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January 2001 (Volume 48, Number 1). [Index by author]

	(Cover illustration)	Leading articles Commentaries Science alerts Clinical alerts Irritable bowel syndrome Nutrition Growth factor Colon cancer Pancreatic tract Biliary tract Liver disease Case reports Occasional viewpoint Reviews Letters to the editor Corrections

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Leading articles

Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes
R HOULSTON, M CRABTREE, R PHILLIPS, M CRABTREE, and I TOMLINSON
Gut 2001; 48: 1-5. doi:10.1136/gut.48.1.1 [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

A role for IL-18 in intestinal inflammation?
P GARSIDE
Gut 2001; 48: 6-7. doi:10.1136/gut.48.1.6 [Extract] [Full text] [PDF] [Request Permissions]

Autoimmune hepatitis: a fertile field
J R LAKE
Gut 2001; 48: 7-8. doi:10.1136/gut.48.1.7 [Extract] [Full text] [PDF] [Request Permissions]

HCV in healthcare workers: a lightning strike
H C THOMAS
Gut 2001; 48: 8-9. doi:10.1136/gut.48.1.8 [Extract] [Full text] [PDF] [Request Permissions]

Science alerts

The worm turns on Helicobacter pylori
T T MACDONALD
Gut 2001; 48: 10-11. doi:10.1136/gut.48.1.10 [Extract] [Full text] [PDF] [Request Permissions]

Clinical alerts

Multivitamins, folate, and colon cancer
J LITTLE
Gut 2001; 48: 12-13. doi:10.1136/gut.48.1.12 [Extract] [Full text] [PDF] [Request Permissions]

Irritable bowel syndrome

Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome
J Serra, F Azpiroz, and J-R Malagelada
Gut 2001; 48: 14-19. doi:10.1136/gut.48.1.14 [Abstract] [Full text] [PDF] [Request Permissions]

An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome
M Simrén, H Abrahamsson, and E S Björnsson
Gut 2001; 48: 20-27. doi:10.1136/gut.48.1.20 [Abstract] [Full text] [PDF] [Request Permissions]

Nutrition

Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial
B Daniele, F Perrone, C Gallo, S Pignata, S De Martino, R De Vivo, E Barletta, R Tambaro, R Abbiati, and L D'Agostino
Gut 2001; 48: 28-33. doi:10.1136/gut.48.1.28 [Abstract] [Full text] [PDF] [Request Permissions]

Growth factor

Epidermal growth factor reduces multiorgan failure induced by thioacetamide
M E Caballero, J Berlanga, D Ramirez, P Lopez-Saura, R Gozalez, D N Floyd, T Marchbank, and R J Playford
Gut 2001; 48: 34-40. doi:10.1136/gut.48.1.34 [Abstract] [Full text] [PDF] [Request Permissions]

Colon cancer

Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis
S J Mills, J C Mathers, P D Chapman, J Burn, and A Gunn
Gut 2001; 48: 41-46. doi:10.1136/gut.48.1.41 [Abstract] [Full text] [PDF] [Request Permissions]

Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma
R K Siddheshwar, J C Gray, and S B Kelly
Gut 2001; 48: 47-52. doi:10.1136/gut.48.1.47 [Abstract] [Full text] [PDF] [Request Permissions]

Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats
P Perrin, F Pierre, Y Patry, M Champ, M Berreur, G Pradal, F Bornet, K Meflah, and J Menanteau
Gut 2001; 48: 53-61. doi:10.1136/gut.48.1.53 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatic tract

Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis
C D Johnson, A N Kingsnorth, C W Imrie, M J McMahon, J P Neoptolemos, C McKay, S K C Toh, P Skaife, P C Leeder, P Wilson, M Larvin, and L D Curtis
Gut 2001; 48: 62-69. doi:10.1136/gut.48.1.62 [Abstract] [Full text] [PDF] [Request Permissions]

Cystic fibrosis transmembrane regulator (CFTR) $Delta$ F508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer
N Malats, T Casals, M Porta, L Guarner, X Estivill, and F X Real
Gut 2001; 48: 70-74. doi:10.1136/gut.48.1.70 [Abstract] [Full text] [PDF] [Request Permissions]

Biliary tract

Fatty acid bile acid conjugates (FABACs) $---$ New molecules for the prevention of cholesterol crystallisation in bile
T Gilat, G J Somjen, Y Mazur, A Leikin-Frenkel, R Rosenberg, Z Halpern, and FM Konikoff
Gut 2001; 48: 75-79. doi:10.1136/gut.48.1.75 [Abstract] [Full text] [PDF] [Request Permissions]

Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma
S Chariyalertsak, V Sirikulchayanonta, D Mayer, A Kopp-Schneider, G Fürstenberger, F Marks, and K Müller-Decker
Gut 2001; 48: 80-86. doi:10.1136/gut.48.1.80 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma
Z von Marschall, T Cramer, M Höcker, G Finkenzeller, B Wiedenmann, and S Rosewicz
Gut 2001; 48: 87-96. doi:10.1136/gut.48.1.87 [Abstract] [Full text] [PDF] [Request Permissions]

Management and outcome of pregnancy in autoimmune hepatitis
M A Heneghan, S M Norris, J G O'Grady, P M Harrison, and I G McFarlane
Gut 2001; 48: 97-102. doi:10.1136/gut.48.1.97 [Abstract] [Full text] [PDF] [Request Permissions]

Hepatocellular carcinoma in Central Europe: prognostic features and survival
M Schöniger-Hekele, C Müller, M Kutilek, C Oesterreicher, P Ferenci, and A Gangl
Gut 2001; 48: 103-109. doi:10.1136/gut.48.1.103 [Abstract] [Full text] [PDF] [Request Permissions]

Evidence for an association between the aetiology of cirrhosis and pattern of hepatocellular carcinoma development
L Benvegnù, F Noventa, E Bernardinello, P Pontisso, A Gatta, and A Alberti
Gut 2001; 48: 110-115. doi:10.1136/gut.48.1.110 [Abstract] [Full text] [PDF] [Request Permissions]

A study of hepatitis C prevalence in healthcare workers in the West of Scotland
D Thorburn, D Dundas, E A B McCruden, S O Cameron, D J Goldberg, I S Symington, A Kirk, and P R Mills
Gut 2001; 48: 116-120. doi:10.1136/gut.48.1.116 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

Mitochondrial enteropathy: the primary pathology may not be within the gastrointestinal tract
P F Chinnery, S Jones, L Sviland, R M Andrews, T J Parsons, D M Turnbull, and L A Bindoff
Gut 2001; 48: 121-124. doi:10.1136/gut.48.1.121 [Abstract] [Full text] [PDF] [Request Permissions]

Occasional viewpoint

Visceral hypersensitivity: facts, speculations, and challenges
M CAMILLERI, B COULIE, and J F TACK
Gut 2001; 48: 125-131. doi:10.1136/gut.48.1.125 [Extract] [Full text] [PDF] [Request Permissions]

Reviews

Bacteria as the cause of ulcerative colitis
MASSIMO CAMPIERI and PAOLO GIONCHETTI
Gut 2001; 48: 132-135. doi:10.1136/gut.48.1.132 [Extract] [Full text] [PDF] [Request Permissions]

Letters to the editor

Immunohistochemical analysis of measles related antigen in IBD • Reply
A J WAKEFIELD, S M MONTGOMERY, M IIZUKA, S WATANABE, M CHIBA, and O NAKAGOMI
Gut 2001; 48: 136-137. doi:10.1136/gut.48.1.136 [Extract] [Full text] [PDF] [Request Permissions]

Survivin gene expression and prognosis in recurrent colorectal cancer • Reply
M MILLER, D SMITH, A WINDSOR, A KESSLING, A I SARELA, S M FARMERY, and P J GUILLOU
Gut 2001; 48: 137-138. doi:10.1136/gut.48.1.137 [Extract] [Full text] [PDF] [Request Permissions]

Corrections

Correction for vol. 47, p. 11
Gut 2001; 48: 138. doi:10.1136/gut.48.1.138 [Extract] [Full text] [PDF] [Request Permissions]

Cover

Changes over time in the relationships between the major short chain fatty acids in four diets with different fibre content.(From the paper by Perrin et al, pp 61-69.)

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	Explaining differences in the severity of familial adenomatous polyposis and the search for modifier genes R HOULSTON, M CRABTREE, R PHILLIPS, M CRABTREE, and I TOMLINSON Gut 2001; 48: 1-5. doi:10.1136/gut.48.1.1 [Extract] [Full text] [PDF] [Request Permissions]

	A role for IL-18 in intestinal inflammation? P GARSIDE Gut 2001; 48: 6-7. doi:10.1136/gut.48.1.6 [Extract] [Full text] [PDF] [Request Permissions]

	Autoimmune hepatitis: a fertile field J R LAKE Gut 2001; 48: 7-8. doi:10.1136/gut.48.1.7 [Extract] [Full text] [PDF] [Request Permissions]

	HCV in healthcare workers: a lightning strike H C THOMAS Gut 2001; 48: 8-9. doi:10.1136/gut.48.1.8 [Extract] [Full text] [PDF] [Request Permissions]

	The worm turns on Helicobacter pylori T T MACDONALD Gut 2001; 48: 10-11. doi:10.1136/gut.48.1.10 [Extract] [Full text] [PDF] [Request Permissions]

	Multivitamins, folate, and colon cancer J LITTLE Gut 2001; 48: 12-13. doi:10.1136/gut.48.1.12 [Extract] [Full text] [PDF] [Request Permissions]

	Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome J Serra, F Azpiroz, and J-R Malagelada Gut 2001; 48: 14-19. doi:10.1136/gut.48.1.14 [Abstract] [Full text] [PDF] [Request Permissions]

	An exaggerated sensory component of the gastrocolonic response in patients with irritable bowel syndrome M Simrén, H Abrahamsson, and E S Björnsson Gut 2001; 48: 20-27. doi:10.1136/gut.48.1.20 [Abstract] [Full text] [PDF] [Request Permissions]

	Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial B Daniele, F Perrone, C Gallo, S Pignata, S De Martino, R De Vivo, E Barletta, R Tambaro, R Abbiati, and L D'Agostino Gut 2001; 48: 28-33. doi:10.1136/gut.48.1.28 [Abstract] [Full text] [PDF] [Request Permissions]

	Epidermal growth factor reduces multiorgan failure induced by thioacetamide M E Caballero, J Berlanga, D Ramirez, P Lopez-Saura, R Gozalez, D N Floyd, T Marchbank, and R J Playford Gut 2001; 48: 34-40. doi:10.1136/gut.48.1.34 [Abstract] [Full text] [PDF] [Request Permissions]

	Colonic crypt cell proliferation state assessed by whole crypt microdissection in sporadic neoplasia and familial adenomatous polyposis S J Mills, J C Mathers, P D Chapman, J Burn, and A Gunn Gut 2001; 48: 41-46. doi:10.1136/gut.48.1.41 [Abstract] [Full text] [PDF] [Request Permissions]

	Plasma levels of progastrin but not amidated gastrin or glycine extended gastrin are elevated in patients with colorectal carcinoma R K Siddheshwar, J C Gray, and S B Kelly Gut 2001; 48: 47-52. doi:10.1136/gut.48.1.47 [Abstract] [Full text] [PDF] [Request Permissions]

	Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats P Perrin, F Pierre, Y Patry, M Champ, M Berreur, G Pradal, F Bornet, K Meflah, and J Menanteau Gut 2001; 48: 53-61. doi:10.1136/gut.48.1.53 [Abstract] [Full text] [PDF] [Request Permissions]

	Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis C D Johnson, A N Kingsnorth, C W Imrie, M J McMahon, J P Neoptolemos, C McKay, S K C Toh, P Skaife, P C Leeder, P Wilson, M Larvin, and L D Curtis Gut 2001; 48: 62-69. doi:10.1136/gut.48.1.62 [Abstract] [Full text] [PDF] [Request Permissions]

	*Cystic fibrosis transmembrane regulator (CFTR) $Delta$ F508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer* N Malats, T Casals, M Porta, L Guarner, X Estivill, and F X Real Gut 2001; 48: 70-74. doi:10.1136/gut.48.1.70 [Abstract] [Full text] [PDF] [Request Permissions]

	Fatty acid bile acid conjugates (FABACs) $---$ New molecules for the prevention of cholesterol crystallisation in bile T Gilat, G J Somjen, Y Mazur, A Leikin-Frenkel, R Rosenberg, Z Halpern, and FM Konikoff Gut 2001; 48: 75-79. doi:10.1136/gut.48.1.75 [Abstract] [Full text] [PDF] [Request Permissions]

	Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma S Chariyalertsak, V Sirikulchayanonta, D Mayer, A Kopp-Schneider, G Fürstenberger, F Marks, and K Müller-Decker Gut 2001; 48: 80-86. doi:10.1136/gut.48.1.80 [Abstract] [Full text] [PDF] [Request Permissions]

	Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma Z von Marschall, T Cramer, M Höcker, G Finkenzeller, B Wiedenmann, and S Rosewicz Gut 2001; 48: 87-96. doi:10.1136/gut.48.1.87 [Abstract] [Full text] [PDF] [Request Permissions]

	Management and outcome of pregnancy in autoimmune hepatitis M A Heneghan, S M Norris, J G O'Grady, P M Harrison, and I G McFarlane Gut 2001; 48: 97-102. doi:10.1136/gut.48.1.97 [Abstract] [Full text] [PDF] [Request Permissions]

	Hepatocellular carcinoma in Central Europe: prognostic features and survival M Schöniger-Hekele, C Müller, M Kutilek, C Oesterreicher, P Ferenci, and A Gangl Gut 2001; 48: 103-109. doi:10.1136/gut.48.1.103 [Abstract] [Full text] [PDF] [Request Permissions]

	Evidence for an association between the aetiology of cirrhosis and pattern of hepatocellular carcinoma development L Benvegnù, F Noventa, E Bernardinello, P Pontisso, A Gatta, and A Alberti Gut 2001; 48: 110-115. doi:10.1136/gut.48.1.110 [Abstract] [Full text] [PDF] [Request Permissions]

	A study of hepatitis C prevalence in healthcare workers in the West of Scotland D Thorburn, D Dundas, E A B McCruden, S O Cameron, D J Goldberg, I S Symington, A Kirk, and P R Mills Gut 2001; 48: 116-120. doi:10.1136/gut.48.1.116 [Abstract] [Full text] [PDF] [Request Permissions]

	Mitochondrial enteropathy: the primary pathology may not be within the gastrointestinal tract P F Chinnery, S Jones, L Sviland, R M Andrews, T J Parsons, D M Turnbull, and L A Bindoff Gut 2001; 48: 121-124. doi:10.1136/gut.48.1.121 [Abstract] [Full text] [PDF] [Request Permissions]

	Visceral hypersensitivity: facts, speculations, and challenges M CAMILLERI, B COULIE, and J F TACK Gut 2001; 48: 125-131. doi:10.1136/gut.48.1.125 [Extract] [Full text] [PDF] [Request Permissions]

	Bacteria as the cause of ulcerative colitis MASSIMO CAMPIERI and PAOLO GIONCHETTI Gut 2001; 48: 132-135. doi:10.1136/gut.48.1.132 [Extract] [Full text] [PDF] [Request Permissions]

	Immunohistochemical analysis of measles related antigen in IBD • Reply A J WAKEFIELD, S M MONTGOMERY, M IIZUKA, S WATANABE, M CHIBA, and O NAKAGOMI Gut 2001; 48: 136-137. doi:10.1136/gut.48.1.136 [Extract] [Full text] [PDF] [Request Permissions]

	Survivin gene expression and prognosis in recurrent colorectal cancer • Reply M MILLER, D SMITH, A WINDSOR, A KESSLING, A I SARELA, S M FARMERY, and P J GUILLOU Gut 2001; 48: 137-138. doi:10.1136/gut.48.1.137 [Extract] [Full text] [PDF] [Request Permissions]

	Correction for vol. 47, p. 11 Gut 2001; 48: 138. doi:10.1136/gut.48.1.138 [Extract] [Full text] [PDF] [Request Permissions]