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June 2000 (Volume 46, Number 6). [Index by author]

	(Cover illustration)	ABSTRACTS FROM A CONFERENCE LEADING ARTICLES POSITION STATEMENT COMMENTARIES SCIENCE ALERTS CLINICAL ALERTS OESOPHAGUS STOMACH CANCER ENDOSCOPY INFECTION NUTRITION CELL BIOLOGY BILIARY TRACT LIVER DISEASE REVIEWS OCCASIONAL VIEWPOINT LETTERS TO THE EDITOR

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ABSTRACTS FROM A CONFERENCE

British Association for the Study of the Liver Meeting
Gut 2000; 46: 1. doi:10.1136/gut.46.6.e1 [PDF] [Request Permissions]

LEADING ARTICLES

Hepatic stem cells
A J STRAIN and H A CROSBY
Gut 2000; 46: 743-745. doi:10.1136/gut.46.6.743 [Extract] [Full text] [PDF] [Request Permissions]

POSITION STATEMENT

Colorectal cancer screening in the UK: Joint Position Statement by the British Society of Gastroenterology, the Royal College of Physicians, and the Association of Coloproctology of Great Britain and Ireland
JM RHODES
Gut 2000; 46: 746-748. doi:10.1136/gut.46.6.746 [Extract] [Full text] [PDF] [Request Permissions]

COMMENTARIES

Perioperative nutritional support: does it reduce hospital complications or shorten convalescence?
J POWELL-TUCK
Gut 2000; 46: 749-750. doi:10.1136/gut.46.6.749 [Extract] [Full text] [PDF] [Request Permissions]

Morphine and biliary pain revisited
E A SHAFFER
Gut 2000; 46: 750-751. doi:10.1136/gut.46.6.750 [Extract] [Full text] [PDF] [Request Permissions]

SCIENCE ALERTS

Innate immunity to carcinomas?
S J C GOLBY and J SPENCER
Gut 2000; 46: 752-753. doi:10.1136/gut.46.6.752 [Extract] [Full text] [PDF] [Request Permissions]

CLINICAL ALERTS

Symptomatic gastro-oesophageal reflux as a risk factor for oesophageal adenocarcinoma
A J CAMERON and Y ROMERO
Gut 2000; 46: 754-755. doi:10.1136/gut.46.6.754 [Extract] [Full text] [PDF] [Request Permissions]

OESOPHAGUS

Neuromuscular function of the human lower oesophageal sphincter in reflux disease and Barrett's oesophagus
S D Smid and L A Blackshaw
Gut 2000; 46: 756-761. doi:10.1136/gut.46.6.756 [Abstract] [Full text] [PDF] [Request Permissions]

Cough threshold in reflux oesophagitis: influence of acid and of laryngeal and oesophageal damage
L Benini, M Ferrari, C Sembenini, M Olivieri, R Micciolo, V Zuccali, G M Bulighin, F Fiorino, A Ederle, V Lo Cascio, and I Vantini
Gut 2000; 46: 762-767. doi:10.1136/gut.46.6.762 [Abstract] [Full text] [PDF] [Request Permissions]

STOMACH

A valid, accurate, office based non-radioactive test for gastric emptying of solids
J S Lee, M Camilleri, A R Zinsmeister, D D Burton, L J Kost, and P D Klein
Gut 2000; 46: 768-773. doi:10.1136/gut.46.6.768 [Abstract] [Full text] [PDF] [Request Permissions]

Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor
J Borovicka, W Schwizer, G Guttmann, D Hartmann, M Kosinski, C Wastiel, A Bischof-Delaloye, and M Fried
Gut 2000; 46: 774-781. doi:10.1136/gut.46.6.774 [Abstract] [Full text] [PDF] [Request Permissions]

Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans
A Tatsuguchi, C Sakamoto, K Wada, T Akamatsu, T Tsukui, K Miyake, S Futagami, T Kishida, Y Fukuda, N Yamanaka, and M Kobayashi
Gut 2000; 46: 782-789. doi:10.1136/gut.46.6.782 [Abstract] [Full text] [PDF] [Request Permissions]

CANCER

Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract
K Yamashita, Y Arimura, S Kurokawa, F Itoh, T Endo, K Hirata, A Imamura, M Kondo, T Sato, and K Imai
Gut 2000; 46: 790-794. doi:10.1136/gut.46.6.790 [Abstract] [Full text] [PDF] [Request Permissions]

Faecal calprotectin levels in a high risk population for colorectal neoplasia
O Kronborg, M Ugstad, P Fuglerud, B Johne, J Hardcastle, J H Scholefield, K Vellacott, V Moshakis, and J R Reynolds
Gut 2000; 46: 795-800. doi:10.1136/gut.46.6.795 [Abstract] [Full text] [PDF] [Request Permissions]

ENDOSCOPY

A new variable stiffness colonoscope makes colonoscopy easier: a randomised controlled trial
J C Brooker, B P Saunders, S G Shah, and C B Williams
Gut 2000; 46: 801-805. doi:10.1136/gut.46.6.801 [Abstract] [Full text] [PDF] [Request Permissions]

INFECTION

Do eicosanoids cause colonic dysfunction in experimental E coli 0157:H7 (EHEC) infection?
C J Bell, E J Elliott, J L Wallace, D M Redmond, J Payne, Z Li, and E V O'Loughlin
Gut 2000; 46: 806-812. doi:10.1136/gut.46.6.806 [Abstract] [Full text] [PDF] [Request Permissions]

NUTRITION

A randomised controlled trial evaluating the use of enteral nutritional supplements postoperatively in malnourished surgical patients
A H Beattie, A T Prach, J P Baxter, and C R Pennington
Gut 2000; 46: 813-818. doi:10.1136/gut.46.6.813 [Abstract] [Full text] [PDF] [Request Permissions]

Absorption of calcium and magnesium in patients with intestinal resections treated with medium chain fatty acids
K V Haderslev, P B Jeppesen, P B Mortensen, and M Staun
Gut 2000; 46: 819-823. doi:10.1136/gut.46.6.819 [Abstract] [Full text] [PDF] [Request Permissions]

Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: a study of a concept
S Björck, I Bosaeus, E Ek, E Jennische, I Lönnroth, E Johansson, and S Lange
Gut 2000; 46: 824-829. doi:10.1136/gut.46.6.824 [Abstract] [Full text] [PDF] [Request Permissions]

CELL BIOLOGY

Carbonylation and disassembly of the F-actin cytoskeleton in oxidant induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor $alpha$ in a human colonic cell line
A Banan, Y Zhang, J Losurdo, and A Keshavarzian
Gut 2000; 46: 830-837. doi:10.1136/gut.46.6.830 [Abstract] [Full text] [PDF] [Request Permissions]

BILIARY TRACT

Use of ^99mTc-DISIDA biliary scanning with morphine provocation for the detection of elevated sphincter of Oddi basal pressure
P D Thomas, J G Turner, B R Dobbs, M J Burt, and B A Chapman
Gut 2000; 46: 838-841. doi:10.1136/gut.46.6.838 [Abstract] [Full text] [PDF] [Request Permissions]

Cancer of the ampulla of Vater: chromosome 17p allelic loss is associated with poor prognosis
A Scarpa, C Di Pace, G Talamini, M Falconi, N R Lemoine, C Iacono, A Achille, A Baron, and G Zamboni
Gut 2000; 46: 842-848. doi:10.1136/gut.46.6.842 [Abstract] [Full text] [PDF] [Request Permissions]

LIVER DISEASE

Post-feeding hyperammonaemia in patients with transjugular intrahepatic portosystemic shunt and liver cirrhosis: role of small intestinal ammonia release and route of nutrient administration
M Plauth, A-E Roske, P Romaniuk, E Roth, R Ziebig, and H Lochs
Gut 2000; 46: 849-855. doi:10.1136/gut.46.6.849 [Abstract] [Full text] [PDF] [Request Permissions]

CO₂ wedged hepatic venography in the evaluation of portal hypertension
W Debernardi-Venon, J-C Bandi, J-C García-Pagán, E Moitinho, V Andreu, M Real, A Escorsell, X Montanyá, and J Bosch
Gut 2000; 46: 856-860. doi:10.1136/gut.46.6.856 [Abstract] [Full text] [PDF] [Request Permissions]

REVIEWS

Neuromyogenic properties of the internal anal sphincter: therapeutic rationale for anal fissures
R BHARDWAJ, C J VAIZEY, P B BOULOS, and C H V HOYLE
Gut 2000; 46: 861-868. doi:10.1136/gut.46.6.861 [Extract] [Full text] [PDF] [Request Permissions]

OCCASIONAL VIEWPOINT

Stem cell transplantation for inflammatory bowel disease: practical and ethical issues
C J HAWKEY, J A SNOWDEN, A LOBO, C BEGLINGER, and A TYNDALL
Gut 2000; 46: 869-872. doi:10.1136/gut.46.6.869 [Extract] [Full text] [PDF] [Request Permissions]

LETTERS TO THE EDITOR

Trypsinogen mutations in hereditary pancreatitis: which nomenclature is convenient? • Reply
V KEIM, N TEICH, J MÖSSNER;, and D C WHITCOMB
Gut 2000; 46: 873. doi:10.1136/gut.46.6.873 [Extract] [Full text] [PDF] [Request Permissions]

Cover

Fluorescent staining of actin cytoskeleton by fluorescein conjugated phalloidin in intestinal monolayers following incubationwith epidermal growth factor before exposure to 0.5 mM HOCl (Fromthe paper by Banan et al, pp 830-837.)

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	British Association for the Study of the Liver Meeting Gut 2000; 46: 1. doi:10.1136/gut.46.6.e1 [PDF] [Request Permissions]

	Hepatic stem cells A J STRAIN and H A CROSBY Gut 2000; 46: 743-745. doi:10.1136/gut.46.6.743 [Extract] [Full text] [PDF] [Request Permissions]

	Colorectal cancer screening in the UK: Joint Position Statement by the British Society of Gastroenterology, the Royal College of Physicians, and the Association of Coloproctology of Great Britain and Ireland JM RHODES Gut 2000; 46: 746-748. doi:10.1136/gut.46.6.746 [Extract] [Full text] [PDF] [Request Permissions]

	Perioperative nutritional support: does it reduce hospital complications or shorten convalescence? J POWELL-TUCK Gut 2000; 46: 749-750. doi:10.1136/gut.46.6.749 [Extract] [Full text] [PDF] [Request Permissions]

	Morphine and biliary pain revisited E A SHAFFER Gut 2000; 46: 750-751. doi:10.1136/gut.46.6.750 [Extract] [Full text] [PDF] [Request Permissions]

	Innate immunity to carcinomas? S J C GOLBY and J SPENCER Gut 2000; 46: 752-753. doi:10.1136/gut.46.6.752 [Extract] [Full text] [PDF] [Request Permissions]

	Symptomatic gastro-oesophageal reflux as a risk factor for oesophageal adenocarcinoma A J CAMERON and Y ROMERO Gut 2000; 46: 754-755. doi:10.1136/gut.46.6.754 [Extract] [Full text] [PDF] [Request Permissions]

	Neuromuscular function of the human lower oesophageal sphincter in reflux disease and Barrett's oesophagus S D Smid and L A Blackshaw Gut 2000; 46: 756-761. doi:10.1136/gut.46.6.756 [Abstract] [Full text] [PDF] [Request Permissions]

	Cough threshold in reflux oesophagitis: influence of acid and of laryngeal and oesophageal damage L Benini, M Ferrari, C Sembenini, M Olivieri, R Micciolo, V Zuccali, G M Bulighin, F Fiorino, A Ederle, V Lo Cascio, and I Vantini Gut 2000; 46: 762-767. doi:10.1136/gut.46.6.762 [Abstract] [Full text] [PDF] [Request Permissions]

	A valid, accurate, office based non-radioactive test for gastric emptying of solids J S Lee, M Camilleri, A R Zinsmeister, D D Burton, L J Kost, and P D Klein Gut 2000; 46: 768-773. doi:10.1136/gut.46.6.768 [Abstract] [Full text] [PDF] [Request Permissions]

	Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor J Borovicka, W Schwizer, G Guttmann, D Hartmann, M Kosinski, C Wastiel, A Bischof-Delaloye, and M Fried Gut 2000; 46: 774-781. doi:10.1136/gut.46.6.774 [Abstract] [Full text] [PDF] [Request Permissions]

	*Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori* related gastritis and gastric ulcer tissues in humans** A Tatsuguchi, C Sakamoto, K Wada, T Akamatsu, T Tsukui, K Miyake, S Futagami, T Kishida, Y Fukuda, N Yamanaka, and M Kobayashi Gut 2000; 46: 782-789. doi:10.1136/gut.46.6.782 [Abstract] [Full text] [PDF] [Request Permissions]

	Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract K Yamashita, Y Arimura, S Kurokawa, F Itoh, T Endo, K Hirata, A Imamura, M Kondo, T Sato, and K Imai Gut 2000; 46: 790-794. doi:10.1136/gut.46.6.790 [Abstract] [Full text] [PDF] [Request Permissions]

	Faecal calprotectin levels in a high risk population for colorectal neoplasia O Kronborg, M Ugstad, P Fuglerud, B Johne, J Hardcastle, J H Scholefield, K Vellacott, V Moshakis, and J R Reynolds Gut 2000; 46: 795-800. doi:10.1136/gut.46.6.795 [Abstract] [Full text] [PDF] [Request Permissions]

	A new variable stiffness colonoscope makes colonoscopy easier: a randomised controlled trial J C Brooker, B P Saunders, S G Shah, and C B Williams Gut 2000; 46: 801-805. doi:10.1136/gut.46.6.801 [Abstract] [Full text] [PDF] [Request Permissions]

	*Do eicosanoids cause colonic dysfunction in experimental E coli* 0157:H7 (EHEC) infection?** C J Bell, E J Elliott, J L Wallace, D M Redmond, J Payne, Z Li, and E V O'Loughlin Gut 2000; 46: 806-812. doi:10.1136/gut.46.6.806 [Abstract] [Full text] [PDF] [Request Permissions]

	A randomised controlled trial evaluating the use of enteral nutritional supplements postoperatively in malnourished surgical patients A H Beattie, A T Prach, J P Baxter, and C R Pennington Gut 2000; 46: 813-818. doi:10.1136/gut.46.6.813 [Abstract] [Full text] [PDF] [Request Permissions]

	Absorption of calcium and magnesium in patients with intestinal resections treated with medium chain fatty acids K V Haderslev, P B Jeppesen, P B Mortensen, and M Staun Gut 2000; 46: 819-823. doi:10.1136/gut.46.6.819 [Abstract] [Full text] [PDF] [Request Permissions]

	Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: a study of a concept S Björck, I Bosaeus, E Ek, E Jennische, I Lönnroth, E Johansson, and S Lange Gut 2000; 46: 824-829. doi:10.1136/gut.46.6.824 [Abstract] [Full text] [PDF] [Request Permissions]

	Carbonylation and disassembly of the F-actin cytoskeleton in oxidant induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor $alpha$ in a human colonic cell line A Banan, Y Zhang, J Losurdo, and A Keshavarzian Gut 2000; 46: 830-837. doi:10.1136/gut.46.6.830 [Abstract] [Full text] [PDF] [Request Permissions]

	Use of ^99mTc-DISIDA biliary scanning with morphine provocation for the detection of elevated sphincter of Oddi basal pressure P D Thomas, J G Turner, B R Dobbs, M J Burt, and B A Chapman Gut 2000; 46: 838-841. doi:10.1136/gut.46.6.838 [Abstract] [Full text] [PDF] [Request Permissions]

	Cancer of the ampulla of Vater: chromosome 17p allelic loss is associated with poor prognosis A Scarpa, C Di Pace, G Talamini, M Falconi, N R Lemoine, C Iacono, A Achille, A Baron, and G Zamboni Gut 2000; 46: 842-848. doi:10.1136/gut.46.6.842 [Abstract] [Full text] [PDF] [Request Permissions]

	Post-feeding hyperammonaemia in patients with transjugular intrahepatic portosystemic shunt and liver cirrhosis: role of small intestinal ammonia release and route of nutrient administration M Plauth, A-E Roske, P Romaniuk, E Roth, R Ziebig, and H Lochs Gut 2000; 46: 849-855. doi:10.1136/gut.46.6.849 [Abstract] [Full text] [PDF] [Request Permissions]

	CO₂ wedged hepatic venography in the evaluation of portal hypertension W Debernardi-Venon, J-C Bandi, J-C García-Pagán, E Moitinho, V Andreu, M Real, A Escorsell, X Montanyá, and J Bosch Gut 2000; 46: 856-860. doi:10.1136/gut.46.6.856 [Abstract] [Full text] [PDF] [Request Permissions]

	Neuromyogenic properties of the internal anal sphincter: therapeutic rationale for anal fissures R BHARDWAJ, C J VAIZEY, P B BOULOS, and C H V HOYLE Gut 2000; 46: 861-868. doi:10.1136/gut.46.6.861 [Extract] [Full text] [PDF] [Request Permissions]

	Stem cell transplantation for inflammatory bowel disease: practical and ethical issues C J HAWKEY, J A SNOWDEN, A LOBO, C BEGLINGER, and A TYNDALL Gut 2000; 46: 869-872. doi:10.1136/gut.46.6.869 [Extract] [Full text] [PDF] [Request Permissions]

	Trypsinogen mutations in hereditary pancreatitis: which nomenclature is convenient? • Reply V KEIM, N TEICH, J MÖSSNER;, and D C WHITCOMB Gut 2000; 46: 873. doi:10.1136/gut.46.6.873 [Extract] [Full text] [PDF] [Request Permissions]