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February 2001 (Volume 48, Number 2). [Index by author]

	(Cover illustration)	Leading articles Commentaries Science alerts Clinical alerts Helicobacter pylori Small intestine Inflammatory bowel disease Intestinal microflora Motility and visceral sensation Gastrointestinal cancer Pancreatic disease Liver disease Case reports Reviews Letters to the editor Corrections

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Leading articles

Inherited predisposition to pancreatic cancer
E EFTHIMIOU, T CRNOGORAC-JURCEVIC, N R LEMOINE, and T A BRENTNALL
Gut 2001; 48: 143-147. doi:10.1136/gut.48.2.143 [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

Is bacterial ash the flash that ignites NASH?
G C FARRELL
Gut 2001; 48: 148-149. doi:10.1136/gut.48.2.148 [Extract] [Full text] [PDF] [Request Permissions]

Hepatocellular carcinoma: is surveillance cost effective?
J BRUIX and J M LLOVET
Gut 2001; 48: 149-150. doi:10.1136/gut.48.2.149 [Extract] [Full text] [PDF] [Request Permissions]

Endoscopic mucosal resection for early gastric cancer
S O'MAHONY
Gut 2001; 48: 151-152. doi:10.1136/gut.48.2.151 [Extract] [Full text] [PDF] [Request Permissions]

Science alerts

Adult liver stem cells: bone marrow, blood, or liver derived?
H A CROSBY and A J STRAIN
Gut 2001; 48: 153-154. doi:10.1136/gut.48.2.153 [Extract] [Full text] [PDF] [Request Permissions]

Clinical alerts

Urgent endoscopy in lower gastrointestinal bleeding
J L H WONG and H R DALTON
Gut 2001; 48: 155-156. doi:10.1136/gut.48.2.155 [Extract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori

Helicobacter pylori augments the acid inhibitory effect of omeprazole on parietal cells and gastric H⁺/K⁺-ATPase
W Beil, K-F Sewing, R Busche, and S Wagner
Gut 2001; 48: 157-162. doi:10.1136/gut.48.2.157 [Abstract] [Full text] [PDF] [Request Permissions]

Small intestine

Protective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: a new mechanism
A Z A Leite, A M Sipahi, A O M C Damião, A M M Coelho, A T Garcez, M C C Machado, C A Buchpiguel, F P Lopasso, M L Lordello, C L O Agostinho, and A A Laudanna
Gut 2001; 48: 163-167. doi:10.1136/gut.48.2.163 [Abstract] [Full text] [PDF] [Request Permissions]

Fructose-1,6-biphosphate in rat intestinal preconditioning: involvement of nitric oxide
A Sola, J Roselló-Catafau, E Gelpí, and G Hotter
Gut 2001; 48: 168-175. doi:10.1136/gut.48.2.168 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammatory bowel disease

Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease
R N Cunliffe, F R A J Rose, J Keyte, L Abberley, W C Chan, and Y R Mahida
Gut 2001; 48: 176-185. doi:10.1136/gut.48.2.176 [Abstract] [Full text] [PDF] [Request Permissions]

Switch from systemic steroids to budesonide in steroid dependent patients with inactive Crohn's disease
A Cortot, J-F Colombel, P Rutgeerts, K Lauritsen, H Malchow, J Hämling, T Winter, A Van Gossum, T Persson, and E Pettersson
Gut 2001; 48: 186-190. doi:10.1136/gut.48.2.186 [Abstract] [Full text] [PDF] [Request Permissions]

Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease
J Hampe, N J Lynch, S Daniels, S Bridger, A J S Macpherson, P Stokkers, A Forbes, J E Lennard-Jones, C G Mathew, M E Curran, and S Schreiber
Gut 2001; 48: 191-197. doi:10.1136/gut.48.2.191 [Abstract] [Full text] [PDF] [Request Permissions]

Intestinal microflora

Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles
M J Hopkins, R Sharp, and G T Macfarlane
Gut 2001; 48: 198-205. doi:10.1136/gut.48.2.198 [Abstract] [Full text] [PDF] [Request Permissions]

The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor $alpha$ in the pathogenesis of non-alcoholic steatohepatitis
A J Wigg, I C Roberts-Thomson, R B Dymock, P J McCarthy, R H Grose, and A G Cummins
Gut 2001; 48: 206-211. doi:10.1136/gut.48.2.206 [Abstract] [Full text] [PDF] [Request Permissions]

Motility and visceral sensation

Gastric dysrhythmias occur in gastro-oesophageal reflux disease complicated by food regurgitation but not in uncomplicated reflux
A Leahy, K Besherdas, C Clayman, I Mason, and O Epstein
Gut 2001; 48: 212-215. doi:10.1136/gut.48.2.212 [Abstract] [Full text] [PDF] [Request Permissions]

Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome
M J V Lewis, B Reilly, L A Houghton, and P J Whorwell
Gut 2001; 48: 216-220. doi:10.1136/gut.48.2.216 [Abstract] [Full text] [PDF] [Request Permissions]

Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure
J Lysy, Y Israelit-Yatzkan, M Sestiery-Ittah, S Weksler-Zangen, D Keret, and E Goldin
Gut 2001; 48: 221-224. doi:10.1136/gut.48.2.221 [Abstract] [Full text] [PDF] [Request Permissions]

Gastrointestinal cancer

Endoscopic mucosal resection for treatment of early gastric cancer
H Ono, H Kondo, T Gotoda, K Shirao, H Yamaguchi, D Saito, K Hosokawa, T Shimoda, and S Yoshida
Gut 2001; 48: 225-229. doi:10.1136/gut.48.2.225 [Abstract] [Full text] [PDF] [Request Permissions]

Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma
H J N Andreyev, P J Ross, D Cunningham, and P A Clarke
Gut 2001; 48: 230-237. doi:10.1136/gut.48.2.230 [Abstract] [Full text] [PDF] [Request Permissions]

Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas
M Anti, A Armuzzi, S Morini, E Iascone, G Pignataro, C Coco, R Lorenzetti, M Paolucci, M Covino, A Gasbarrini, FM Vecchio, and G Gasbarrini
Gut 2001; 48: 238-246. doi:10.1136/gut.48.2.238 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatic disease

A new polymorphism for the RI22H mutation in hereditary pancreatitis
N Howes, W Greenhalf, S Rutherford, M O'Donnell, R Mountford, I Ellis, D Whitcomb, C Imrie, B Drumm, and J P Neoptolemos
Gut 2001; 48: 247-250. doi:10.1136/gut.48.2.247 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis
L Bolondi, S Sofia, S Siringo, S Gaiani, A Casali, G Zironi, F Piscaglia, L Gramantieri, M Zanetti, and M Sherman
Gut 2001; 48: 251-259. doi:10.1136/gut.48.2.251 [Abstract] [Full text] [PDF] [Request Permissions]

Increased risk and case fatality rate of pyogenic liver abscess in patients with liver cirrhosis: a nationwide study in Denmark
I Mølle, A M Thulstrup, H Vilstrup, and H T Sørensen
Gut 2001; 48: 260-263. doi:10.1136/gut.48.2.260 [Abstract] [Full text] [PDF] [Request Permissions]

Factor V Leiden related Budd-Chiari syndrome
P Deltenre, M-H Denninger, S Hillaire, M-C Guillin, N Casadevall, J Brière, S Erlinger, and D-C Valla
Gut 2001; 48: 264-268. doi:10.1136/gut.48.2.264 [Abstract] [Full text] [PDF] [Request Permissions]

Case reports

Regression of gastric T cell lymphoma with eradication of Helicobacter pylori
C Bariol, A Field, C R Vickers, and R Ward
Gut 2001; 48: 269-271. doi:10.1136/gut.48.2.269 [Abstract] [Full text] [PDF] [Request Permissions]

Reviews

Treatment of irritable bowel syndrome: a review of randomised controlled trials
R AKEHURST and E KALTENTHALER
Gut 2001; 48: 272-282. doi:10.1136/gut.48.2.272 [Abstract] [Full text] [PDF] [Request Permissions]

Letters to the editor

Cholecystectomy and bowel function
P W PLAISIER
Gut 2001; 48: 283. doi:10.1136/gut.48.2.283 [Extract] [Full text] [PDF] [Request Permissions]

MALT lymphomas and Helicobacter pylori? • Reply
S A HOPTION CANN, J P VAN NETTEN, C VAN NETTEN, M RADERER, and ANDREAS CHOTT
Gut 2001; 48: 283. doi:10.1136/gut.48.2.283a [Extract] [Full text] [PDF] [Request Permissions]

Guidelines for the management of iron deficiency anaemia • Reply
O JOLOBE and B B SCOTT
Gut 2001; 48: 283-284. doi:10.1136/gut.48.2.283b [Extract] [Full text] [PDF] [Request Permissions]

Corrections

Correction for vol. 47, p. 0
Gut 2001; 48: 284. doi:10.1136/gut.48.2.284 [Extract] [Full text] [PDF] [Request Permissions]

Cover

Plentiful Helicobacter pylori in gastric pit confirmed on Warthin Starry stain (×400). (From the case report by Bariol etal, pp 269-71.)

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	Inherited predisposition to pancreatic cancer E EFTHIMIOU, T CRNOGORAC-JURCEVIC, N R LEMOINE, and T A BRENTNALL Gut 2001; 48: 143-147. doi:10.1136/gut.48.2.143 [Extract] [Full text] [PDF] [Request Permissions]

	Is bacterial ash the flash that ignites NASH? G C FARRELL Gut 2001; 48: 148-149. doi:10.1136/gut.48.2.148 [Extract] [Full text] [PDF] [Request Permissions]

	Hepatocellular carcinoma: is surveillance cost effective? J BRUIX and J M LLOVET Gut 2001; 48: 149-150. doi:10.1136/gut.48.2.149 [Extract] [Full text] [PDF] [Request Permissions]

	Endoscopic mucosal resection for early gastric cancer S O'MAHONY Gut 2001; 48: 151-152. doi:10.1136/gut.48.2.151 [Extract] [Full text] [PDF] [Request Permissions]

	Adult liver stem cells: bone marrow, blood, or liver derived? H A CROSBY and A J STRAIN Gut 2001; 48: 153-154. doi:10.1136/gut.48.2.153 [Extract] [Full text] [PDF] [Request Permissions]

	Urgent endoscopy in lower gastrointestinal bleeding J L H WONG and H R DALTON Gut 2001; 48: 155-156. doi:10.1136/gut.48.2.155 [Extract] [Full text] [PDF] [Request Permissions]

	Helicobacter pylori augments the acid inhibitory effect of omeprazole on parietal cells and gastric H⁺/K⁺-ATPase W Beil, K-F Sewing, R Busche, and S Wagner Gut 2001; 48: 157-162. doi:10.1136/gut.48.2.157 [Abstract] [Full text] [PDF] [Request Permissions]

	Protective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: a new mechanism A Z A Leite, A M Sipahi, A O M C Damião, A M M Coelho, A T Garcez, M C C Machado, C A Buchpiguel, F P Lopasso, M L Lordello, C L O Agostinho, and A A Laudanna Gut 2001; 48: 163-167. doi:10.1136/gut.48.2.163 [Abstract] [Full text] [PDF] [Request Permissions]

	Fructose-1,6-biphosphate in rat intestinal preconditioning: involvement of nitric oxide A Sola, J Roselló-Catafau, E Gelpí, and G Hotter Gut 2001; 48: 168-175. doi:10.1136/gut.48.2.168 [Abstract] [Full text] [PDF] [Request Permissions]

	Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease R N Cunliffe, F R A J Rose, J Keyte, L Abberley, W C Chan, and Y R Mahida Gut 2001; 48: 176-185. doi:10.1136/gut.48.2.176 [Abstract] [Full text] [PDF] [Request Permissions]

	Switch from systemic steroids to budesonide in steroid dependent patients with inactive Crohn's disease A Cortot, J-F Colombel, P Rutgeerts, K Lauritsen, H Malchow, J Hämling, T Winter, A Van Gossum, T Persson, and E Pettersson Gut 2001; 48: 186-190. doi:10.1136/gut.48.2.186 [Abstract] [Full text] [PDF] [Request Permissions]

	Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease J Hampe, N J Lynch, S Daniels, S Bridger, A J S Macpherson, P Stokkers, A Forbes, J E Lennard-Jones, C G Mathew, M E Curran, and S Schreiber Gut 2001; 48: 191-197. doi:10.1136/gut.48.2.191 [Abstract] [Full text] [PDF] [Request Permissions]

	Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles M J Hopkins, R Sharp, and G T Macfarlane Gut 2001; 48: 198-205. doi:10.1136/gut.48.2.198 [Abstract] [Full text] [PDF] [Request Permissions]

	The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor $alpha$ in the pathogenesis of non-alcoholic steatohepatitis A J Wigg, I C Roberts-Thomson, R B Dymock, P J McCarthy, R H Grose, and A G Cummins Gut 2001; 48: 206-211. doi:10.1136/gut.48.2.206 [Abstract] [Full text] [PDF] [Request Permissions]

	Gastric dysrhythmias occur in gastro-oesophageal reflux disease complicated by food regurgitation but not in uncomplicated reflux A Leahy, K Besherdas, C Clayman, I Mason, and O Epstein Gut 2001; 48: 212-215. doi:10.1136/gut.48.2.212 [Abstract] [Full text] [PDF] [Request Permissions]

	Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome M J V Lewis, B Reilly, L A Houghton, and P J Whorwell Gut 2001; 48: 216-220. doi:10.1136/gut.48.2.216 [Abstract] [Full text] [PDF] [Request Permissions]

	Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure J Lysy, Y Israelit-Yatzkan, M Sestiery-Ittah, S Weksler-Zangen, D Keret, and E Goldin Gut 2001; 48: 221-224. doi:10.1136/gut.48.2.221 [Abstract] [Full text] [PDF] [Request Permissions]

	Endoscopic mucosal resection for treatment of early gastric cancer H Ono, H Kondo, T Gotoda, K Shirao, H Yamaguchi, D Saito, K Hosokawa, T Shimoda, and S Yoshida Gut 2001; 48: 225-229. doi:10.1136/gut.48.2.225 [Abstract] [Full text] [PDF] [Request Permissions]

	Antisense treatment directed against mutated Ki-ras in human colorectal adenocarcinoma H J N Andreyev, P J Ross, D Cunningham, and P A Clarke Gut 2001; 48: 230-237. doi:10.1136/gut.48.2.230 [Abstract] [Full text] [PDF] [Request Permissions]

	Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas M Anti, A Armuzzi, S Morini, E Iascone, G Pignataro, C Coco, R Lorenzetti, M Paolucci, M Covino, A Gasbarrini, FM Vecchio, and G Gasbarrini Gut 2001; 48: 238-246. doi:10.1136/gut.48.2.238 [Abstract] [Full text] [PDF] [Request Permissions]

	A new polymorphism for the RI22H mutation in hereditary pancreatitis N Howes, W Greenhalf, S Rutherford, M O'Donnell, R Mountford, I Ellis, D Whitcomb, C Imrie, B Drumm, and J P Neoptolemos Gut 2001; 48: 247-250. doi:10.1136/gut.48.2.247 [Abstract] [Full text] [PDF] [Request Permissions]

	Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis L Bolondi, S Sofia, S Siringo, S Gaiani, A Casali, G Zironi, F Piscaglia, L Gramantieri, M Zanetti, and M Sherman Gut 2001; 48: 251-259. doi:10.1136/gut.48.2.251 [Abstract] [Full text] [PDF] [Request Permissions]

	Increased risk and case fatality rate of pyogenic liver abscess in patients with liver cirrhosis: a nationwide study in Denmark I Mølle, A M Thulstrup, H Vilstrup, and H T Sørensen Gut 2001; 48: 260-263. doi:10.1136/gut.48.2.260 [Abstract] [Full text] [PDF] [Request Permissions]

	Factor V Leiden related Budd-Chiari syndrome P Deltenre, M-H Denninger, S Hillaire, M-C Guillin, N Casadevall, J Brière, S Erlinger, and D-C Valla Gut 2001; 48: 264-268. doi:10.1136/gut.48.2.264 [Abstract] [Full text] [PDF] [Request Permissions]

	Regression of gastric T cell lymphoma with eradication of Helicobacter pylori C Bariol, A Field, C R Vickers, and R Ward Gut 2001; 48: 269-271. doi:10.1136/gut.48.2.269 [Abstract] [Full text] [PDF] [Request Permissions]

	Treatment of irritable bowel syndrome: a review of randomised controlled trials R AKEHURST and E KALTENTHALER Gut 2001; 48: 272-282. doi:10.1136/gut.48.2.272 [Abstract] [Full text] [PDF] [Request Permissions]

	Cholecystectomy and bowel function P W PLAISIER Gut 2001; 48: 283. doi:10.1136/gut.48.2.283 [Extract] [Full text] [PDF] [Request Permissions]

	MALT lymphomas and Helicobacter pylori? • Reply S A HOPTION CANN, J P VAN NETTEN, C VAN NETTEN, M RADERER, and ANDREAS CHOTT Gut 2001; 48: 283. doi:10.1136/gut.48.2.283a [Extract] [Full text] [PDF] [Request Permissions]

	Guidelines for the management of iron deficiency anaemia • Reply O JOLOBE and B B SCOTT Gut 2001; 48: 283-284. doi:10.1136/gut.48.2.283b [Extract] [Full text] [PDF] [Request Permissions]

	Correction for vol. 47, p. 0 Gut 2001; 48: 284. doi:10.1136/gut.48.2.284 [Extract] [Full text] [PDF] [Request Permissions]