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March 2000 (Volume 46, Number 3). [Index by author]

	(Cover illustration)	LEADING ARTICLES COMMENTARIES SCIENCE ALERTS CLINICAL ALERTS STOMACH COELIAC DISEASE INFLAMMATION AND INFLAMMATORY BOWEL DISEASE CANCER INTESTINAL MOTILITY PANCREATIC AND BILIARY DISEASE LIVER DISEASE CASE REPORTS GUT FILE REVIEWS LETTERS TO THE EDITOR BOOK REVIEWS

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LEADING ARTICLES

Population screening for haemochromatosis
P C ADAMS
Gut 2000; 46: 301-303. doi:10.1136/gut.46.3.301 [Extract] [Full text] [PDF] [Request Permissions]

COMMENTARIES

Microsatellite instability in colitis associated colorectal cancer
S H ITZKOWITZ
Gut 2000; 46: 304-305. doi:10.1136/gut.46.3.304 [Extract] [Full text] [PDF] [Request Permissions]

How should endoscopic accessories be selected: trial or error?
M A NARAIN and R COCKEL
Gut 2000; 46: 305-306. doi:10.1136/gut.46.3.305 [Extract] [Full text] [PDF] [Request Permissions]

Combination of interferon $alpha$ therapy with non-steroidal anti-inflammatory drugs in chronic hepatitis C
S J HADZIYANNIS
Gut 2000; 46: 306-307. doi:10.1136/gut.46.3.306 [Extract] [Full text] [PDF] [Request Permissions]

SCIENCE ALERTS

Bile acids are physiological ligands for a nuclear receptor
J R F WALTERS
Gut 2000; 46: 308-309. doi:10.1136/gut.46.3.308 [Extract] [Full text] [PDF] [Request Permissions]

CLINICAL ALERTS

Risk of ulcer bleeding in patients infected with Helicobacter pylori taking non-steroidal anti-inflammatory drugs
C J HAWKEY
Gut 2000; 46: 310-311. doi:10.1136/gut.46.3.310 [Extract] [Full text] [PDF] [Request Permissions]

STOMACH

The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach
J L Newton, A Allen, B R Westley, and F E B May
Gut 2000; 46: 312-320. doi:10.1136/gut.46.3.312 [Abstract] [Full text] [PDF] [Request Permissions]

Importance of Helicobacter pylori cagA and vacA status for the efficacy of antibiotic treatment
L-J van Doorn, P M Schneeberger, N Nouhan, A P Plaisier, W G V Quint, and W A de Boer
Gut 2000; 46: 321-326. doi:10.1136/gut.46.3.321 [Abstract] [Full text] [PDF] [Request Permissions]

COELIAC DISEASE

Lack of cellular and humoral immunological responses to oats in adults with coeliac disease
E K Janatuinen, T A Kemppainen, P H Pikkarainen, K H Holm, V-M Kosma, M I J Uusitupa, M Mäki, and R J K Julkunen
Gut 2000; 46: 327-331. doi:10.1136/gut.46.3.327 [Abstract] [Full text] [PDF] [Request Permissions]

Coeliac disease and unfavourable outcome of pregnancy
P Martinelli, R Troncone, F Paparo, P Torre, E Trapanese, C Fasano, A Lamberti, G Budillon, G Nardone, and L Greco
Gut 2000; 46: 332-335. doi:10.1136/gut.46.3.332 [Abstract] [Full text] [PDF] [Request Permissions]

INFLAMMATION AND INFLAMMATORY BOWEL DISEASE

Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival
E V Loftus, Jr, M D Silverstein, W J Sandborn, W J Tremaine, W S Harmsen, and A R Zinsmeister
Gut 2000; 46: 336-343. doi:10.1136/gut.46.3.336 [Abstract] [Full text] [PDF] [Request Permissions]

Interleukin 10 gene transfer prevents experimental colitis in rats
G Barbara, Z Xing, C M Hogaboam, J Gauldie, and S M Collins
Gut 2000; 46: 344-349. doi:10.1136/gut.46.3.344 [Abstract] [Full text] [PDF] [Request Permissions]

Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6
R Daig, G Rogler, E Aschenbrenner, D Vogl, W Falk, V Gross, J Schölmerich, and T Andus
Gut 2000; 46: 350-358. doi:10.1136/gut.46.3.350 [Abstract] [Full text] [PDF] [Request Permissions]

CANCER

Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases
T Petretti, W Kemmner, B Schulze, and P M Schlag
Gut 2000; 46: 359-366. doi:10.1136/gut.46.3.359 [Abstract] [Full text] [PDF] [Request Permissions]

Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers
L Cawkwell, F Sutherland, H Murgatroyd, P Jarvis, S Gray, D Cross, N Shepherd, D Day, and P Quirke
Gut 2000; 46: 367-369. doi:10.1136/gut.46.3.367 [Abstract] [Full text] [PDF] [Request Permissions]

INTESTINAL MOTILITY

Pathways and receptors involved in peptide YY induced contraction of rat proximal colonic muscle in vitro
L Ferrier, J-P Segain, P Pacaud, C Cherbut, G Loirand, J-P Galmiche, and H M Blottière
Gut 2000; 46: 370-375. doi:10.1136/gut.46.3.370 [Abstract] [Full text] [PDF] [Request Permissions]

Pressure and frequency dependent linkage between motility and epithelial secretion in human proximal small intestine
A Mellander, K Järbur, and H Sjövall
Gut 2000; 46: 376-384. doi:10.1136/gut.46.3.376 [Abstract] [Full text] [PDF] [Request Permissions]

PANCREATIC AND BILIARY DISEASE

Acute pancreatitis in peritoneal dialysis and haemodialysis: risk, clinical course, outcome, and possible aetiology
M J Bruno, D J van Westerloo, W T van Dorp, W Dekker, J Ferwerda, G N J Tytgat, and N H Schut
Gut 2000; 46: 385-389. doi:10.1136/gut.46.3.385 [Abstract] [Full text] [PDF] [Request Permissions]

Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis
G Eibl, H G Hotz, J Faulhaber, M Kirchengast, H J Buhr, and Th Foitzik
Gut 2000; 46: 390-394. doi:10.1136/gut.46.3.390 [Abstract] [Full text] [PDF] [Request Permissions]

A prospective randomised multicentre trial comparing 10 Fr Teflon Tannenbaum stents with 10 Fr polyethylene Cotton-Leung stents in patients with malignant common duct strictures
R E England, D F Martin, J Morris, M B Sheridan, R Frost, A Freeman, B Lawrie, M Deakin, I Fraser, and K Smith
Gut 2000; 46: 395-400. doi:10.1136/gut.46.3.395 [Abstract] [Full text] [PDF] [Request Permissions]

LIVER DISEASE

Incidence of liver disease in people with HFE mutations
G Willis, J Z Wimperis, R Lonsdale, I W Fellows, M A Watson, L M Skipper, and B A Jennings
Gut 2000; 46: 401-404. doi:10.1136/gut.46.3.401 [Abstract] [Full text] [PDF] [Request Permissions]

Automated measurement of unsaturated iron binding capacity is an effective screening strategy for C282Y homozygous haemochromatosis
P E Hickman, L F Hourigan, L W Powell, F Cordingley, G Dimeski, B Ormiston, J Shaw, W Ferguson, M Johnson, J Ascough, K McDonell, A Pink, and D H G Crawford
Gut 2000; 46: 405-409. doi:10.1136/gut.46.3.405 [Abstract] [Full text] [PDF] [Request Permissions]

Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease
I Nilsson, S Lindgren, S Eriksson, and T Wadström
Gut 2000; 46: 410-414. doi:10.1136/gut.46.3.410 [Abstract] [Full text] [PDF] [Request Permissions]

Diagnosis of Wilson's disease: an experience over three decades
P J Gow, R A Smallwood, P W Angus, A L Smith, A J Wall, and R B Sewell
Gut 2000; 46: 415-419. doi:10.1136/gut.46.3.415 [Abstract] [Full text] [PDF] [Request Permissions]

Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B
G Fattovich, G Giustina, E Christensen, M Pantalena, I Zagni, G Realdi, and S W Schalm
Gut 2000; 46: 420-426. doi:10.1136/gut.46.3.420 [Abstract] [Full text] [PDF] [Request Permissions]

Interferon- $alpha$ 2b combined with daily ketoprofen administration improves virological response in chronic hepatitis C: a prospective and randomised trial
A E Muñoz, D Levi, A Podestá, J Monti Gorín, J González, M A Bartellini, M S Munne, A Cabanne, D Flichman, and R Terg
Gut 2000; 46: 427-431. doi:10.1136/gut.46.3.427 [Abstract] [Full text] [PDF] [Request Permissions]

CASE REPORTS

Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus
E Ichiishi, T Yoshikawa, T Kogawa, N Yoshida, and M Kondo
Gut 2000; 46: 432-434. doi:10.1136/gut.46.3.432 [Abstract] [Full text] [PDF] [Request Permissions]

GUT FILE

Lidocaine toxicity in a student undergoing upper gastrointestinal endoscopy
B F ZUBERI, M R SHAIKH, N-U-N JATOI, and W M SHAIKH
Gut 2000; 46: 435. doi:10.1136/gut.46.3.435 [Extract] [Full text] [PDF] [Request Permissions]

REVIEWS

Peroxynitrite and inflammatory bowel disease
D M McCAFFERTY
Gut 2000; 46: 436-439. doi:10.1136/gut.46.3.436 [Extract] [Full text] [PDF] [Request Permissions]

LETTERS TO THE EDITOR

Colorectal neoplasia in acromegaly: the reported increased prevalence is overestimated • Reply
A G RENEHAN, S T O'DWYER, S M SHALET;, P JENKINS, P FAIRCLOUGH, and M BESSER
Gut 2000; 46: 440. doi:10.1136/gut.46.3.440 [Extract] [Full text] [PDF] [Request Permissions]

Diversion colitis: a trigger for ulcerative colitis in the instream colon
A G LIM and W LIM
Gut 2000; 46: 440. doi:10.1136/gut.46.3.440a [Extract] [Full text] [PDF] [Request Permissions]

Gastric antral vascular ectasia and its relation with portal hypertension • Reply
N C FISHER; and G POMIER-LAYRARGUES
Gut 2000; 46: 440. doi:10.1136/gut.46.3.440b [Extract] [Full text] [PDF] [Request Permissions]

BOOK REVIEWS

ABC of Colorectal Diseases.
A LEATHER
Gut 2000; 46: 440. doi:10.1136/gut.46.3.440c [Extract] [Full text] [PDF] [Request Permissions]

Key Topics in Gastroenterology.
J MEENAN
Gut 2000; 46: 440. doi:10.1136/gut.46.3.440d [Extract] [Full text] [PDF] [Request Permissions]

Cover

Staining of cryostat sections of normal human gastric antral mucosa with anti-TFF1 antibodies showing an intense immunoreactionin the cytoplasm and mucus granules of the epithelial cells ofthe foveolus and of the mucus layer. (From the paper by Newtonet al, pp 312-320.)

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	Population screening for haemochromatosis P C ADAMS Gut 2000; 46: 301-303. doi:10.1136/gut.46.3.301 [Extract] [Full text] [PDF] [Request Permissions]

	Microsatellite instability in colitis associated colorectal cancer S H ITZKOWITZ Gut 2000; 46: 304-305. doi:10.1136/gut.46.3.304 [Extract] [Full text] [PDF] [Request Permissions]

	How should endoscopic accessories be selected: trial or error? M A NARAIN and R COCKEL Gut 2000; 46: 305-306. doi:10.1136/gut.46.3.305 [Extract] [Full text] [PDF] [Request Permissions]

	Combination of interferon $alpha$ therapy with non-steroidal anti-inflammatory drugs in chronic hepatitis C S J HADZIYANNIS Gut 2000; 46: 306-307. doi:10.1136/gut.46.3.306 [Extract] [Full text] [PDF] [Request Permissions]

	Bile acids are physiological ligands for a nuclear receptor J R F WALTERS Gut 2000; 46: 308-309. doi:10.1136/gut.46.3.308 [Extract] [Full text] [PDF] [Request Permissions]

	*Risk of ulcer bleeding in patients infected with Helicobacter pylori* taking non-steroidal anti-inflammatory drugs** C J HAWKEY Gut 2000; 46: 310-311. doi:10.1136/gut.46.3.310 [Extract] [Full text] [PDF] [Request Permissions]

	The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach J L Newton, A Allen, B R Westley, and F E B May Gut 2000; 46: 312-320. doi:10.1136/gut.46.3.312 [Abstract] [Full text] [PDF] [Request Permissions]

	*Importance of Helicobacter pylori cagA* and vacA status for the efficacy of antibiotic treatment** L-J van Doorn, P M Schneeberger, N Nouhan, A P Plaisier, W G V Quint, and W A de Boer Gut 2000; 46: 321-326. doi:10.1136/gut.46.3.321 [Abstract] [Full text] [PDF] [Request Permissions]

	Lack of cellular and humoral immunological responses to oats in adults with coeliac disease E K Janatuinen, T A Kemppainen, P H Pikkarainen, K H Holm, V-M Kosma, M I J Uusitupa, M Mäki, and R J K Julkunen Gut 2000; 46: 327-331. doi:10.1136/gut.46.3.327 [Abstract] [Full text] [PDF] [Request Permissions]

	Coeliac disease and unfavourable outcome of pregnancy P Martinelli, R Troncone, F Paparo, P Torre, E Trapanese, C Fasano, A Lamberti, G Budillon, G Nardone, and L Greco Gut 2000; 46: 332-335. doi:10.1136/gut.46.3.332 [Abstract] [Full text] [PDF] [Request Permissions]

	Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival E V Loftus, Jr, M D Silverstein, W J Sandborn, W J Tremaine, W S Harmsen, and A R Zinsmeister Gut 2000; 46: 336-343. doi:10.1136/gut.46.3.336 [Abstract] [Full text] [PDF] [Request Permissions]

	Interleukin 10 gene transfer prevents experimental colitis in rats G Barbara, Z Xing, C M Hogaboam, J Gauldie, and S M Collins Gut 2000; 46: 344-349. doi:10.1136/gut.46.3.344 [Abstract] [Full text] [PDF] [Request Permissions]

	Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6 R Daig, G Rogler, E Aschenbrenner, D Vogl, W Falk, V Gross, J Schölmerich, and T Andus Gut 2000; 46: 350-358. doi:10.1136/gut.46.3.350 [Abstract] [Full text] [PDF] [Request Permissions]

	Altered mRNA expression of glycosyltransferases in human colorectal carcinomas and liver metastases T Petretti, W Kemmner, B Schulze, and P M Schlag Gut 2000; 46: 359-366. doi:10.1136/gut.46.3.359 [Abstract] [Full text] [PDF] [Request Permissions]

	Defective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers L Cawkwell, F Sutherland, H Murgatroyd, P Jarvis, S Gray, D Cross, N Shepherd, D Day, and P Quirke Gut 2000; 46: 367-369. doi:10.1136/gut.46.3.367 [Abstract] [Full text] [PDF] [Request Permissions]

	Pathways and receptors involved in peptide YY induced contraction of rat proximal colonic muscle in vitro L Ferrier, J-P Segain, P Pacaud, C Cherbut, G Loirand, J-P Galmiche, and H M Blottière Gut 2000; 46: 370-375. doi:10.1136/gut.46.3.370 [Abstract] [Full text] [PDF] [Request Permissions]

	Pressure and frequency dependent linkage between motility and epithelial secretion in human proximal small intestine A Mellander, K Järbur, and H Sjövall Gut 2000; 46: 376-384. doi:10.1136/gut.46.3.376 [Abstract] [Full text] [PDF] [Request Permissions]

	Acute pancreatitis in peritoneal dialysis and haemodialysis: risk, clinical course, outcome, and possible aetiology M J Bruno, D J van Westerloo, W T van Dorp, W Dekker, J Ferwerda, G N J Tytgat, and N H Schut Gut 2000; 46: 385-389. doi:10.1136/gut.46.3.385 [Abstract] [Full text] [PDF] [Request Permissions]

	Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis G Eibl, H G Hotz, J Faulhaber, M Kirchengast, H J Buhr, and Th Foitzik Gut 2000; 46: 390-394. doi:10.1136/gut.46.3.390 [Abstract] [Full text] [PDF] [Request Permissions]

	A prospective randomised multicentre trial comparing 10 Fr Teflon Tannenbaum stents with 10 Fr polyethylene Cotton-Leung stents in patients with malignant common duct strictures R E England, D F Martin, J Morris, M B Sheridan, R Frost, A Freeman, B Lawrie, M Deakin, I Fraser, and K Smith Gut 2000; 46: 395-400. doi:10.1136/gut.46.3.395 [Abstract] [Full text] [PDF] [Request Permissions]

	Incidence of liver disease in people with HFE mutations G Willis, J Z Wimperis, R Lonsdale, I W Fellows, M A Watson, L M Skipper, and B A Jennings Gut 2000; 46: 401-404. doi:10.1136/gut.46.3.401 [Abstract] [Full text] [PDF] [Request Permissions]

	Automated measurement of unsaturated iron binding capacity is an effective screening strategy for C282Y homozygous haemochromatosis P E Hickman, L F Hourigan, L W Powell, F Cordingley, G Dimeski, B Ormiston, J Shaw, W Ferguson, M Johnson, J Ascough, K McDonell, A Pink, and D H G Crawford Gut 2000; 46: 405-409. doi:10.1136/gut.46.3.405 [Abstract] [Full text] [PDF] [Request Permissions]

	*Serum antibodies to Helicobacter hepaticus* and Helicobacter pylori in patients with chronic liver disease** I Nilsson, S Lindgren, S Eriksson, and T Wadström Gut 2000; 46: 410-414. doi:10.1136/gut.46.3.410 [Abstract] [Full text] [PDF] [Request Permissions]

	Diagnosis of Wilson's disease: an experience over three decades P J Gow, R A Smallwood, P W Angus, A L Smith, A J Wall, and R B Sewell Gut 2000; 46: 415-419. doi:10.1136/gut.46.3.415 [Abstract] [Full text] [PDF] [Request Permissions]

	Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B G Fattovich, G Giustina, E Christensen, M Pantalena, I Zagni, G Realdi, and S W Schalm Gut 2000; 46: 420-426. doi:10.1136/gut.46.3.420 [Abstract] [Full text] [PDF] [Request Permissions]

	Interferon- $alpha$ 2b combined with daily ketoprofen administration improves virological response in chronic hepatitis C: a prospective and randomised trial A E Muñoz, D Levi, A Podestá, J Monti Gorín, J González, M A Bartellini, M S Munne, A Cabanne, D Flichman, and R Terg Gut 2000; 46: 427-431. doi:10.1136/gut.46.3.427 [Abstract] [Full text] [PDF] [Request Permissions]

	Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus E Ichiishi, T Yoshikawa, T Kogawa, N Yoshida, and M Kondo Gut 2000; 46: 432-434. doi:10.1136/gut.46.3.432 [Abstract] [Full text] [PDF] [Request Permissions]

	Lidocaine toxicity in a student undergoing upper gastrointestinal endoscopy B F ZUBERI, M R SHAIKH, N-U-N JATOI, and W M SHAIKH Gut 2000; 46: 435. doi:10.1136/gut.46.3.435 [Extract] [Full text] [PDF] [Request Permissions]

	Peroxynitrite and inflammatory bowel disease D M McCAFFERTY Gut 2000; 46: 436-439. doi:10.1136/gut.46.3.436 [Extract] [Full text] [PDF] [Request Permissions]

	Colorectal neoplasia in acromegaly: the reported increased prevalence is overestimated • Reply A G RENEHAN, S T O'DWYER, S M SHALET;, P JENKINS, P FAIRCLOUGH, and M BESSER Gut 2000; 46: 440. doi:10.1136/gut.46.3.440 [Extract] [Full text] [PDF] [Request Permissions]

	Diversion colitis: a trigger for ulcerative colitis in the instream colon A G LIM and W LIM Gut 2000; 46: 440. doi:10.1136/gut.46.3.440a [Extract] [Full text] [PDF] [Request Permissions]

	Gastric antral vascular ectasia and its relation with portal hypertension • Reply N C FISHER; and G POMIER-LAYRARGUES Gut 2000; 46: 440. doi:10.1136/gut.46.3.440b [Extract] [Full text] [PDF] [Request Permissions]

	ABC of Colorectal Diseases. A LEATHER Gut 2000; 46: 440. doi:10.1136/gut.46.3.440c [Extract] [Full text] [PDF] [Request Permissions]

	Key Topics in Gastroenterology. J MEENAN Gut 2000; 46: 440. doi:10.1136/gut.46.3.440d [Extract] [Full text] [PDF] [Request Permissions]