Special Data Supplement for this Issue

	[Clinical guidelines on the management of hepatitis C]

Leading articles

	Prion proteins and the gut: une liaison dangereuse? A N SHMAKOV and S GHOSH Gut 2001; 48: 443-447. doi:10.1136/gut.48.4.443 [Extract] [Full text] [PDF] [Request Permissions]

Commentaries

	Boning up on vitamin K J E COMPSTON Gut 2001; 48: 448-449. doi:10.1136/gut.48.4.448 [Extract] [Full text] [PDF] [Request Permissions]
	Bugs and the gut: breaking barriers to understanding P BORRIELLO Gut 2001; 48: 449. doi:10.1136/gut.48.4.449 [Extract] [Full text] [PDF] [Request Permissions]
	The changing scope of colorectal cancer C R BOLAND and T J SAVIDES Gut 2001; 48: 449-450. doi:10.1136/gut.48.4.449a [Extract] [Full text] [PDF] [Request Permissions]

Therapy update

	COX-2 inhibitors and the gastrointestinal tract I Bjarnason and K D Rainsford Gut 2001; 48: 451. doi:10.1136/gut.48.4.451 [Extract] [Full text] [PDF] [Request Permissions]

Clinical alerts

	Little benefit from mesalazine taken prophylactically after surgery for Crohn's disease P RUTGEERTS Gut 2001; 48: 452-453. doi:10.1136/gut.48.4.452 [Extract] [Full text] [PDF] [Request Permissions]

Helicobacter pylori

	Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori S Nakamura, T Matsumoto, H Suekane, M Takeshita, K Hizawa, M Kawasaki, T Yao, M Tsuneyoshi, M Iida, and M Fujishima Gut 2001; 48: 454-460. doi:10.1136/gut.48.4.454 [Abstract] [Full text] [PDF] [Request Permissions]

Inflammation and inflammatory bowel disease

	Association of the interleukin 1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians M J Carter, F S di Giovine, S Jones, J Mee, N J Camp, A J Lobo, and G W Duff Gut 2001; 48: 461-467. doi:10.1136/gut.48.4.461 [Abstract] [Full text] [PDF] [Request Permissions]
	Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease P J Roberts, K Morgan, R Miller, J O Hunter, and S J Middleton Gut 2001; 48: 468-472. doi:10.1136/gut.48.4.468 [Abstract] [Full text] [PDF] [Request Permissions]
	Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease? E J Schoon, M C A Müller, C Vermeer, L J Schurgers, R-J M Brummer, and R W Stockbrügger Gut 2001; 48: 473-477. doi:10.1136/gut.48.4.473 [Abstract] [Full text] [PDF] [Request Permissions]
	Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat S Cuzzocrea, M C McDonald, E Mazzon, H Mota-Filipe, T Centorrino, M L Terranova, A Ciccolo, D Britti, A P Caputi, and C Thiemermann Gut 2001; 48: 478-488. doi:10.1136/gut.48.4.478 [Abstract] [Full text] [PDF] [Request Permissions]
	Role of T lymphocytes in rat 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis: increased mortality after T cell depletion and no effect of T cell depletion J C Hoffmann, K Peters, S Henschke, B Herrmann, K Pfister, J Westermann, and M Zeitz Gut 2001; 48: 489-495. doi:10.1136/gut.48.4.489 [Abstract] [Full text] [PDF] [Request Permissions]

Small bowel

	Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis M T Salmela, S L F Pender, T Reunala, T MacDonald, and U Saarialho-Kere Gut 2001; 48: 496-502. doi:10.1136/gut.48.4.496 [Abstract] [Full text] [PDF] [Request Permissions]

Intestinal microflora

	Modulation of colonic barrier function by the composition of the commensal flora in the rat A García-Lafuente, M Antolín, F Guarner, E Crespo, and J-R Malagelada Gut 2001; 48: 503-507. doi:10.1136/gut.48.4.503 [Abstract] [Full text] [PDF] [Request Permissions]

Colon cancer

	Familial adenomatous polyposis: more evidence for disease diversity and genetic heterogeneity R J Scott, C Meldrum, R Crooks, A D Spigelman, J Kirk, K Tucker, D Koorey, and the Hunter Family Cancer Service Gut 2001; 48: 508-514. doi:10.1136/gut.48.4.508 [Abstract] [Full text] [PDF] [Request Permissions]
	Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families W Friedl, R Caspari, M Sengteller, S Uhlhaas, C Lamberti, M Jungck, M Kadmon, M Wolf, J Fahnenstich, J Gebert, G Möslein, E Mangold, and P Propping Gut 2001; 48: 515-521. doi:10.1136/gut.48.4.515 [Abstract] [Full text] [PDF] [Request Permissions]
	Flexible sigmoidoscopy and the changing distribution of colorectal cancer: implications for screening K McCallion, R M S Mitchell, R H Wilson, F Kee, R G P Watson, J S A Collins, and K R Gardiner Gut 2001; 48: 522-525. doi:10.1136/gut.48.4.522 [Abstract] [Full text] [PDF] [Request Permissions]
	The risk of colorectal cancer in ulcerative colitis: a meta-analysis J A Eaden, K R Abrams, and J F Mayberry Gut 2001; 48: 526-535. doi:10.1136/gut.48.4.526 [Abstract] [Full text] [PDF] [Request Permissions]

Neuroendocrine tumours

	Analysis of sporadic neuroendocrine tumours of the enteropancreatic system by comparative genomic hybridisation H Tönnies, M R Toliat, C Ramel, U F Pape, H Neitzel, W Berger, and B Wiedenmann Gut 2001; 48: 536-541. doi:10.1136/gut.48.4.536 [Abstract] [Full text] [PDF] [Request Permissions]

Pancreatic disease

	Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins S T Amann, L K Gates, C E Aston, A Pandya, and D C Whitcomb Gut 2001; 48: 542-547. doi:10.1136/gut.48.4.542 [Abstract] [Full text] [PDF] [Request Permissions]

Liver disease

	Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors R Issa, E Williams, N Trim, T Kendall, M J P Arthur, J Reichen, R C Benyon, and J P Iredale Gut 2001; 48: 548-557. doi:10.1136/gut.48.4.548 [Abstract] [Full text] [PDF] [Request Permissions]
	Enhanced glypican-3 expression differentiates the majority of hepatocellular carcinomas from benign hepatic disorders Z-W Zhu, H Friess, L Wang, M Abou-Shady, A Zimmermann, A D Lander, M Korc, J Kleeff, and M W Büchler Gut 2001; 48: 558-564. doi:10.1136/gut.48.4.558 [Abstract] [Full text] [PDF] [Request Permissions]

Gut file

	Ultrasound appearance of preclinical Oesophagostomum bifurcum induced colonic pathology P A STOREY, G FAILE, D CRAWLEY, J A VAN OOSTAYEN, S ANEMANA, P A STOREY, A M POLDERMAN, and P MAGNUSSEN Gut 2001; 48: 565-566. doi:10.1136/gut.48.4.565 [Extract] [Full text] [PDF] [Request Permissions]

Occasional viewpoint

	Search and treat strategy to eliminate Helicobacter pylori associated ulcer disease W A DE BOER and G N J TYTGAT Gut 2001; 48: 567-570. doi:10.1136/gut.48.4.567 [Extract] [Full text] [PDF] [Request Permissions]

Reviews

	Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs S G NUGENT, D KUMAR, D S RAMPTON, and D F EVANS Gut 2001; 48: 571-577. doi:10.1136/gut.48.4.571 [Abstract] [Full text] [PDF] [Request Permissions]

Letters to the editor

	Percutaneous drainage of echinococcal cysts H G SCHIPPER, P A KAGER, and J S LAMÉRIS Gut 2001; 48: 578. doi:10.1136/gut.48.4.578 [Extract] [Full text] [PDF] [Request Permissions]
	Body mass and gastro-oesophageal reflux symptoms • Reply R N MARIC, K K CHENG, J LAGERGREN, and O NYRÉN Gut 2001; 48: 578-579. doi:10.1136/gut.48.4.578a [Extract] [Full text] [PDF] [Request Permissions]
	Faecal calprotectin levels and colorectal neoplasia • Reply W G BRYDON, S S CAMPBELL, N A ANDERSON, R G WILSON, S GHOSH, and O KRONBORG Gut 2001; 48: 579-580. doi:10.1136/gut.48.4.579 [Extract] [Full text] [PDF] [Request Permissions]
	Sporadic HEV hepatitis in Italy A GRIECO, L MIELE, G GASBARRINI, and R GRILLO Gut 2001; 48: 580. doi:10.1136/gut.48.4.580 [Extract] [Full text] [PDF] [Request Permissions]
	Re-epithelialisation of Barrett's oesophagus C KELTY and R ACKROYD Gut 2001; 48: 580. doi:10.1136/gut.48.4.580a [Extract] [Full text] [PDF] [Request Permissions]
	Adenocarcinoma arising in columnar lined oesophagus following treatment with argon plasma coagulation • Reply A SHAND, H DALLAL, K PALMER, S GHOSH, M MACINTYRE, and J-L VAN LAETHEM Gut 2001; 48: 580-581. doi:10.1136/gut.48.4.580b [Extract] [Full text] [PDF] [Request Permissions]
	Outcome of lamivudine resistant hepatitis B virus infection in liver transplant recipients in Singapore C T WAI, S G LIM, and K C TAN Gut 2001; 48: 581. doi:10.1136/gut.48.4.581 [Extract] [Full text] [PDF] [Request Permissions]
	Gastric cancer in patients with benign dyspepsia K E L McCOLL, J KIDD, and D GILLEN Gut 2001; 48: 581-582. doi:10.1136/gut.48.4.581a [Extract] [Full text] [PDF] [Request Permissions]

Book reviews

	Malignant Liver Tumours. E R HOWARD Gut 2001; 48: 582. doi:10.1136/gut.48.4.582 [Extract] [Full text] [PDF] [Request Permissions]
	Self Assessment Colour Review of Gastroenterology S P L TRAVIS Gut 2001; 48: 582. doi:10.1136/gut.48.4.582a [Extract] [Full text] [PDF] [Request Permissions]
	Pancreatic Disease. M SARNER Gut 2001; 48: 582. doi:10.1136/gut.48.4.582b [Extract] [Full text] [PDF] [Request Permissions]
	Clinician's Manual on Managing Dyspepsia. R JONES Gut 2001; 48: 582. doi:10.1136/gut.48.4.582c [Extract] [Full text] [PDF] [Request Permissions]
	Clinician's Manual on Management Issues in Gastro-esophageal Reflux Disease A IRELAND Gut 2001; 48: 582. doi:10.1136/gut.48.4.582d [Extract] [Full text] [PDF] [Request Permissions]
	Recent Advances in Coloproctology. A LEATHER Gut 2001; 48: 582. doi:10.1136/gut.48.4.582e [Extract] [Full text] [PDF] [Request Permissions]

Corrections

	Correction for vol. 48, p. 425 Gut 2001; 48: 582. [Extract] [Full text] [PDF] [Request Permissions]