Leading articles

	The science, economics, and effectiveness of combination therapy for hepatitis C G DUSHEIKO, E BARNES, G WEBSTER, and S WHALLEY Gut 2000; 47: 159-161. doi:10.1136/gut.47.2.159 [Extract] [Full text] [PDF] [Request Permissions]
	Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease N FRENCH and S PETTERSSON Gut 2000; 47: 162-163. doi:10.1136/gut.47.2.162 [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	Effect of growth hormone and glutamine on the short bowel: five years later J S SCOLAPIO Gut 2000; 47: 164-165. doi:10.1136/gut.47.2.164 [Extract] [Full text] [PDF] [Request Permissions]
	Screening and shouting about HCV W ROSENBERG Gut 2000; 47: 165-166. doi:10.1136/gut.47.2.165 [Extract] [Full text] [PDF] [Request Permissions]
	Improving prognosis in hepatorenal syndrome P A MCCORMICK Gut 2000; 47: 166-167. doi:10.1136/gut.47.2.166 [Extract] [Full text] [PDF] [Request Permissions]

Science alerts

	The stomach talks with the pituitary O LUNDGREN Gut 2000; 47: 168-169. doi:10.1136/gut.47.2.168 [Extract] [Full text] [PDF] [Request Permissions]

Stomach

	The role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extract L Ma, W P Wang, J Y C Chow, S K Lam, and C H Cho Gut 2000; 47: 170-177. doi:10.1136/gut.47.2.170 [Abstract] [Full text] [PDF] [Request Permissions]
	Leptin secretion and leptin receptor in the human stomach I Sobhani, A Bado, C Vissuzaine, M Buyse, S Kermorgant, J-P Laigneau, S Attoub, T Lehy, D Henin, M Mignon, and M J M Lewin Gut 2000; 47: 178-183. doi:10.1136/gut.47.2.178 [Abstract] [Full text] [PDF] [Request Permissions]

Small intestine

	Effect of proinflammatory interleukins on jejunal nutrient transport J Hardin, K Kroeker, B Chung, and D G Gall Gut 2000; 47: 184-191. doi:10.1136/gut.47.2.184 [Abstract] [Full text] [PDF] [Request Permissions]
	Cytokine gene expression during postnatal small intestinal development: regulation by glucocorticoids C Schaeffer, M Diab-Assef, M Plateroti, F Laurent-Huck, J M Reimund, M Kedinger, and C Foltzer-Jourdainne Gut 2000; 47: 192-198. doi:10.1136/gut.47.2.192 [Abstract] [Full text] [PDF] [Request Permissions]
	Effect of high dose growth hormone with glutamine and no change in diet on intestinal absorption in short bowel patients: a randomised, double blind, crossover, placebo controlled study J Szkudlarek, P B Jeppesen, and P B Mortensen Gut 2000; 47: 199-205. doi:10.1136/gut.47.2.199 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

	Thiol methyltransferase activity in inflammatory bowel disease W E Roediger and W J Babidge Gut 2000; 47: 206-210. doi:10.1136/gut.47.2.206 [Abstract] [Full text] [PDF] [Request Permissions]
	Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility J D Simmons, C Mullighan, K I Welsh, and D P Jewell Gut 2000; 47: 211-214. doi:10.1136/gut.47.2.211 [Abstract] [Full text] [PDF] [Request Permissions]
	Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR- expression M M-W Yeung, S Melgar, V Baranov, Å Öberg, Å Danielsson, S Hammarström, and M-L Hammarström Gut 2000; 47: 215-227. doi:10.1136/gut.47.2.215 [Abstract] [Full text] [PDF] [Request Permissions]
	Bax is downregulated in inflamed colonic mucosa of ulcerative colitis M Iimura, T Nakamura, S Shinozaki, B Iizuka, Y Inoue, S Suzuki, and N Hayashi Gut 2000; 47: 228-235. doi:10.1136/gut.47.2.228 [Abstract] [Full text] [PDF] [Request Permissions]
	Autoantibodies against the specific epitope of human tropomyosin(s) detected by a peptide based enzyme immunoassay in sera of patients with ulcerative colitis show antibody dependent cell mediated cytotoxicity against HLA-DPw9 transfected L cells S Sakamaki, N Takayanagi, N Yoshizaki, S Hayashi, T Takayama, J Kato, K Kogawa, N Yamauchi, N Takemoto, A Nobuoka, T Ayabe, Y Kohgo, and Y Niitsu Gut 2000; 47: 236-241. doi:10.1136/gut.47.2.236 [Abstract] [Full text] [PDF] [Request Permissions]

Epithelial proliferation

	Alpha2 adrenoceptors regulate proliferation of human intestinal epithelial cells S Schaak, D Cussac, C Cayla, J C Devedjian, R Guyot, H Paris, and C Denis Gut 2000; 47: 242-250. doi:10.1136/gut.47.2.242 [Abstract] [Full text] [PDF] [Request Permissions]

Cancer

	The Vienna classification of gastrointestinal epithelial neoplasia R J Schlemper, R H Riddell, Y Kato, F Borchard, H S Cooper, S M Dawsey, M F Dixon, C M Fenoglio-Preiser, J-F Fléjou, K Geboes, T Hattori, T Hirota, M Itabashi, M Iwafuchi, A Iwashita, Y I Kim, T Kirchner, M Klimpfinger, M Koike, G Y Lauwers, K J Lewin, G Oberhuber, F Offner, A B Price, C A Rubio, M Shimizu, T Shimoda, P Sipponen, E Solcia, M Stolte, H Watanabe, and H Yamabe Gut 2000; 47: 251-255. doi:10.1136/gut.47.2.251 [Abstract] [Full text] [PDF] [Request Permissions]
	Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients M Muto, Y Hitomi, A Ohtsu, S Ebihara, S Yoshida, and H Esumi Gut 2000; 47: 256-261. doi:10.1136/gut.47.2.256 [Abstract] [Full text] [PDF] [Request Permissions]
	The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea H C Kim, J M D Wheeler, J C Kim, M Ilyas, N E Beck, B S Kim, K C Park, and W F Bodmer Gut 2000; 47: 262-267. doi:10.1136/gut.47.2.262 [Abstract] [Full text] [PDF] [Request Permissions]
	Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers Y Takagi, M Futamura, K Yamaguchi, S Aoki, T Takahashi, and S Saji Gut 2000; 47: 268-271. doi:10.1136/gut.47.2.268 [Abstract] [Full text] [PDF] [Request Permissions]
	5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer J Trojan, A Brieger, J Raedle, M Esteller, and S Zeuzem Gut 2000; 47: 272-276. doi:10.1136/gut.47.2.272 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

	Prevalence of hepatitis C among pregnant women attending an inner London obstetric department: uptake and acceptability of named antenatal testing C Ward, G Tudor-Williams, T Cotzias, S Hargreaves, L Regan, and G R Foster Gut 2000; 47: 277-280. doi:10.1136/gut.47.2.277 [Abstract] [Full text] [PDF] [Request Permissions]
	Mechanisms of endotoxin tolerance in patients with alcoholic liver cirrhosis: role of interleukin 10, interleukin 1 receptor antagonist, and soluble tumour necrosis factor receptors as well as effector cell desensitisation V von Baehr, W-D Döcke, M Plauth, C Liebenthal, S Küpferling, H Lochs, R Baumgarten, and H-D Volk Gut 2000; 47: 281-287. doi:10.1136/gut.47.2.281 [Abstract] [Full text] [PDF] [Request Permissions]
	Long term outcome after transjugular intrahepatic portosystemic stent-shunt in non-transplant cirrhotics with hepatorenal syndrome: a phase II study K A Brensing, J Textor, J Perz, P Schiedermaier, P Raab, H Strunk, H U Klehr, H J Kramer, U Spengler, H Schild, and T Sauerbruch Gut 2000; 47: 288-295. doi:10.1136/gut.47.2.288 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

	Very late onset small intestinal B cell lymphoma associated with primary intestinal lymphangiectasia and diffuse cutaneous warts Y Bouhnik, I Etienney, J Nemeth, T Thevenot, A Lavergne-Slove, and C Matuchansky Gut 2000; 47: 296-300. doi:10.1136/gut.47.2.296 [Abstract] [Full text] [PDF] [Request Permissions]

Gut file

	Needle tract recurrence of hepatocellular carcinoma after liver transplantation J DUMORTIER, C LOMBARD-BOHAS, P-J VALETTE, O BOILLOT, J DUMORTIER, O BOILLOT, J-Y SCOAZEC, F BERGER, and S CLAUDEL-BONVOISIN Gut 2000; 47: 301. doi:10.1136/gut.47.2.301 [Extract] [Full text] [PDF] [Request Permissions]

Personal viewpoint

	Epigenetics of inflammatory bowel disease A PETRONIS and R PETRONIENE Gut 2000; 47: 302-306. doi:10.1136/gut.47.2.302 [Extract] [Full text] [PDF] [Request Permissions]

Occasional viewpoint

	Is the colonic reparative cell lineage yet to be discovered? R J LONGMAN and B F WARREN Gut 2000; 47: 307-308. doi:10.1136/gut.47.2.307 [Extract] [Full text] [PDF] [Request Permissions]

Reviews

	Interleukin 6 and liver regeneration K L STREETZ, T LUEDDE, M P MANNS, and C TRAUTWEIN Gut 2000; 47: 309-312. doi:10.1136/gut.47.2.309 [Extract] [Full text] [PDF] [Request Permissions]

Letters to the editor

	Timing of transfusion, anti-HBc, and hepatitis C virus related hepatocellular carcinoma • Reply S DE A NISHIOKA;, H MARUSAWA, and T CHIBA Gut 2000; 47: 313. doi:10.1136/gut.47.2.313 [Extract] [Full text] [PDF] [Request Permissions]
	Acid secretion in H pylori associated enlarged fold gastritis • Reply I L P BEALES;, Y MURAYAMA, J MIYAGAWA, S KANAYAMA, and Y SHINOMURA Gut 2000; 47: 313-314. doi:10.1136/gut.47.2.313a [Extract] [Full text] [PDF] [Request Permissions]
	Is there any relationship between IEL and lymphoid follicles in the gastric mucosa? • Reply G CAMMAROTA, G GASBARRINI;, and M HAYAT Gut 2000; 47: 314-315. doi:10.1136/gut.47.2.314 [Extract] [Full text] [PDF] [Request Permissions]
	hMLH1 and hMSH2 immunostaining in colorectal cancer • Reply • Reply J R JASS;, L CAWKWELL, M F DIXON, P QUIRKE;, and I TALBOT Gut 2000; 47: 315-316. doi:10.1136/gut.47.2.315 [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Proton Pump Inhibitors M E PARSONS Gut 2000; 47: 316. doi:10.1136/gut.47.2.316 [Extract] [Full text] [PDF] [Request Permissions]