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May 2000 (Volume 46, Number 5). [Index by author]

	(Cover illustration)	LEADING ARTICLES COMMENTARIES SCIENCE ALERTS OESOPHAGUS STOMACH METAPLASIA AND NEOPLASIA FOOD ALLERGY INFLAMMATORY BOWEL DISEASE NUTRITION LIVER AND BILIARY DISEASE CASE REPORTS OCCASIONAL VIEWPOINT LETTERS TO THE EDITOR BOOK REVIEWS

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LEADING ARTICLES

The molecular and genetic base of congenital transport defects
J-F DESJEUX
Gut 2000; 46: 585-587. doi:10.1136/gut.46.5.585 [Extract] [Full text] [PDF] [Request Permissions]

Is there still a need for albumin infusions to treat patients with liver disease?
P GINÈS and V ARROYO
Gut 2000; 46: 588-590. doi:10.1136/gut.46.5.588 [Extract] [Full text] [PDF] [Request Permissions]

COMMENTARIES

GLP-1 and the gut
D G THOMPSON
Gut 2000; 46: 591. doi:10.1136/gut.46.5.591 [Extract] [Full text] [PDF] [Request Permissions]

Why treat chronic hepatitis B in childhood with interferon $alpha$ ?
E A ROBERTS
Gut 2000; 46: 591-593. doi:10.1136/gut.46.5.591a [Extract] [Full text] [PDF] [Request Permissions]

Hepatic regeneration and TGF- $beta$ : growing to a prosperous perfection
E WILLIAMS and J IREDALE
Gut 2000; 46: 593-594. doi:10.1136/gut.46.5.593 [Extract] [Full text] [PDF] [Request Permissions]

SCIENCE ALERTS

Psychological stress and colitis
E A MAYER
Gut 2000; 46: 595-596. doi:10.1136/gut.46.5.595 [Extract] [Full text] [PDF] [Request Permissions]

OESOPHAGUS

A multicentre randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia
V Annese, G Bassotti, G Coccia, M Dinelli, V D'Onofrio, G Gatto, G Leandro, A Repici, P A Testoni, A Andriulli, and the GISMAD Achalasia Study Group
Gut 2000; 46: 597-600. doi:10.1136/gut.46.5.597 [Abstract] [Full text] [PDF] [Request Permissions]

STOMACH

H pylori colocalises with MUC5AC in the human stomach
G R Van den Brink, K M A J Tytgat, R W M Van der Hulst, C M Van der Loos, A W C Einerhand, H A Büller, and J Dekker
Gut 2000; 46: 601-607. doi:10.1136/gut.46.5.601 [Abstract] [Full text] [PDF] [Request Permissions]

Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation
K Trebesius, K Panthel, S Strobel, K Vogt, G Faller, T Kirchner, M Kist, J Heesemann, and R Haas
Gut 2000; 46: 608-614. doi:10.1136/gut.46.5.608 [Abstract] [Full text] [PDF] [Request Permissions]

Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy
B E Schenk, E J Kuipers, G F Nelis, E Bloemena, J C Thijs, P Snel, A E G Luckers, E C Klinkenberg-Knol, H P M Festen, P P Viergever, J Lindeman, and S G M Meuwissen
Gut 2000; 46: 615-621. doi:10.1136/gut.46.5.615 [Abstract] [Full text] [PDF] [Request Permissions]

Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans
J Schirra, P Houck, U Wank, R Arnold, B Göke, and M Katschinski
Gut 2000; 46: 622-631. doi:10.1136/gut.46.5.622 [Abstract] [Full text] [PDF] [Request Permissions]

METAPLASIA AND NEOPLASIA

The pathogenesis of duodenal gastric metaplasia: the role of local goblet cell transformation
R Shaoul, P Marcon, Y Okada, E Cutz, and G Forstner
Gut 2000; 46: 632-638. doi:10.1136/gut.46.5.632 [Abstract] [Full text] [PDF] [Request Permissions]

$alpha$ -Catenin expression is decreased in human gastric cancers and in the gastric mucosa of first degree relatives
J Yu, M P A Ebert, S Miehlke, H Rost, U Lendeckel, A Leodolter, M Stolte, E Bayerdörffer, and P Malfertheiner
Gut 2000; 46: 639-644. doi:10.1136/gut.46.5.639 [Abstract] [Full text] [PDF] [Request Permissions]

Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma
A I Sarela, R C A Macadam, S M Farmery, A F Markham, and P J Guillou
Gut 2000; 46: 645-650. doi:10.1136/gut.46.5.645 [Abstract] [Full text] [PDF] [Request Permissions]

Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study
G Nusko, B Schneider, I Schneider, Ch Wittekind, and E G Hahn
Gut 2000; 46: 651-655. doi:10.1136/gut.46.5.651 [Abstract] [Full text] [PDF] [Request Permissions]

Analysis of genetic and phenotypic heterogeneity in juvenile polyposis
K Woodford-Richens, S Bevan, M Churchman, B Dowling, D Jones, C G Norbury, S V Hodgson, D Desai, K Neale, R K S Phillips, J Young, B Leggett, M Dunlop, P Rozen, C Eng, D Markie, M A Rodriguez-Bigas, E Sheridan, T Iwama, D Eccles, G T Smith, J C Kim, K M Kim, J R Sampson, G Evans, S Tejpar, W F Bodmer, I P M Tomlinson, and R S Houlston
Gut 2000; 46: 656-660. doi:10.1136/gut.46.5.656 [Abstract] [Full text] [PDF] [Request Permissions]

FOOD ALLERGY

Purification, biochemical, and immunological characterisation of a major food allergen: different immunoglobulin E recognition of the apo- and calcium-bound forms of carp parvalbumin
A Bugajska-Schretter, M Grote, L Vangelista, P Valent, W R Sperr, H Rumpold, A Pastore, R Reichelt, R Valenta, and S Spitzauer
Gut 2000; 46: 661-669. doi:10.1136/gut.46.5.661 [Abstract] [Full text] [PDF] [Request Permissions]

INFLAMMATORY BOWEL DISEASE

Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease
F F di Mola, H Friess, Z W Zhu, A Koliopanos, T Bley, P Di Sebastiano, P Innocenti, A Zimmermann, and M W Büchler
Gut 2000; 46: 670-679. doi:10.1136/gut.46.5.670 [Abstract] [Full text] [PDF] [Request Permissions]

NUTRITION

Decreased levels of heat shock proteins in gut epithelial cells after exposure to plant lectins
J H Ovelgönne, J F J G Koninkx, A Pusztai, S Bardocz, W Kok, S W B Ewen, H G C J M Hendriks, and J E van Dijk
Gut 2000; 46: 680-688. doi:10.1136/gut.46.5.680 [Abstract] [Full text] [PDF] [Request Permissions]

The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans
D Matzinger, L Degen, J Drewe, J Meuli, R Duebendorfer, N Ruckstuhl, M D'Amato, L Rovati, and C Beglinger
Gut 2000; 46: 689-694. doi:10.1136/gut.46.5.689 [Abstract] [Full text] [PDF] [Request Permissions]

Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis
A B Ballinger, O Azooz, T El-Haj, S Poole, and M J G Farthing
Gut 2000; 46: 695-700. doi:10.1136/gut.46.5.695 [Abstract] [Full text] [PDF] [Request Permissions]

Intestinal failure defined by measurements of intestinal energy and wet weight absorption
P B Jeppesen and P B Mortensen
Gut 2000; 46: 701-706. doi:10.1136/gut.46.5.701 [Abstract] [Full text] [PDF] [Request Permissions]

LIVER AND BILIARY DISEASE

Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase
M Bhavnani, D Lloyd, A Bhattacharyya, J Marples, P Elton, and M Worwood
Gut 2000; 46: 707-710. doi:10.1136/gut.46.5.707 [Abstract] [Full text] [PDF] [Request Permissions]

Liver iron excess in patients with hepatocellular carcinoma developed on viral C cirrhosis
C Chapoutot, M Esslimani, Z Joomaye, J Ramos, P Perney, C Laurent, P Fabbro-Peray, D Larrey, J Domergue, and F Blanc
Gut 2000; 46: 711-714. doi:10.1136/gut.46.5.711 [Abstract] [Full text] [PDF] [Request Permissions]

Long term effect of alpha interferon in children with chronic hepatitis B
F Bortolotti, P Jara, C Barbera, G V Gregorio, A Vegnente, L Zancan, L Hierro, C Crivellaro, G Mieli Vergani, R Iorio, M Pace, P Con, and A Gatta
Gut 2000; 46: 715-718. doi:10.1136/gut.46.5.715 [Abstract] [Full text] [PDF] [Request Permissions]

Modulation of transforming growth factor $beta$ function in hepatocytes and hepatic stellate cells in rat liver injury
M Date, K Matsuzaki, M Matsushita, Y Tahashi, F Furukawa, and K Inoue
Gut 2000; 46: 719-724. doi:10.1136/gut.46.5.719 [Abstract] [Full text] [PDF] [Request Permissions]

Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage
A N Kimmings, S J H van Deventer, H Obertop, E A J Rauws, K Huibregtse, and D J Gouma
Gut 2000; 46: 725-731. doi:10.1136/gut.46.5.725 [Abstract] [Full text] [PDF] [Request Permissions]

CASE REPORTS

Sporadic acute hepatitis E in the United Kingdom: an underdiagnosed phenomenon?
R McCrudden, S O'Connell, T Farrant, S Beaton, J P Iredale, and D Fine
Gut 2000; 46: 732-733. doi:10.1136/gut.46.5.732 [Abstract] [Full text] [PDF] [Request Permissions]

OCCASIONAL VIEWPOINT

Coeliac disease: it takes three to tango!
Y VAN DE WAL, Y KOOY, P VAN VEELEN, W VADER, F KONING, and S PEÑA
Gut 2000; 46: 734-737. doi:10.1136/gut.46.5.734 [Extract] [Full text] [PDF] [Request Permissions]

LETTERS TO THE EDITOR

Gastric cancer cell lines lack Fas ligand (FasL) expression but kill T cells via a FasL independent pathway • Reply
I TINHOFER, H WYKYPIEL, I MARSCHITZ, T HENN, R GREIL;, M W BENNETT, J O'CONNELL, D ROCHE, C BRADY, J KELLY, J K COLLINS, F SHANAHAN, and G C O'SULLIVAN
Gut 2000; 46: 738-740. doi:10.1136/gut.46.5.738 [Extract] [Full text] [PDF] [Request Permissions]

Vector manometry and LOS dynamics
AD JENKINSON, SM SCOTT, and SS KADIRKAMANATHAN
Gut 2000; 46: 740. doi:10.1136/gut.46.5.740 [Extract] [Full text] [PDF] [Request Permissions]

Mycophenolate mofetil for Crohn's disease • Reply
J C ATHERTON; and M NEURATH
Gut 2000; 46: 740-741. doi:10.1136/gut.46.5.740a [Extract] [Full text] [PDF] [Request Permissions]

BOOK REVIEWS

Emergency Abdominal Surgery.
M R B KEIGHLEY
Gut 2000; 46: 741. doi:10.1136/gut.46.5.741 [Extract] [Full text] [PDF] [Request Permissions]

Gastroenterology. 2nd edition.
R A HARRY
Gut 2000; 46: 741. doi:10.1136/gut.46.5.741a [Extract] [Full text] [PDF] [Request Permissions]

Rome II: the Functional Gastrointestinal Disorders. Diagnosis, Pathophysiology and Treatment: a Multinational Consensus
ROBIN SPILLER
Gut 2000; 46: 741. doi:10.1136/gut.46.5.741b [Extract] [Full text] [PDF] [Request Permissions]

Cover

Phase contrast microscopy of a mixture of clarithromycin sensitive and resistant H pylori isolates following hybridisationwith probes ClaWT-FLUOS (green) and ClaR1-Cy3 (red). (From thepaper by Trebesius et al, pp 608-14.)

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	The molecular and genetic base of congenital transport defects J-F DESJEUX Gut 2000; 46: 585-587. doi:10.1136/gut.46.5.585 [Extract] [Full text] [PDF] [Request Permissions]

	Is there still a need for albumin infusions to treat patients with liver disease? P GINÈS and V ARROYO Gut 2000; 46: 588-590. doi:10.1136/gut.46.5.588 [Extract] [Full text] [PDF] [Request Permissions]

	GLP-1 and the gut D G THOMPSON Gut 2000; 46: 591. doi:10.1136/gut.46.5.591 [Extract] [Full text] [PDF] [Request Permissions]

	Why treat chronic hepatitis B in childhood with interferon $alpha$ ? E A ROBERTS Gut 2000; 46: 591-593. doi:10.1136/gut.46.5.591a [Extract] [Full text] [PDF] [Request Permissions]

	Hepatic regeneration and TGF- $beta$ : growing to a prosperous perfection E WILLIAMS and J IREDALE Gut 2000; 46: 593-594. doi:10.1136/gut.46.5.593 [Extract] [Full text] [PDF] [Request Permissions]

	Psychological stress and colitis E A MAYER Gut 2000; 46: 595-596. doi:10.1136/gut.46.5.595 [Extract] [Full text] [PDF] [Request Permissions]

	A multicentre randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia V Annese, G Bassotti, G Coccia, M Dinelli, V D'Onofrio, G Gatto, G Leandro, A Repici, P A Testoni, A Andriulli, and the GISMAD Achalasia Study Group Gut 2000; 46: 597-600. doi:10.1136/gut.46.5.597 [Abstract] [Full text] [PDF] [Request Permissions]

	H pylori colocalises with MUC5AC in the human stomach G R Van den Brink, K M A J Tytgat, R W M Van der Hulst, C M Van der Loos, A W C Einerhand, H A Büller, and J Dekker Gut 2000; 46: 601-607. doi:10.1136/gut.46.5.601 [Abstract] [Full text] [PDF] [Request Permissions]

	*Rapid and specific detection of Helicobacter pylori* macrolide resistance in gastric tissue by fluorescent in situ hybridisation** K Trebesius, K Panthel, S Strobel, K Vogt, G Faller, T Kirchner, M Kist, J Heesemann, and R Haas Gut 2000; 46: 608-614. doi:10.1136/gut.46.5.608 [Abstract] [Full text] [PDF] [Request Permissions]

	*Effect of Helicobacter pylori* eradication on chronic gastritis during omeprazole therapy** B E Schenk, E J Kuipers, G F Nelis, E Bloemena, J C Thijs, P Snel, A E G Luckers, E C Klinkenberg-Knol, H P M Festen, P P Viergever, J Lindeman, and S G M Meuwissen Gut 2000; 46: 615-621. doi:10.1136/gut.46.5.615 [Abstract] [Full text] [PDF] [Request Permissions]

	Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans J Schirra, P Houck, U Wank, R Arnold, B Göke, and M Katschinski Gut 2000; 46: 622-631. doi:10.1136/gut.46.5.622 [Abstract] [Full text] [PDF] [Request Permissions]

	The pathogenesis of duodenal gastric metaplasia: the role of local goblet cell transformation R Shaoul, P Marcon, Y Okada, E Cutz, and G Forstner Gut 2000; 46: 632-638. doi:10.1136/gut.46.5.632 [Abstract] [Full text] [PDF] [Request Permissions]

	$alpha$ -Catenin expression is decreased in human gastric cancers and in the gastric mucosa of first degree relatives J Yu, M P A Ebert, S Miehlke, H Rost, U Lendeckel, A Leodolter, M Stolte, E Bayerdörffer, and P Malfertheiner Gut 2000; 46: 639-644. doi:10.1136/gut.46.5.639 [Abstract] [Full text] [PDF] [Request Permissions]

	*Expression of the antiapoptosis gene, Survivin, predicts death from recurrent colorectal carcinoma* A I Sarela, R C A Macadam, S M Farmery, A F Markham, and P J Guillou Gut 2000; 46: 645-650. doi:10.1136/gut.46.5.645 [Abstract] [Full text] [PDF] [Request Permissions]

	Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study G Nusko, B Schneider, I Schneider, Ch Wittekind, and E G Hahn Gut 2000; 46: 651-655. doi:10.1136/gut.46.5.651 [Abstract] [Full text] [PDF] [Request Permissions]

	Analysis of genetic and phenotypic heterogeneity in juvenile polyposis K Woodford-Richens, S Bevan, M Churchman, B Dowling, D Jones, C G Norbury, S V Hodgson, D Desai, K Neale, R K S Phillips, J Young, B Leggett, M Dunlop, P Rozen, C Eng, D Markie, M A Rodriguez-Bigas, E Sheridan, T Iwama, D Eccles, G T Smith, J C Kim, K M Kim, J R Sampson, G Evans, S Tejpar, W F Bodmer, I P M Tomlinson, and R S Houlston Gut 2000; 46: 656-660. doi:10.1136/gut.46.5.656 [Abstract] [Full text] [PDF] [Request Permissions]

	Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease F F di Mola, H Friess, Z W Zhu, A Koliopanos, T Bley, P Di Sebastiano, P Innocenti, A Zimmermann, and M W Büchler Gut 2000; 46: 670-679. doi:10.1136/gut.46.5.670 [Abstract] [Full text] [PDF] [Request Permissions]

	Decreased levels of heat shock proteins in gut epithelial cells after exposure to plant lectins J H Ovelgönne, J F J G Koninkx, A Pusztai, S Bardocz, W Kok, S W B Ewen, H G C J M Hendriks, and J E van Dijk Gut 2000; 46: 680-688. doi:10.1136/gut.46.5.680 [Abstract] [Full text] [PDF] [Request Permissions]

	The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans D Matzinger, L Degen, J Drewe, J Meuli, R Duebendorfer, N Ruckstuhl, M D'Amato, L Rovati, and C Beglinger Gut 2000; 46: 689-694. doi:10.1136/gut.46.5.689 [Abstract] [Full text] [PDF] [Request Permissions]

	Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis A B Ballinger, O Azooz, T El-Haj, S Poole, and M J G Farthing Gut 2000; 46: 695-700. doi:10.1136/gut.46.5.695 [Abstract] [Full text] [PDF] [Request Permissions]

	Intestinal failure defined by measurements of intestinal energy and wet weight absorption P B Jeppesen and P B Mortensen Gut 2000; 46: 701-706. doi:10.1136/gut.46.5.701 [Abstract] [Full text] [PDF] [Request Permissions]

	Screening for genetic haemochromatosis in blood samples with raised alanine aminotransferase M Bhavnani, D Lloyd, A Bhattacharyya, J Marples, P Elton, and M Worwood Gut 2000; 46: 707-710. doi:10.1136/gut.46.5.707 [Abstract] [Full text] [PDF] [Request Permissions]

	Liver iron excess in patients with hepatocellular carcinoma developed on viral C cirrhosis C Chapoutot, M Esslimani, Z Joomaye, J Ramos, P Perney, C Laurent, P Fabbro-Peray, D Larrey, J Domergue, and F Blanc Gut 2000; 46: 711-714. doi:10.1136/gut.46.5.711 [Abstract] [Full text] [PDF] [Request Permissions]

	Long term effect of alpha interferon in children with chronic hepatitis B F Bortolotti, P Jara, C Barbera, G V Gregorio, A Vegnente, L Zancan, L Hierro, C Crivellaro, G Mieli Vergani, R Iorio, M Pace, P Con, and A Gatta Gut 2000; 46: 715-718. doi:10.1136/gut.46.5.715 [Abstract] [Full text] [PDF] [Request Permissions]

	Modulation of transforming growth factor $beta$ function in hepatocytes and hepatic stellate cells in rat liver injury M Date, K Matsuzaki, M Matsushita, Y Tahashi, F Furukawa, and K Inoue Gut 2000; 46: 719-724. doi:10.1136/gut.46.5.719 [Abstract] [Full text] [PDF] [Request Permissions]

	Endotoxin, cytokines, and endotoxin binding proteins in obstructive jaundice and after preoperative biliary drainage A N Kimmings, S J H van Deventer, H Obertop, E A J Rauws, K Huibregtse, and D J Gouma Gut 2000; 46: 725-731. doi:10.1136/gut.46.5.725 [Abstract] [Full text] [PDF] [Request Permissions]

	Sporadic acute hepatitis E in the United Kingdom: an underdiagnosed phenomenon? R McCrudden, S O'Connell, T Farrant, S Beaton, J P Iredale, and D Fine Gut 2000; 46: 732-733. doi:10.1136/gut.46.5.732 [Abstract] [Full text] [PDF] [Request Permissions]

	Coeliac disease: it takes three to tango! Y VAN DE WAL, Y KOOY, P VAN VEELEN, W VADER, F KONING, and S PEÑA Gut 2000; 46: 734-737. doi:10.1136/gut.46.5.734 [Extract] [Full text] [PDF] [Request Permissions]

	Gastric cancer cell lines lack Fas ligand (FasL) expression but kill T cells via a FasL independent pathway • Reply I TINHOFER, H WYKYPIEL, I MARSCHITZ, T HENN, R GREIL;, M W BENNETT, J O'CONNELL, D ROCHE, C BRADY, J KELLY, J K COLLINS, F SHANAHAN, and G C O'SULLIVAN Gut 2000; 46: 738-740. doi:10.1136/gut.46.5.738 [Extract] [Full text] [PDF] [Request Permissions]

	Vector manometry and LOS dynamics AD JENKINSON, SM SCOTT, and SS KADIRKAMANATHAN Gut 2000; 46: 740. doi:10.1136/gut.46.5.740 [Extract] [Full text] [PDF] [Request Permissions]

	Mycophenolate mofetil for Crohn's disease • Reply J C ATHERTON; and M NEURATH Gut 2000; 46: 740-741. doi:10.1136/gut.46.5.740a [Extract] [Full text] [PDF] [Request Permissions]

	Emergency Abdominal Surgery. M R B KEIGHLEY Gut 2000; 46: 741. doi:10.1136/gut.46.5.741 [Extract] [Full text] [PDF] [Request Permissions]

	Gastroenterology. 2nd edition. R A HARRY Gut 2000; 46: 741. doi:10.1136/gut.46.5.741a [Extract] [Full text] [PDF] [Request Permissions]

	Rome II: the Functional Gastrointestinal Disorders. Diagnosis, Pathophysiology and Treatment: a Multinational Consensus ROBIN SPILLER Gut 2000; 46: 741. doi:10.1136/gut.46.5.741b [Extract] [Full text] [PDF] [Request Permissions]