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April 2000 (Volume 46, Number 4). [Index by author]

	(Cover illustration)	LEADING ARTICLES COMMENTARIES SCIENCE ALERTS STOMACH ENTERIC NERVES INFLAMMATION AND INFLAMMATORY BOWEL DISEASE COLON LIVER DISEASE GALLSTONES CASE REPORTS REVIEWS LETTERS TO THE EDITOR BOOK REVIEWS CORRECTIONS

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LEADING ARTICLES

Is liver fibrosis reversible?
R C BENYON and J P IREDALE
Gut 2000; 46: 443-446. doi:10.1136/gut.46.4.443 [Extract] [Full text] [PDF] [Request Permissions]

COMMENTARIES

The intracellular target of butyrate's actions: HDAC or HDON'T?
P R GIBSON
Gut 2000; 46: 447-448. doi:10.1136/gut.46.4.447 [Extract] [Full text] [PDF] [Request Permissions]

Think cytokines before you drink
S C L GOUGH
Gut 2000; 46: 448-449. doi:10.1136/gut.46.4.448 [Extract] [Full text] [PDF] [Request Permissions]

LKM antibody: getting in some target practice
D VERGANI
Gut 2000; 46: 449-450. doi:10.1136/gut.46.4.449 [Extract] [Full text] [PDF] [Request Permissions]

Combination therapy of hepatitis B
E DOO and J H HOOFNAGLE
Gut 2000; 46: 450-451. doi:10.1136/gut.46.4.450 [Extract] [Full text] [PDF] [Request Permissions]

SCIENCE ALERTS

Uteroglobin deficient mice $---$ a novel animal model for IgA nephropathy?
S POURIA and S J CHALLACOMBE
Gut 2000; 46: 452-453. doi:10.1136/gut.46.4.452 [Extract] [Full text] [PDF] [Request Permissions]

STOMACH

The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach
F E B May, J I Semple, J L Newton, and B R Westley
Gut 2000; 46: 454-459. doi:10.1136/gut.46.4.454 [Abstract] [Full text] [PDF] [Request Permissions]

Atrophic gastritis and Helicobacter pylori infection in outpatients referred for gastroscopy
A Oksanen, P Sipponen, R Karttunen, A Miettinen, L Veijola, S Sarna, and H Rautelin
Gut 2000; 46: 460-463. doi:10.1136/gut.46.4.460 [Abstract] [Full text] [PDF] [Request Permissions]

Detection of upper gastrointestinal cancer in patients taking antisecretory therapy prior to gastroscopy
M G Bramble, Z Suvakovic, and A P S Hungin
Gut 2000; 46: 464-467. doi:10.1136/gut.46.4.464 [Abstract] [Full text] [PDF] [Request Permissions]

ENTERIC NERVES

Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man
J Tack, B Coulie, A Wilmer, A Andrioli, and J Janssens
Gut 2000; 46: 468-473. doi:10.1136/gut.46.4.468 [Abstract] [Full text] [PDF] [Request Permissions]

The 5-HT₃ receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat
C M Kozlowski, A Green, D Grundy, F M Boissonade, and C Bountra
Gut 2000; 46: 474-480. doi:10.1136/gut.46.4.474 [Abstract] [Full text] [PDF] [Request Permissions]

Clostridium difficile toxin A excites enteric neurones and suppresses sympathetic neurotransmission in the guinea pig
Y Xia, H Z Hu, S Liu, C Pothoulakis, and J D Wood
Gut 2000; 46: 481-486. doi:10.1136/gut.46.4.481 [Abstract] [Full text] [PDF] [Request Permissions]

INFLAMMATION AND INFLAMMATORY BOWEL DISEASE

Measurement of in vivo rectal mucosal cytokine and eicosanoid production in ulcerative colitis using filter paper
E Carty, M De Brabander, R M Feakins, and D S Rampton
Gut 2000; 46: 487-492. doi:10.1136/gut.46.4.487 [Abstract] [Full text] [PDF] [Request Permissions]

Butyrate and glucose metabolism by colonocytes in experimental colitis in mice
M S Ahmad, S Krishnan, B S Ramakrishna, M Mathan, A B Pulimood, and S N Murthy
Gut 2000; 46: 493-499. doi:10.1136/gut.46.4.493 [Abstract] [Full text] [PDF] [Request Permissions]

A decision analysis of surveillance for colorectal cancer in ulcerative colitis
F Delcò and A Sonnenberg
Gut 2000; 46: 500-506. doi:10.1136/gut.46.4.500 [Abstract] [Full text] [PDF] [Request Permissions]

COLON

Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression
S Siavoshian, J-P Segain, M Kornprobst, C Bonnet, C Cherbut, J-P Galmiche, and H M Blottière
Gut 2000; 46: 507-514. doi:10.1136/gut.46.4.507 [Abstract] [Full text] [PDF] [Request Permissions]

Surface hydrophobicity of the rat colonic mucosa is a defensive barrier against macromolecules and toxins
A Lugea, A Salas, J Casalot, F Guarner, and J-R Malagelada
Gut 2000; 46: 515-521. doi:10.1136/gut.46.4.515 [Abstract] [Full text] [PDF] [Request Permissions]

Long term efficacy, safety, and tolerabilitity of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation
E Corazziari, D Badiali, G Bazzocchi, G Bassotti, P Roselli, G Mastropaolo, M G Lucà, R Galeazzi, and E Peruzzi
Gut 2000; 46: 522-526. doi:10.1136/gut.46.4.522 [Abstract] [Full text] [PDF] [Request Permissions]

LIVER DISEASE

Sodium handling in patients with well compensated cirrhosis is dependent on the severity of liver disease and portal pressure
R Jalan and P C Hayes
Gut 2000; 46: 527-533. doi:10.1136/gut.46.4.527 [Abstract] [Full text] [PDF] [Request Permissions]

Deficiency of natural anticoagulant proteins C, S, and antithrombin in portal vein thrombosis: a secondary phenomenon?
N C Fisher, J T Wilde, J Roper, and E Elias
Gut 2000; 46: 534-539. doi:10.1136/gut.46.4.534 [Abstract] [Full text] [PDF] [Request Permissions]

Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease
J Grove, A K Daly, M F Bassendine, E Gilvarry, and C P Day
Gut 2000; 46: 540-545. doi:10.1136/gut.46.4.540 [Abstract] [Full text] [PDF] [Request Permissions]

Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related cirrhosis
R Jalan, N Turjanski, S D Taylor-Robinson, M J Koepp, M P Richardson, J A Wilson, J D Bell, and D J Brooks
Gut 2000; 46: 546-552. doi:10.1136/gut.46.4.546 [Abstract] [Full text] [PDF] [Request Permissions]

Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane
L Muratori, M Parola, A Ripalti, G Robino, P Muratori, G Bellomo, R Carini, M Lenzi, M P Landini, E Albano, and F B Bianchi
Gut 2000; 46: 553-561. doi:10.1136/gut.46.4.553 [Abstract] [Full text] [PDF] [Request Permissions]

Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial
S W Schalm, J Heathcote, J Cianciara, G Farrell, M Sherman, B Willems, A Dhillon, A Moorat, J Barber, D F Gray, and International Lamivudine Study Group
Gut 2000; 46: 562-568. doi:10.1136/gut.46.4.562 [Abstract] [Full text] [PDF] [Request Permissions]

GALLSTONES

Gallstone disease in Peruvian coastal natives and highland migrants
P L Moro, W Checkley, R H Gilman, L Cabrera, A G Lescano, J J Bonilla, and B Silva
Gut 2000; 46: 569-573. doi:10.1136/gut.46.4.569 [Abstract] [Full text] [PDF] [Request Permissions]

CASE REPORTS

Intramucosal adenocarcinoma arising under squamous re-epithelialisation of Barrett's oesophagus
J L Van Laethem, M O Peny, I Salmon, M Cremer, and J Devière
Gut 2000; 46: 574-577. doi:10.1136/gut.46.4.574 [Abstract] [Full text] [PDF] [Request Permissions]

REVIEWS

TIPSS 10 years on
R JALAN, H F LUI, D N REDHEAD, and P C HAYES
Gut 2000; 46: 578-581. doi:10.1136/gut.46.4.578 [Extract] [Full text] [PDF] [Request Permissions]

LETTERS TO THE EDITOR

Towards immunotherapy for pancreatic cancer • Reply
B T BRETT, M E CAPLIN;, I F C MCKENZIE, and V APOSTOLOPOULOS
Gut 2000; 46: 582. doi:10.1136/gut.46.4.582 [Extract] [Full text] [PDF] [Request Permissions]

Ring-like elevations in the large bowel: endoscopic signs to distinguish the artefact from true neoplastic lesions • Reply
M MATSUSHITA, K HAJIRO, H TAKAKUWA, A NISHIO;, J P MARTIN, B P SAUNDERS, and J E PAINTER
Gut 2000; 46: 582. doi:10.1136/gut.46.4.582a [Extract] [Full text] [PDF] [Request Permissions]

Liver biopsy under ultrasound control: implications for training • Reply
S Y CHUAH;, S SHAH, J F MAYBERRY, A C B WICKS, Y REES, and R J PLAYFORD
Gut 2000; 46: 582. doi:10.1136/gut.46.4.582b [Extract] [Full text] [PDF] [Request Permissions]

BOOK REVIEWS

Vitamin D. Molecular Biology, Physiology and Clinical Applications.
J E COMPSTON
Gut 2000; 46: 582. doi:10.1136/gut.46.4.582c [Extract] [Full text] [PDF] [Request Permissions]

CORRECTIONS

Correction for vol. 45, p. 804
Gut 2000; 46: 582. [Extract] [Full text] [PDF] [Request Permissions]

Correction for vol. 44, p. 789
Gut 2000; 46: 582. [Extract] [Full text] [PDF] [Request Permissions]

Cover

Confocal microscope images of plasma membrane staining by liver/kidney microsomal antibody type 1 (LKM1) positive sera infreshly isolated rat hepatocytes, showing permeabilised hepatocytesprobed with the serum of a LKM1 positive subject (From the paperby Muratori et al, pp 553-61.)

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	Is liver fibrosis reversible? R C BENYON and J P IREDALE Gut 2000; 46: 443-446. doi:10.1136/gut.46.4.443 [Extract] [Full text] [PDF] [Request Permissions]

	The intracellular target of butyrate's actions: HDAC or HDON'T? P R GIBSON Gut 2000; 46: 447-448. doi:10.1136/gut.46.4.447 [Extract] [Full text] [PDF] [Request Permissions]

	Think cytokines before you drink S C L GOUGH Gut 2000; 46: 448-449. doi:10.1136/gut.46.4.448 [Extract] [Full text] [PDF] [Request Permissions]

	LKM antibody: getting in some target practice D VERGANI Gut 2000; 46: 449-450. doi:10.1136/gut.46.4.449 [Extract] [Full text] [PDF] [Request Permissions]

	Combination therapy of hepatitis B E DOO and J H HOOFNAGLE Gut 2000; 46: 450-451. doi:10.1136/gut.46.4.450 [Extract] [Full text] [PDF] [Request Permissions]

	Uteroglobin deficient mice $---$ a novel animal model for IgA nephropathy? S POURIA and S J CHALLACOMBE Gut 2000; 46: 452-453. doi:10.1136/gut.46.4.452 [Extract] [Full text] [PDF] [Request Permissions]

	The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach F E B May, J I Semple, J L Newton, and B R Westley Gut 2000; 46: 454-459. doi:10.1136/gut.46.4.454 [Abstract] [Full text] [PDF] [Request Permissions]

	*Atrophic gastritis and Helicobacter pylori* infection in outpatients referred for gastroscopy** A Oksanen, P Sipponen, R Karttunen, A Miettinen, L Veijola, S Sarna, and H Rautelin Gut 2000; 46: 460-463. doi:10.1136/gut.46.4.460 [Abstract] [Full text] [PDF] [Request Permissions]

	Detection of upper gastrointestinal cancer in patients taking antisecretory therapy prior to gastroscopy M G Bramble, Z Suvakovic, and A P S Hungin Gut 2000; 46: 464-467. doi:10.1136/gut.46.4.464 [Abstract] [Full text] [PDF] [Request Permissions]

	Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man J Tack, B Coulie, A Wilmer, A Andrioli, and J Janssens Gut 2000; 46: 468-473. doi:10.1136/gut.46.4.468 [Abstract] [Full text] [PDF] [Request Permissions]

	*The 5-HT₃ receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos* expression in the anaesthetised rat** C M Kozlowski, A Green, D Grundy, F M Boissonade, and C Bountra Gut 2000; 46: 474-480. doi:10.1136/gut.46.4.474 [Abstract] [Full text] [PDF] [Request Permissions]

	Clostridium difficile toxin A excites enteric neurones and suppresses sympathetic neurotransmission in the guinea pig Y Xia, H Z Hu, S Liu, C Pothoulakis, and J D Wood Gut 2000; 46: 481-486. doi:10.1136/gut.46.4.481 [Abstract] [Full text] [PDF] [Request Permissions]

	Measurement of in vivo rectal mucosal cytokine and eicosanoid production in ulcerative colitis using filter paper E Carty, M De Brabander, R M Feakins, and D S Rampton Gut 2000; 46: 487-492. doi:10.1136/gut.46.4.487 [Abstract] [Full text] [PDF] [Request Permissions]

	Butyrate and glucose metabolism by colonocytes in experimental colitis in mice M S Ahmad, S Krishnan, B S Ramakrishna, M Mathan, A B Pulimood, and S N Murthy Gut 2000; 46: 493-499. doi:10.1136/gut.46.4.493 [Abstract] [Full text] [PDF] [Request Permissions]

	A decision analysis of surveillance for colorectal cancer in ulcerative colitis F Delcò and A Sonnenberg Gut 2000; 46: 500-506. doi:10.1136/gut.46.4.500 [Abstract] [Full text] [PDF] [Request Permissions]

	Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression S Siavoshian, J-P Segain, M Kornprobst, C Bonnet, C Cherbut, J-P Galmiche, and H M Blottière Gut 2000; 46: 507-514. doi:10.1136/gut.46.4.507 [Abstract] [Full text] [PDF] [Request Permissions]

	Surface hydrophobicity of the rat colonic mucosa is a defensive barrier against macromolecules and toxins A Lugea, A Salas, J Casalot, F Guarner, and J-R Malagelada Gut 2000; 46: 515-521. doi:10.1136/gut.46.4.515 [Abstract] [Full text] [PDF] [Request Permissions]

	Long term efficacy, safety, and tolerabilitity of low daily doses of isosmotic polyethylene glycol electrolyte balanced solution (PMF-100) in the treatment of functional chronic constipation E Corazziari, D Badiali, G Bazzocchi, G Bassotti, P Roselli, G Mastropaolo, M G Lucà, R Galeazzi, and E Peruzzi Gut 2000; 46: 522-526. doi:10.1136/gut.46.4.522 [Abstract] [Full text] [PDF] [Request Permissions]

	Sodium handling in patients with well compensated cirrhosis is dependent on the severity of liver disease and portal pressure R Jalan and P C Hayes Gut 2000; 46: 527-533. doi:10.1136/gut.46.4.527 [Abstract] [Full text] [PDF] [Request Permissions]

	Deficiency of natural anticoagulant proteins C, S, and antithrombin in portal vein thrombosis: a secondary phenomenon? N C Fisher, J T Wilde, J Roper, and E Elias Gut 2000; 46: 534-539. doi:10.1136/gut.46.4.534 [Abstract] [Full text] [PDF] [Request Permissions]

	Interleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease J Grove, A K Daly, M F Bassendine, E Gilvarry, and C P Day Gut 2000; 46: 540-545. doi:10.1136/gut.46.4.540 [Abstract] [Full text] [PDF] [Request Permissions]

	Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related cirrhosis R Jalan, N Turjanski, S D Taylor-Robinson, M J Koepp, M P Richardson, J A Wilson, J D Bell, and D J Brooks Gut 2000; 46: 546-552. doi:10.1136/gut.46.4.546 [Abstract] [Full text] [PDF] [Request Permissions]

	Liver/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane L Muratori, M Parola, A Ripalti, G Robino, P Muratori, G Bellomo, R Carini, M Lenzi, M P Landini, E Albano, and F B Bianchi Gut 2000; 46: 553-561. doi:10.1136/gut.46.4.553 [Abstract] [Full text] [PDF] [Request Permissions]

	Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial S W Schalm, J Heathcote, J Cianciara, G Farrell, M Sherman, B Willems, A Dhillon, A Moorat, J Barber, D F Gray, and International Lamivudine Study Group Gut 2000; 46: 562-568. doi:10.1136/gut.46.4.562 [Abstract] [Full text] [PDF] [Request Permissions]

	Gallstone disease in Peruvian coastal natives and highland migrants P L Moro, W Checkley, R H Gilman, L Cabrera, A G Lescano, J J Bonilla, and B Silva Gut 2000; 46: 569-573. doi:10.1136/gut.46.4.569 [Abstract] [Full text] [PDF] [Request Permissions]

	Intramucosal adenocarcinoma arising under squamous re-epithelialisation of Barrett's oesophagus J L Van Laethem, M O Peny, I Salmon, M Cremer, and J Devière Gut 2000; 46: 574-577. doi:10.1136/gut.46.4.574 [Abstract] [Full text] [PDF] [Request Permissions]

	TIPSS 10 years on R JALAN, H F LUI, D N REDHEAD, and P C HAYES Gut 2000; 46: 578-581. doi:10.1136/gut.46.4.578 [Extract] [Full text] [PDF] [Request Permissions]

	Towards immunotherapy for pancreatic cancer • Reply B T BRETT, M E CAPLIN;, I F C MCKENZIE, and V APOSTOLOPOULOS Gut 2000; 46: 582. doi:10.1136/gut.46.4.582 [Extract] [Full text] [PDF] [Request Permissions]

	Ring-like elevations in the large bowel: endoscopic signs to distinguish the artefact from true neoplastic lesions • Reply M MATSUSHITA, K HAJIRO, H TAKAKUWA, A NISHIO;, J P MARTIN, B P SAUNDERS, and J E PAINTER Gut 2000; 46: 582. doi:10.1136/gut.46.4.582a [Extract] [Full text] [PDF] [Request Permissions]

	Liver biopsy under ultrasound control: implications for training • Reply S Y CHUAH;, S SHAH, J F MAYBERRY, A C B WICKS, Y REES, and R J PLAYFORD Gut 2000; 46: 582. doi:10.1136/gut.46.4.582b [Extract] [Full text] [PDF] [Request Permissions]

	Vitamin D. Molecular Biology, Physiology and Clinical Applications. J E COMPSTON Gut 2000; 46: 582. doi:10.1136/gut.46.4.582c [Extract] [Full text] [PDF] [Request Permissions]

	Correction for vol. 45, p. 804 Gut 2000; 46: 582. [Extract] [Full text] [PDF] [Request Permissions]

	Correction for vol. 44, p. 789 Gut 2000; 46: 582. [Extract] [Full text] [PDF] [Request Permissions]