and D T Bishop
Gut 1998; 43: 553-557. doi:10.1136/gut.43.4.553 [Abstract] [Full text] [PDF] [Request Permissions]

PANCREAS AND BILIARY TRACT

Pancreatic dysfunction and its association with fat malabsorption in HIV infected children
A Carroccio, M Fontana, M I Spagnuolo, G Zuin, G Montalto, R B Canani, F Verghi, D Di Martino, K Bastoni, F Buffardi, and A Guarino
Gut 1998; 43: 558-563. doi:10.1136/gut.43.4.558 [Abstract] [Full text] [PDF] [Request Permissions]

Increased nitric oxide activity in a rat model of acute pancreatitis
R A Al-Mufti, R C N Williamson, and R T Mathie
Gut 1998; 43: 564-570. doi:10.1136/gut.43.4.564 [Abstract] [Full text] [PDF] [Request Permissions]

A requiem for the cholecystokinin provocation test?
A Smythe, A W Majeed, M Fitzhenry, and A G Johnson
Gut 1998; 43: 571-574. doi:10.1136/gut.43.4.571 [Abstract] [Full text] [PDF] [Request Permissions]

CASE REPORTS

Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis
K Ohba, K Omagari, T Nakamura, N Ikuno, S Saeki, I Matsuo, H Kinoshita, J Masuda, H Hazama, I Sakamoto, and S Kohno
Gut 1998; 43: 575-577. doi:10.1136/gut.43.4.575 [Abstract] [Full text] [PDF] [Request Permissions]

REVIEWS

Chemoprevention of colorectal cancer
M LANGMAN and P BOYLE
Gut 1998; 43: 578-585. doi:10.1136/gut.43.4.578 [Abstract] [Full text] [PDF] [Request Permissions]

LETTERS TO THE EDITOR

Influence of metronidazole resistance on efficacy of quadruple therapy for Helicobacter pylori eradication • Reply
M C BATESON, R W M VAN DER HULST, A HOMAN, G N J TYTGAT, A VAN DER ENDE, P ROORDA, and J DANKERT
Gut 1998; 43: 586. doi:10.1136/gut.43.4.586 [Extract] [Full text] [PDF] [Request Permissions]

The buried bumper syndrome: a complication of percutaneous endoscopic gastrostomy
R SHEERS and S CHAPMAN
Gut 1998; 43: 586. doi:10.1136/gut.43.4.586a [Extract] [Full text] [Request Permissions]

Screening young people for gastric cancer • Reply
D KARAT, J WAYMAN, N HAYES, S A RAIMES, S M GRIFFIN, R VALORI, and N A SHEPHERD
Gut 1998; 43: 586. doi:10.1136/gut.43.4.586b [Extract] [Full text] [Request Permissions]

Activation of NF $kappa$ B in inflammatory bowel disease • Reply
R M SCHMID, G ADLER, S LIPTAY, S SCHREIBER, S NIKOLAUS, and J HAMPE
Gut 1998; 43: 586. doi:10.1136/gut.43.4.586c [Extract] [Full text] [Request Permissions]

BOOK REVIEWS

Pancreatitis
A N KINGSNORTH
Gut 1998; 43: 586. doi:10.1136/gut.43.4.586d [Extract] [Full text] [Request Permissions]

Current Studies in Haematology and Blood Transfusion. Volume 62. Hepatitis C Virus
M THURSZ
Gut 1998; 43: 586. doi:10.1136/gut.43.4.e586 [Extract] [Full text] [Request Permissions]

Shared Care in Gastroenterology
P HUNGIN
Gut 1998; 43: 586. doi:10.1136/gut.43.4.586f [Extract] [Full text] [Request Permissions]

Diagnosis and Treatment of Hepatocellular Carcinoma
P JOHNSON
Gut 1998; 43: 586. doi:10.1136/gut.43.4.586g [Extract] [Full text] [Request Permissions]

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	Can immunotherapy by gene transfer tip the balance against colorectal cancer? S M TODRYK, H CHONG, R G VILE, H PANDHA, and N R LEMOINE Gut 1998; 43: 445-449. doi:10.1136/gut.43.4.445 [Abstract] [Full text] [PDF] [Request Permissions]

	Genetic instability in colorectal cancer H J W THOMAS Gut 1998; 43: 450-451. doi:10.1136/gut.43.4.450 [Extract] [Full text] [PDF] [Request Permissions]

	Appendicectomy and childhood hygiene: different sides of the same coin? A EKBOM Gut 1998; 43: 451. doi:10.1136/gut.43.4.451 [Extract] [Full text] [Request Permissions]

	AFAP: variety is the spice of life H T LYNCH and P WATSON Gut 1998; 43: 451. doi:10.1136/gut.43.4.451a [Extract] [Full text] [Request Permissions]

	Swallowing is a precarious business J A WILSON Gut 1998; 43: 453-454. doi:10.1136/gut.43.4.453 [Extract] [Full text] [Request Permissions]

	Cholecystokinin infusion: assessing a rather provocative test D AL-MUSAWI and R C N WILLIAMSON Gut 1998; 43: 454-455. doi:10.1136/gut.43.4.454 [Extract] [Full text] [Request Permissions]

	The medium is the messenger A D PHILLIPS Gut 1998; 43: 456-457. doi:10.1136/gut.43.4.456 [Extract] [Full text] [PDF] [Request Permissions]

	Erosive oesophagitis: outcome of repeated long term maintenance treatment with low dose omeprazole 10 mg or placebo K D Bardhan, P Cherian, A Vaishnavi, R B Jones, M Thompson, P Morris, A Brooks, J D'Silva, K R W Gillon, C Wason, J Patterson, J Polak, and A Bishop Gut 1998; 43: 458-464. doi:10.1136/gut.43.4.458 [Abstract] [Full text] [PDF] [Request Permissions]

	*Age and Helicobacter pylori* decrease gastric mucosal surface hydrophobicity independently** A Hackelsberger, U Platzer, M Nilius, V Schultze, T Günther, J E Dominguez-Muñoz, and P Malfertheiner Gut 1998; 43: 465-469. doi:10.1136/gut.43.4.465 [Abstract] [Full text] [PDF] [Request Permissions]

	Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised J L Newton, N Jordan, L Oliver, V Strugala, J Pearson, O F W James, and A Allen Gut 1998; 43: 470-475. doi:10.1136/gut.43.4.470 [Abstract] [Full text] [PDF] [Request Permissions]

	Gastric involvement in AIDS associated cryptosporidiosis P Rossi, F Rivasi, M Codeluppi, A Catania, A Tamburrini, E Righi, and E Pozio Gut 1998; 43: 476-477. doi:10.1136/gut.43.4.476 [Abstract] [Full text] [PDF] [Request Permissions]

	The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection P B Jeppesen and P B Mortensen Gut 1998; 43: 478-483. doi:10.1136/gut.43.4.478 [Abstract] [Full text] [PDF] [Request Permissions]

	Gliadin activates mucosal cell mediated immunity in cultured rectal mucosa from coeliac patients and a subset of their siblings R Troncone, G Mazzarella, N Leone, M Mayer, M De Vincenzi, L Greco, and S Auricchio Gut 1998; 43: 484-489. doi:10.1136/gut.43.4.484 [Abstract] [Full text] [PDF] [Request Permissions]

	Tolerance to oats in dermatitis herpetiformis T Reunala, P Collin, K Holm, P Pikkarainen, A Miettinen, N Vuolteenaho, and M Mäki Gut 1998; 43: 490-493. doi:10.1136/gut.43.4.490 [Abstract] [Full text] [PDF] [Request Permissions]

	*Appendicectomy, childhood hygiene, Helicobacter pylori* status, and risk of inflammatory bowel disease: a case control study** A E Duggan, I Usmani, K R Neal, and R F A Logan Gut 1998; 43: 494-498. doi:10.1136/gut.43.4.494 [Abstract] [Full text] [PDF] [Request Permissions]

	Increased state of activation of CD4 positive T cells and elevated interferon $gamma$ production in pouchitis A Stallmach, F Schäfer, S Hoffmann, S Weber, I Müller-Molaian, T Schneider, G Köhne, K-W Ecker, G Feifel, and M Zeitz Gut 1998; 43: 499-505. doi:10.1136/gut.43.4.499 [Abstract] [Full text] [PDF] [Request Permissions]

	Intestinal permeability and inflammation in patients on NSAIDs G Sigthorsson, J Tibble, J Hayllar, I Menzies, A Macpherson, R Moots, D Scott, M J Gumpel, and I Bjarnason Gut 1998; 43: 506-511. doi:10.1136/gut.43.4.506 [Abstract] [Full text] [PDF] [Request Permissions]

	Hyperbaric oxygen: a novel modality to ameliorate experimental colitis D Rachmilewitz, F Karmeli, E Okon, I Rubenstein, and O S Better Gut 1998; 43: 512-518. doi:10.1136/gut.43.4.512 [Abstract] [Full text] [PDF] [Request Permissions]

	Mucin gene expression in human embryonic and fetal intestine M P Buisine, L Devisme, T C Savidge, C Gespach, B Gosselin, N Porchet, and J P Aubert Gut 1998; 43: 519-524. doi:10.1136/gut.43.4.519 [Abstract] [Full text] [PDF] [Request Permissions]

	Expression of basic fibroblast growth factor in intact and ulcerated human gastric mucosa M A Hull, J L Brough, D G Powe, G I Carter, D Jenkins, and C J Hawkey Gut 1998; 43: 525-536. doi:10.1136/gut.43.4.525 [Abstract] [Full text] [PDF] [Request Permissions]

	Effect of chronic and acute cigarette smoking on the pharyngo-upper oesophageal sphincter contractile reflex and reflexive pharyngeal swallow K Dua, E Bardan, J Ren, Z Sui, and R Shaker Gut 1998; 43: 537-541. doi:10.1136/gut.43.4.537 [Abstract] [Full text] [PDF] [Request Permissions]

	Oncological implications of RET gene mutations in Hirschsprung's disease R H Sijmons, R M W Hofstra, F A Wijburg, T P Links, R P Zwierstra, A Vermey, D C Aronson, G Tan-Sindhunata, G J Brouwers-Smalbraak, S M Maas, and C H C M Buys Gut 1998; 43: 542-547. doi:10.1136/gut.43.4.542 [Abstract] [Full text] [PDF] [Request Permissions]

	Variable phenotype of familial adenomatous polyposis in pedigrees with 3' mutation in the APC gene J D Brensinger, S J Laken, M C Luce, S M Powell, G H Vance, D J Ahnen, G M Petersen, S R Hamilton, and F M Giardiello Gut 1998; 43: 548-552. doi:10.1136/gut.43.4.548 [Abstract] [Full text] [PDF] [Request Permissions]

	Frequency of replication errors in colorectal cancer and their association with family history S R Brown, P J Finan, L Cawkwell, P Quirke, and D T Bishop Gut 1998; 43: 553-557. doi:10.1136/gut.43.4.553 [Abstract] [Full text] [PDF] [Request Permissions]

	Pancreatic dysfunction and its association with fat malabsorption in HIV infected children A Carroccio, M Fontana, M I Spagnuolo, G Zuin, G Montalto, R B Canani, F Verghi, D Di Martino, K Bastoni, F Buffardi, and A Guarino Gut 1998; 43: 558-563. doi:10.1136/gut.43.4.558 [Abstract] [Full text] [PDF] [Request Permissions]

	Increased nitric oxide activity in a rat model of acute pancreatitis R A Al-Mufti, R C N Williamson, and R T Mathie Gut 1998; 43: 564-570. doi:10.1136/gut.43.4.564 [Abstract] [Full text] [PDF] [Request Permissions]

	A requiem for the cholecystokinin provocation test? A Smythe, A W Majeed, M Fitzhenry, and A G Johnson Gut 1998; 43: 571-574. doi:10.1136/gut.43.4.571 [Abstract] [Full text] [PDF] [Request Permissions]

	Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis K Ohba, K Omagari, T Nakamura, N Ikuno, S Saeki, I Matsuo, H Kinoshita, J Masuda, H Hazama, I Sakamoto, and S Kohno Gut 1998; 43: 575-577. doi:10.1136/gut.43.4.575 [Abstract] [Full text] [PDF] [Request Permissions]

	Chemoprevention of colorectal cancer M LANGMAN and P BOYLE Gut 1998; 43: 578-585. doi:10.1136/gut.43.4.578 [Abstract] [Full text] [PDF] [Request Permissions]

	*Influence of metronidazole resistance on efficacy of quadruple therapy for Helicobacter pylori* eradication • Reply** M C BATESON, R W M VAN DER HULST, A HOMAN, G N J TYTGAT, A VAN DER ENDE, P ROORDA, and J DANKERT Gut 1998; 43: 586. doi:10.1136/gut.43.4.586 [Extract] [Full text] [PDF] [Request Permissions]

	The buried bumper syndrome: a complication of percutaneous endoscopic gastrostomy R SHEERS and S CHAPMAN Gut 1998; 43: 586. doi:10.1136/gut.43.4.586a [Extract] [Full text] [Request Permissions]

	Screening young people for gastric cancer • Reply D KARAT, J WAYMAN, N HAYES, S A RAIMES, S M GRIFFIN, R VALORI, and N A SHEPHERD Gut 1998; 43: 586. doi:10.1136/gut.43.4.586b [Extract] [Full text] [Request Permissions]

	Activation of NF $kappa$ B in inflammatory bowel disease • Reply R M SCHMID, G ADLER, S LIPTAY, S SCHREIBER, S NIKOLAUS, and J HAMPE Gut 1998; 43: 586. doi:10.1136/gut.43.4.586c [Extract] [Full text] [Request Permissions]

	Pancreatitis A N KINGSNORTH Gut 1998; 43: 586. doi:10.1136/gut.43.4.586d [Extract] [Full text] [Request Permissions]

	Current Studies in Haematology and Blood Transfusion. Volume 62. Hepatitis C Virus M THURSZ Gut 1998; 43: 586. doi:10.1136/gut.43.4.e586 [Extract] [Full text] [Request Permissions]

	Shared Care in Gastroenterology P HUNGIN Gut 1998; 43: 586. doi:10.1136/gut.43.4.586f [Extract] [Full text] [Request Permissions]

	Diagnosis and Treatment of Hepatocellular Carcinoma P JOHNSON Gut 1998; 43: 586. doi:10.1136/gut.43.4.586g [Extract] [Full text] [Request Permissions]